著者

森山 祐輔 有森 和彦 中野 眞汎

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.18, no.3, pp.245-251, 1992-06-20 (Released:2011-08-11)

参考文献数

11

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The statistics indicates that the constitution of children, which includes height and body weight, has developed during the last 40 years.Therefore, we investigated that body surface area of children at present for every age which was calculated with Fujimoto's formula was greater than that in 1948.So we reexamined pediatric dose obtained from Augsberger's I, Augsberger's II, Young's, and Fujimoto's formula.The pediatric dose ratio based on body surface area in 1948 much more corresponded with the dose ratio obtained from the Augsberger's II formula.On the other hand, the pediatric dose ratio based on body surface area for every age in 1987 was shifted to higher dose ratio compared with that obtained from the Augsberger's II formula. The pediatric dose ratios obtained from three formulas except Fujimoto's formula indicated lower dose ratio than that obtained from Fujimoto's formula.Furthermore, under the age of five, pediatric dose ratio calculated from Fujimoto's formula was higher than that calculated from Du Bois's formula.The difference between the two dose ratios was larger as the age of children was lower.Consequently, considering big change in the constitution of children during the last 40 years, there may be a possibility to estimate lower pediatric dose than the dose which was required in the present children, if the pediatric dose was eviluated with Augsberger's II formula.

著者

有森 和彦 宮崎 万理 若山 香都美 弟子丸 恵実 中野 眞汎

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.16, no.6, pp.380-384, 1990-12-20 (Released:2011-08-11)

参考文献数

13

著者

永田 将司 岩切 智美 奥村 学 有森 和彦

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.37, no.5, pp.289-295, 2011 (Released:2012-08-02)

参考文献数

5

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Pharmacists can play a significant role in medical care by helping to ensure the proper use of drugs, and a knowledge of pharmacokinetics is indispensable for this. Therapeutic Drug Monitoring (TDM) is a pharmacy practice that involves the full use of such knowledge. Practical training in TDM in pharmacist education should thus be an optimal way acquiring skill in applying pharmacokinetics knowledge in the clinical setting. However, in the Model Core Curriculum for practical training at hospitals implemented in 2010, there is only 1 specific behavioral objective (SBO) concerning TDM, and only 1 day is given to training on TDM. With this in mind, we developed an original experience-based TDM curriculum that includes 5-days of practical training. The curriculum was introduced for students in the 2010 pharmaceutical internship to evaluate its components.All students who took our curriculum considered that the 1-day of TDM training stipulated in the Model Core Curriculum was not sufficient, and that around 5 days of training, the period we have set, would be necessary. They also indicated a high level of satisfaction with it, viewing the training components as appropriate. These findings suggest that our curriculum would be effective.

著者

有森 和彦 河野 ひとみ 近見 和代 岩奥 玲子 中野 眞汎

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.13, no.6, pp.361-365, 1987-12-20 (Released:2011-08-11)

参考文献数

4

被引用文献数

3 1

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Serum concentrations of phenytoin and phenobarbital which were administered as the tablet or the powder in epileptic patients were determined by the fluorescence polarization immunoassay method. The serum concentrations of phenytoin administered as the tablet (Hydantol®) were higher than those as the powder (Aleviatin ® fine granules). To investigate the differences in serum levels following administration of each preparation, compliance, dissolution characteristics of the preparations and losses of the powder after operating the dividing and packing machines were investigated. Since phenytoin dissolved from the Hydantol ® tablet more slowly than from the Aleviatin ® fine granules, the differences in dissolution rates of both preparations do not seem to be the cause of higher serum concentrations in patients taking the Hydantol ® tablet.The amount of the powder after operating three types of dividing and packing machines was decreased about 2-8% of the original amount of the powder by adhesion to various dividing sites of the machine. Accordingly, the lower serum concentrations of phenytoin after the administration of the powder may be due to losses of the powder by the adhesion to dividing and packing machine and due to non-compliance.Although there was no significant difference in the serum concentrations of phenobarbital between the tablet (Phenobal ®) and the powder (JP X phenobarbital powder), large variations in the serum concentrations were observed following administration of the powder. In view of the result of questionnaire and bitterness of the drug, a possibility of non-compliance of the powder was considered. Thus, it may be suggested that these factors should be concerned invariations of the serum concentrations.

著者

荻窪 哲也 日高 宗明 奥村 学 藤田 健一 山崎 啓之 浅生 将英 岩切 智美 佐々木 裕美 児玉 裕文 有森 和彦

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.32, no.5, pp.392-399, 2006-05-10

被引用文献数

2 2

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In view of the lack of information on the extent to which tea beverages inhibit the activity of human cytochrome P 450 3A (CYP 3A), we investigated their effect on the midazolam 1' -hydroxylation activity of CYP 3A contained in human liver microsomes. "Grapefruit (white)" was used as a positive control, and "Valencia Orange", as a negative control. All the tea beverages tested significantly inhibited the midazolam 1' -hydroxylation activity of CYP 3A in a concentration-dependent manner and inhibition was particularly marked for Katekin 600^[○!R] and Banso-reicha^[○!R] (5.0%, v/v). The potency of the inhibitory effects was similar to that of grapefruit. The inhibitory effects on the activity of CYP 3A were enhanced by preincubation of tea samples (2.5%, v/v) with microsomal fractions for 5 to 30min in a preincubation period-dependent manner. These results suggest that Katekin 600^[○!R] and Banso-reicha^[○!R] contain mechanism-based inhibiting agents. Further, the inhibitory effects on CYP 3A of green tea beverages seemed to be enhanced by catechins with the enhancement depending on the catechin concentration indicated on the label. In conclusion, we found that there were ingredients that inhibited CYP 3A activity in all of the tea beverages, and they were probably catechins.