著者

小畑 孝四郎 井上 芳樹

出版者

近畿産科婦人科学会

雑誌

産婦人科の進歩 (ISSN:03708446)

巻号頁・発行日

vol.44, no.2, pp.143-156, 1992-03-01 (Released:2011-07-05)

参考文献数

31

被引用文献数

1

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Immunohistochemical studies were performed on type IV collagen and laminin in endometrial adenocarcinomas to relate the localization of basement membrane components to tumor invasion and metastasis. Paraffin sections were prepared from formalin-fixed specimens of 58 endometrial carcinomas. Immunohistochemical staining was performed with primary mouse anti-human type IV collagen antibody or rabbit anti-human laminin antibody and by the ABC method. DNA ploidy analysis was added in 29 cases. Staing for type IV collagen was found in 37.1 ± 19.6% of well differenciated adenocarcinomas, 28.7±16.1% of moderately differenciated lesions, and 18.6±7.8% of poorly differenciated lesions. The respective percentages for laminin were 36.3±17.4%, 28.9±18.6%, and 22.8±17.1%. In metastatic lymph node, positive staining was similar to that in primary leisions. DNA aneuploid lesions showed less staining for laminin. Tumor cells had cytoplasmic laminin in 7 cases and it was rarely seen in the basement membrane. Six of those tumors were G2 or G3 and six had DNA aneuploid. Five of those patients died of primary disease and four of intraperitoneal recurrence.The features of the basement membrane in tumors may reflect construction rather than destruction by cancer cells.

著者

小泉 直子 井上 芳樹 塚本 利之

出版者

The Japanese Society for Hygiene

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.38, no.3, pp.667-676, 1983-08-30 (Released:2009-02-17)

参考文献数

11

被引用文献数

1

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Diurnal variations were recorded of 10 substances from the urine of 22 healthy women, ranging from 32 to 65 years of age. Twenty-four-hour urine collections were done at each micturition and blood samples were taken on the same day.From the data, it was examined whether the use of creatinine ratio as a measure of the completeness of a 24-hour urine samples was reliable.The results were as follows:1. Maximum/minimum concentration ratios of various urinary substances were 1.2-4.6, 1.9-9.0, 1.3-11, 1.3-8.0, 1.6-12, 1.5-12, 1.7-11, 1.8-9.8, and 2.0-12, for (specific gravity-1) ×1, 000, creatinine, urea nitrogen, uric acid, calcium, inorganic phosphorus, cadmium, zinc, and copper, respectively. There were very large individual variations-2.6-78-for the ratios of urinary β2-microglobulin.2. Blood urea nitrogen slightly increased with age, but other substances showed no such changes.3. The mean values of each substances matched between those taken at individual micturitions and those taken over 24 hours.4. Concentrations of substances in early morning urine did not always show the high levels compared with those of a 24-hour urine.5. Creatinine concentrations decreased with age. For elderly women, this fact resulted the high values from correction by creatinine for the concentrations of urinary substances.6. Wide diurnal variations for values corrected by specific gravity or creatinine were observed of urinary 10 substances, and such substances were inaffective in correcting urinary concentrations.7. The mean specific gravity of a 24-hour urine of all subjects was 1.018. For elderly women, the value calculated by specific gravity, that is, the one multiplied by 18/(G-1)×1, 000, was more accurate than the creatinine ratio.8. Urinary protein or glucose had almost no influence on specific gravity, except in the case of glucose concentrations over 500mg/dl.

著者

原田 直哉 中島 容子 中村 徹 橋本 平嗣 林 道治 堀江 清繁 赤崎 正佳 小林 浩 井上 芳樹 高井 一郎 潮田 悦男 大井 豪一 小畑 孝四郎 喜多 恒和 下里 直行

出版者

近畿産科婦人科学会

雑誌

産婦人科の進歩 (ISSN:03708446)

巻号頁・発行日

vol.65, no.1, pp.1-10, 2013

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妊婦健康診査(以下,健診)をほとんど受診することなく分娩に至る妊婦健診未受診妊婦(以下,未受診妊婦)に関する既報では多くが施設単位であるため,奈良県全体での実態を把握するためのアンケート調査を実施した.未受診妊婦の定義は,(1)全妊娠経過を通じての産婦人科受診回数が3回以下,または(2)最終受診日から3カ月以上の受診がない妊婦,のいずれかに該当する場合とした.県内のすべての分娩施設に対し,平成22年1月からの1年間の分娩数と,未受診妊婦があれば個別に母児の状況を調査した.年間11,168例の総分娩数中の11例(0.10%)の未受診妊婦を認めた.初産婦は4例(36.4%)で,5回あるいは7回と多産の経産婦もいた.未入籍は9例(81.8%),妊娠のパートナーと音信不通になっている者が5例(45.6%)いた.重篤な合併症を認めた母体が3例(27.3%),集中治療室に収容された新生児が3例(27.3%)であった.産褥健診を受診しなかった1例(9.1%)は,新生児の1カ月健診も受診しなかった.未受診を防ぐことは,母児の健康を確保するだけでなく,周産期母子医療センターへの患者集中を防ぎ,周産期の医療資源の有効利用にもつながるため,社会全体でその解消に取り組む必要がある.また未受診であった妊婦に対しては,虐待のハイリスクグループと考え,その後を通常の妊婦と異なる個別の対応を行うことにより,虐待を防止することができるかもしれない.〔産婦の進歩65(1):1-10,2013(平成25年2月)〕