著者

石崎 達 宮本 昭正 清水 保 可部 順三郎 牧野 荘平 児玉 太郎 信太 隆夫

出版者

The Japanese Respiratory Society

雑誌

日本胸部疾患学会雑誌 (ISSN:03011542)

巻号頁・発行日

vol.2, no.3-4, pp.217-229, 1964-12-20 (Released:2010-02-23)

参考文献数

28

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To investigate air pollution respiratory diseases (especially T-Y asthma) among Japanese, mass survery in the Niigata area and T-Y area was carried out. Subjects submitted for statistic analysis were 2825 in total. There were increased incidence of respiratory symptoms such as chronic coughing, increased sputum production and throat irritation among the subjects who are living in T-Y area. This incidence was highest in the native group of T-Y area and particulary high among smokers and subjects with allergic constitution. There were no increased incidence of air way obstructive diseases in T-Y area but group of subjects who were exposed to heavy air pollution tended to have low vital capacity. These reaults give the evidence that air pollution is harmful for respiratory tract.There were no definite evidence that respiratory sensitivity to inhaled acetylcholine in subjects in T-Y area was increased, inspite of the fact that asthmatic patients have significantly high sensitivity to acetylcholine. On the other hand, 7 cases of T-Y asthma at Zama U. S. Army Hospital showed the range of bronchial asthma and chronic bronchitis.Among 237 cases of asthmatic patients at our clinic there were only 15 cases who deveolped their 1st onset of asthma in T-Y area after their move to this industrialized area from rural areas but none of them presented compatible characteristics with the entity of the so-called T-Y asthma, though some presented quite similar pictures. From our study, it may not be quite feasible to use the name of T-Y asthma for Japanese since the incidence of air way obstructive diseases does not seem to have particularly increased in T-Y area. Possible reasons for the differnce between our views and those of the U. S. military physicians were discussed.

著者

宮本 昭正 可部 順三郎 荒木 英斉 牧野 荘平 児玉 太郎

出版者

The Japanese Respiratory Society

雑誌

日本胸部疾患学会雑誌 (ISSN:03011542)

巻号頁・発行日

vol.4, no.3-4, pp.171-179, 1966-12-31 (Released:2010-02-23)

参考文献数

9

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Thirty eight asthmatic patients were studied on pulmonary diffusing capicity for carbon monoxide, history of bronchial asthma, chest X-ray and some of pulmonary function tests. Moreover, pulmonary diffusing capacity among normal subjects was measured and compared to that of asthmatic patients. DLCO was measured by Forster's single breath method modified by Oglivie and CO-workers. Krough's “Permiability” (KCO) was calculated from the same procedure as DLCO.1) Pulmonary diffusing capacity was found to decrease with advancing age and to increase with increasing either height or alveolar volume. Pulmonary diffusing capacity of asthmatic patients was almost equal to or higher than that of nomal subjects.2) No significant correlation was found between pulmonary diffusing capacity and FEV 1.0/FVC.3) Pulmonary diffusing capacity, especially KCO, showed an tendency to decrease with increasing severity of asthma and with advancing emphysematous change in chest X-ray.4) Asthmatic patients were divided into 2 groups; patients who had asthmatic symptoms since childhood, and patients who had the first experience of asthmatic attacks after adolescence. There was found no significant difference between pulmonary diffusing capacity of these 2 groups. From this result, an impression is given that long-standing bronchial asthma does not necessarily progress to diffuse obstructive emphysema.5) The more the patients showed severe asthmatic symptoms, the more marked emphysematous changes were proved in chest X-ray of the majority.6) Pulmonary diffusing capacity was measured among asthmatic patients with history similar to “Tokyo-Yokohama asthma”. No cases showed lowered pulmonary diffusing capacity. This result suggests that there is neither destructive changes as seen in the lung of chronic emphysema nor alveo-capillary block among these patients.