著者

岩田 英治 古土井 春吾 鰐渕 聡 岸本 恵実 明石 昌也 古森 孝英

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.64, no.2, pp.83-87, 2018-02-20 (Released:2018-04-20)

参考文献数

17

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Osteonecrosis of the jaw is one of the problematic side effects observed during administration of angiogenesis inhibitors in patients receiving treatment for cancer. We report a case of osteonecrosis of the jaw in a patient receiving sunitinib. The patient was a 72-year-old man who was referred to our hospital because of exposed bone and contact pain of the tongue. After the clinical diagnosis of osteonecrosis of the jaw, observation and irrigation of the exposed bone were frequently performed. Four months later, the lesion healed. After 1 year, exposed bone was found in other sites ; however, it disappeared a month later. The present case suggests that the use of sunitinib can be associated with osteonecrosis of the jaw and indicates that invasive dental treatment and the status of the main disease should be considered when prescribing sunitinib, as is done when prescribing bisphosphonates or denosumab.

著者

深川 智恵 古土井 春吾 高橋 英哲 山田 周子 渋谷 恭之 古森 孝英

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.56, no.10, pp.605-608, 2010-10-20 (Released:2013-10-31)

参考文献数

9

被引用文献数

1

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Lemierre syndrome is a potentially life-threatening disease caused by an acute oropharyngeal infection with secondary septic thrombophlebitis of the internal jugular vein, frequently associated with abscess formation in distant organs.We report the case of a 78-year-old woman who received surgical therapy, chemotherapy, and radiation therapy for malignant lymphoma in 2001. She visited our hospital because of a swelling and pain of the left submandibular region in August 2009. The patient was immediately hospitalized to control the pain and infection. PET images showed tracer uptake in the lung. Bilateral multiple septic emboli of the thorax were detected on CT. On the basis of these findings, Lemierre syndrome was diagnosed. The patient was treated with antibiotics intravenously, and surgical drainage was performed. All symptoms improved, and she was discharged after 32 days.

著者

吉位 尚 濱本 嘉彦 村岡 重忠 糀谷 淳 古土井 春吾 麻柄 真也 大塚 芳基 中尾 薫 寺延 治 島田 桂吉 古森 孝英

出版者

特定非営利活動法人 日本口腔科学会

雑誌

日本口腔科学会雑誌 (ISSN:00290297)

巻号頁・発行日

vol.48, no.6, pp.479-488, 1999-11-10 (Released:2011-09-07)

参考文献数

47

被引用文献数

5

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The clinical efficacy of long-term roxithromycin (RXM) treatment was examined objectively in 8 patients with chronic diffuse sclerosing mandibular osteomyelitis. RXM was administered orally at a dose of 300mg per day for 68 days to 66 months.As a result, the results of 7 out of 8 cases (87.5%) were assessed effective, and the symptoms had disappeared in 1 to 12 months. One case assessed poor had several operations and various kinds of antibiotic therapy for more than 11 years before this therapy. In 7 cases assessed effective, the improvement of osteolytic changes on X-ray was observed. However, most of the X-ray findings remained osteosclerosis or the osteosclerosis became more predominant, when this therapy was terminated. It was considered that X-ray findings would take a long time to be normalized. Therefore, the optimum duration of administration which is the time to terminate this therapy should be decided according to the improvement of symptoms along with the disappearance of osteolytic findings on X-ray. Diarrhea and stomach discomfort in 1 case, and liver dysfunction in 1 case were found, however, these side effects were slight.The mechanisms of RXM are unclear however, these results indicate that long-term RXM treatment has therapeutic possibilities for diffuse sclerosing mandibular osteomyelitis and should be used as the first choice followed by surgical treatment if necessary.

著者

山崎 隆廣 吉位 尚 黒木 栄司 宮井 大介 林 徹 西村 栄高 吉川 朋宏 吉岡 歩 古土井 春吾 竹野々 巌 市来 浩司 大塚 芳基 中尾 薫 古森 孝英

出版者

一般社団法人 日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.18, no.2, pp.54-58, 1999-08-01 (Released:2010-06-08)

参考文献数

24

被引用文献数

2

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Cases with postoperative infections following teeth extraction are experienced occasionally, however, there have been few reports about the problems following teeth extraction. The purpose of this study was to investigate the influence of general and local background of cases with infections following teeth extraction. The results were as follows:1) The infections following teeth extraction occurred in 11 (2.1%) out of 517 cases.2) There was no relationship between age or underlying disease and the postoperative infection rate.3) The incidence of the infection was the highest after mandibular third molar surgery, however, the relationship between the surgical procedure such as incision or removal of the bone and the infection rate was not found.4) The infection rate of cases with acute inflammation before surgery was higher than that of the cases without any inflammatory signs.5) Prophylactic antibiotic administration was performed on 282 (54.5%) out of 517 cases. The incidence of the infections of the cases with prophylaxis was almost the same as the cases without prophylaxis.6) The postoperative pain in infection cases tends to last longer than the normal course. Therefore, it is important to observe carefully the course of pain to make a diagnosis of postoperative infection.

著者

古土井 春吾 吉位 尚 濱本 嘉彦 村岡 重忠 糀谷 淳 寺延 治 古森 孝英

雑誌

日本口腔診断学会雑誌 = Japanese journal of oral diagnosis/oral medicine (ISSN:09149694)

巻号頁・発行日

vol.13, no.1, pp.1-5, 2000-04-20

被引用文献数

1