文献一覧: 前原隆 (著者)

3 0 0 0 OA シェーグレン症候群患者に対する唾液分泌促進薬の有効性と副作用の検討~セビメリン塩酸塩とピロカルピンと塩酸塩の比較~

著者: 篠崎昌一森山雅文林田淳之介田中昭彦前原隆古川祥子太田美穂今林佑美中村誠司
出版者: 社団法人日本口腔外科学会
雑誌: 日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日: vol.61, no.3, pp.147-153, 2015-03-20 (Released:2015-09-29)
参考文献数: 13
被引用文献数: 1

Objectives: Cevimeline hydrochloride (CH) and pilocarpine hydrochloride (PH) are recognized as salivation-inducers with a high affinity for M3 muscarinic receptors. However, these drugs have a high frequency of side effects, including digestive symptoms and hyperhidrosis. We compared the effectiveness and side effects of these two drugs before and after a medication change.Materials and Methods: Seventy-six patients with Sjögren's syndrome were divided into the following four groups: 1) CH group, CH was administered for 12 months; 2) PH group, PH was administered for 12 months; 3) CH-PH group, CH was administered for 6 months followed by PH for 6 months; 4) PH-CH group, PH was administered for 6 months followed by CH for 6 months. We measured the salivary flow rate and recorded the subjective symptoms in each group.Results: In each group, stimulated whole saliva (SWS) and unstimulated whole saliva (UWS) significantly increased after 3 months and 6 months, respectively, and subjective symptoms improved after 3 months. The incremental changes in both SWS and UWS did not differ significantly between the groups. The CH and PH groups both had digestive symptoms (32.3% and 32.1%, respectively) and hyperhidrosis (29.0% and 39.3%, respectively). We found no significant difference in salivary flow rate or subjective symptoms after the medication change. However, the frequencies of side effects in the CH-PH and PH-CH groups decreased significantly for both digestive symptoms (9.7% and 10.7%, respectively) and hyperhidrosis (25.8% and 14.3%, respectively).Conclusions: After changing the salivation-inducing drug, there was no significant difference in salivary function or subjective symptoms, while the frequency of side effects markedly decreased. These results suggest that changing the salivation-inducing drug effectively reduces side effects.

2018-10-28 18:27:57
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1 0 0 0 IgG4関連疾患の免疫学的特異性を基盤とした病因解明と疾患モデルマウスによる検証

著者: 中村誠司前原隆新納宏昭森山雅文柴田琢磨安河内友世坪井洋人
出版者: 九州大学
雑誌: 基盤研究(A)
巻号頁・発行日: 2020-04-01

本研究では、代表的罹患臓器である唾液腺を解析し、特異なT細胞、B細胞、マクロファージ(Mφ)のサブセットが病態形成に関わっていることを明らかにした。しかし、詳細な病態形成の分子機構や病因は判っていない。そこで、本研究では、従前の研究成果を基盤とし、IgG4-RDの病因を解明し、新規治療法開発の基盤を築くことを目指す。第1にサブセット間の相互作用を解析して病態形成機序を明確にし、第2に発症に関わるT細胞とその認識抗原を同定し、第3に特異なMφを遺伝子導入により誘導したマウスを同定した抗原などで刺激することにより病態を再現する疾患モデルマウスを完成させる。