著者
清水 潤 前田 明子
出版者
日本神経治療学会
雑誌
神経治療学 (ISSN:09168443)
巻号頁・発行日
vol.37, no.2, pp.141-145, 2020 (Released:2020-08-31)
参考文献数
9

The idiopathic inflammatory myopathies (IIMs) are a group of heterogenous conditions showing immune–mediated muscle damage. Increasing numbers of myositis–specific autoantibodies (MSAs) or myositis–associated autoantibodies (MAAs) have been shown to be associated with a majority of patients with IIMs year after year. It has been known that there are associations between these autoantibodies, especially MSAs, and characteristic clinical features. Anti–mitochondrial antibody (AMA) is a characteristic marker of primary biliary cirrhosis. We previously studied clinical features of IIMs associated with AMA and reported. In the report, we found that IIMs associated with AMA frequently include patients with a clinically chronic disease course, muscle atrophy, cardiopulmonary involvement and granulomatous inflammation. After we reported, several case repots mainly in Japanese literature and four case series in English literature have been reported on clinicopathological features of IIMs associated with AMA. Of the four case series, one is negative, one is partly supportive, and two are supportive to our findings. In this review, we summarized the findings of four case series in English literature in comparison with our previous report. We also discussed the reasons of the differences in findings among reports. Considering growing numbers of literature supporting association between AMAs and characteristic clinical features ; chronic disease course, muscle atrophy, and cardiac involvement, we believe AMA should be added to the growing list of myositis–associated antibodies.
著者
小海宏之 前田明子 山本愛 加藤佑佳 岡村香織 園田薫 安藤悦子 岸川雄介
出版者
花園大学
雑誌
花園大学社会福祉学部研究紀要 (ISSN:09192042)
巻号頁・発行日
vol.18, pp.91-96, 2010-03

本研究は、小海ら(2000 ,2004,2008)による日本語版 Mini-Mental State Examination(MMSE)の検出力と特異性を明らかにした。この MMSEの cut-off値を 24/25点とした場合、感度 0.837、特異度 0.957となり、臨床群( amnestic Mild Cognitive Impairment; MCIと probable Alzheimer's Disease; ADを含む)と健常群を判別するためのスクリーニングテストとして、十分な検出力と特異性を有することが示唆された。しかし、同様に 26/27点を cut-off値とした場合、感度 0.889、特異度 0.739となり、amnestic MCI群と健常群を判別するためのスクリーニングテストとして、十分な検出力と特異性を有するとは言い難く、他の認知機能検査による精査を行う必要性があることが示唆された。