著者

荒木 英斉

出版者

一般社団法人 日本アレルギー学会

雑誌

アレルギー (ISSN:00214884)

巻号頁・発行日

vol.10, no.6, pp.354-370,381, 1961-06-30 (Released:2016-10-20)

被引用文献数

4

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Incidence of sensitization with several air-borne pollens was studied in the Japanese mainly by direct intradermal test, and in some cases Prausnitz-Kustner test, eye test, and provocation by pollen inhalation were studied also. Individuals tested were 265 patients with bronchial asthma, 70 patients with nasal allergy and 602 control persons. Pollens used were short ragweed (Ambrosia artemisiifolia var. elatior), Japanese red pine(Pinus densiflora), Japanese black pine (Pinus Thumbergi), Japanese cedar (Cryptomeria japonica), and Japanese hop (Humulus japonicus). For the comparative study, house dust was also used. In direct skin testing, 0.05 ml of allergen extracts of 1:1000 dilution was injected intracutaneously. In asthmatic patients, each of the distribution curves of diameters of erythema and wheal caused by the intradermal injection with house dust extract showed two peaks with a minimum between them, and the minimum point situated at 15〜20 mm in erythema and 9 mm in wheal. Similar figures were obtained in normal control persons. With short ragweed pollen, it was the same. The first peak, which was estimated to correspond to unspecific reactions, was lower than that of normal control persons, while the second peak which was considered to correspond to specific reactions was higher in asthmatic patients. Only few normal persons and fairly numerous asthmatic patients showed the erythema reactions above 41 mm in diameter. The correlation between erythema and wheal was high (r=0.80 in house dust. r=0.78 in ragweed pollen). From these results. the author proposed the following criteria of intradermal skin test with inhalant allergens; negative (-): erythema less than 10 mm in diameter doubtful (±): erythema 11-20 mm slightly positive (+): erythema 21-40 mm, wheal less than 9 mm moderately positive (〓): erythema 21-40 mm, wheal 10-14 mm strongly positive (〓): erythema above 41 mm, or wheal above 15 mm, or with marked pseudopods After these standards, positive skin reactions to short ragweed pollen were observed in 36% of asthmatic patients, 32% of patients with nasal allergy including bacterial allergy, 52% of patients with nasal allergy except bacterial allergy, and 19% of normal control persons, whereas positive skin reactions to house dust in these four groups were 69%, 51%, 65%, and 23% respectively. But positive skin reactions to Japanese red pine and Japanese cedar pollens were observed far less frequently than that to ragweed pollen, and only very few cases reacted to Japanese black pine and Japanese hop pollens. PK-test was successful in 7 of 11 cases who showed positive intradermal reaction to short ragweed pollen, and in 2 of 3 cases who showed positive intradermal reaction to Japanese red pine pollen. Eye test was carried out with the extracts of pollens, and provocative test by inhalation was done with pollen itself. Both of these test showed positive reactions in rather few cases. Cross reaction between house dust and short ragweed pollen were proved by PK-reaction. House dust might have more allergenic components than short ragweed pollen as judged by skin test. A Japanese patient, who never been abroad but suffering from allergic rhinitis and laryngitis evidently caused by short ragweed pollen, was described in details. Some possible explanations concerning the discrepancy between the results of skin test and the incidence of pollinosis were discussed.

著者

宮本 昭正 可部 順三郎 荒木 英斉 牧野 荘平 児玉 太郎

出版者

The Japanese Respiratory Society

雑誌

日本胸部疾患学会雑誌 (ISSN:03011542)

巻号頁・発行日

vol.4, no.3-4, pp.171-179, 1966-12-31 (Released:2010-02-23)

参考文献数

9

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Thirty eight asthmatic patients were studied on pulmonary diffusing capicity for carbon monoxide, history of bronchial asthma, chest X-ray and some of pulmonary function tests. Moreover, pulmonary diffusing capacity among normal subjects was measured and compared to that of asthmatic patients. DLCO was measured by Forster's single breath method modified by Oglivie and CO-workers. Krough's “Permiability” (KCO) was calculated from the same procedure as DLCO.1) Pulmonary diffusing capacity was found to decrease with advancing age and to increase with increasing either height or alveolar volume. Pulmonary diffusing capacity of asthmatic patients was almost equal to or higher than that of nomal subjects.2) No significant correlation was found between pulmonary diffusing capacity and FEV 1.0/FVC.3) Pulmonary diffusing capacity, especially KCO, showed an tendency to decrease with increasing severity of asthma and with advancing emphysematous change in chest X-ray.4) Asthmatic patients were divided into 2 groups; patients who had asthmatic symptoms since childhood, and patients who had the first experience of asthmatic attacks after adolescence. There was found no significant difference between pulmonary diffusing capacity of these 2 groups. From this result, an impression is given that long-standing bronchial asthma does not necessarily progress to diffuse obstructive emphysema.5) The more the patients showed severe asthmatic symptoms, the more marked emphysematous changes were proved in chest X-ray of the majority.6) Pulmonary diffusing capacity was measured among asthmatic patients with history similar to “Tokyo-Yokohama asthma”. No cases showed lowered pulmonary diffusing capacity. This result suggests that there is neither destructive changes as seen in the lung of chronic emphysema nor alveo-capillary block among these patients.

著者

石崎 達 牧野 荘平 荒木 英斉 根本 順吉

出版者

一般社団法人 日本アレルギー学会

雑誌

アレルギー (ISSN:00214884)

巻号頁・発行日

vol.23, no.11, pp.753-759,778, 1974

被引用文献数

4

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気管支喘息者に与えて記録させた喘息日記を集計して, 満3年間にわたり毎日の喘息発作出現率をもとめ, この出現率の日変動, 気象要因との相関関係を追跡した.気象要因は気象庁のデータからえた.統計処理の基準には移動15日平均値からの偏差をもとめ, 1SD 以上の差を増加または減少と規定した.気象要因曲線と喘息発作曲線の一致度(上昇, 平, 下降)から, 高気圧下で喘息発作数の増加傾向がみとめられた.喘息発作に関連する天候要因としては晴, 曇, 天候不定(前線通過), 雨と分類するのが重要で, 後2者の場合発作が多発する.その理由を追跡したところ, 寒冷刺激とくにその変化(前日との湿度低下)が重要で, 湿度は補助要因と思われた.これは年間の発作多発月が9月であることと一致する現象である.痰は湿度が高く天候不定, 雨の日, および乾燥日(湿度40%以下)に多発しやすいことがわかった.