著者

岡井 恒 古江 秀昌 吉村 恵

出版者

日本疼痛学会

雑誌

PAIN RESEARCH (ISSN:09158588)

巻号頁・発行日

vol.23, no.1, pp.11-18, 2008-02-20 (Released:2013-07-04)

参考文献数

16

被引用文献数

6 4

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Neurotropin®, a non protein extract from inflamed rabbit skin inoculated with vaccinia virus, is well known as an analgesic for chronic pain such as low back pain and postherpetic neuralgia, etc. In previous behavioral studies, we have shown that neurotropin activates the monoaminergic descending pain inhibitory system. In the present study, we examined the effects of neurotropin on serotonergic neurons in the nucleus raphe magnus (NRM, the origin of serotonergic descending pain inhibitory neuron) in the rostroventromedial medulla using whole-cell patch-clamp technique in brainstem slices. In some instances, recorded neurons were identified as NRM neurons with neurobiotin filled in the recording pipettes. NRM neurons had a resting membrane potential of about -60 mV. Bath application of neurotropin (1.0 NU/mL) depolarized NRM neurons, and it resulted in initiating an action potential under current-clamp conditions. Under voltage-clamp conditions at a holding potential of -70 mV, NRM neurons exhibited spontaneous excitatory postsynaptic currents (EPSCs). Neurotropin (0.2 - 1.0 NU/mL) did not change the frequency and amplitude of spontaneous EPSCs. However, neurotropin dose-dependently induced an inward current in approximately 60% of NRM neurons tested. The neurotropin-induced inward current was observed even in the presence of tetrodotoxin (1 µM). The reversal potential for the current was close to 0 mV, indicating that the neurotropin-induced current is mediated by the activation of non-selective cation channels. Neurotropin produced an inward current, in all neurons immunohistochemically stained for tryptophan hydroxylase (TPH), a marker for serotonergic neuron. These results indicate that neurotropin directly excites serotonergic NRM neurons without affecting the excitatory synaptic inputs to NRM neurons. This facilitatory action of neurotropin on serotonergic NRM neurons may have an important role for the neurotropin-induced analgesia.

著者

尾崎大輔 広野彩子 吉村恵美

雑誌

日本経済学会2020年度秋季大会

巻号頁・発行日

2020-07-21

著者

室崎 生子 小伊藤 亜希子 中島 明子 上野 勝代 吉村 恵 松尾 光洋

出版者

平安女学院大学

雑誌

基盤研究(C)

巻号頁・発行日

2002

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建築・都市計画分野における女性の専門職比率、昇格実態などを把握するために、14年度に都道府県を対象に、15年度には、東京23区を対象に、アンケート調査を実施し、社会進出状況と昇格における男女差の実態を把握した。建築・都市計画分野における女性の専門職の採用は近年、増加の傾向にあることは把握できたが、建築・都市計画分野における女子学生の増加率に比べれば、その増加を反映したものとはなっていないといえる。また、昇格に対しては男女差別が存在しており、等しく昇格試験が受けられる自治体と不明瞭なところとがある。大学における教員比率についても、女子学生の増加に対応したものとなっていないこともわかっており、採用や昇格における改善はエンパワメント政策上の課題であることが確認できた。また、国外比較事例として、1年度は韓国、2年度はイギリス、フィンランドを対象とし、ジェンダーエンパワメントの実態を調査した。いずれの国でも建築・都市計画分野において女性が増加してきており、先進的に活躍する女性たちが存在することが感じられたが、いずれの国においてもジェンダーによる影響が皆無ということはなく、引き続き国際的にも課題であることも確認できた。女性政策や社会の発展からすると後発とも言える韓国は、民主化政策の中で急速に女性政策が進展した国である。韓国調査からは、有効な政策を打つことで、エンパワメントがはかれることが示唆された。ジェンダーエンパワメントが高いフィンランドでは、福祉制度や女性政策が進んでおり、働く環境がととのっていることが、初期から中期のポストでの差がない状態を生んでいることが理解できた。また、養成課程での女性比率が社会進出に反映するなどエンパワメントの実態を目の当たりにすることができた。イギリスにおいては、女子学生の増加に見合った女性建築職の進出の場や活躍の場が少ないなど日本の状況とにており、社会的に活躍できにくい状況の解明調査に取り組んでいるところであった。民間企業に勤める建築専門職の実態調査等が、今後の課題としてのこった。労働政策、福祉政策、女性政策等の連携なしに建築専門職分野のエンパワメントもありえず、総合的視野からの改善ときめ細かなところからの支援改善を連携する提言をしていくことが課題である。

著者

小宮山 櫻子 中原 はるか 津田 幸子 吉村 恵理子 室伏 利久

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.72, no.6, pp.493-500, 2013

被引用文献数

2

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The purposes of this study was to elucidate the clinical characteristics of patients suffering from migraine-associated vertigo (MAV) including results of cervical vestibular evoked myogenic potential (cVEMP) and ocular VEMP (oVEMP). Thirty patients diagnosed as having MAV based on the diagnostic criteria by Sakata et al. were enrolled. We performed a retrospective chart review. These patients underwent medical history taking and examinations including cVEMP, oVEMP and a caloric test. All examinations were performed during a symptom-free interval. Twenty one patients (70%) experienced rotatory vertigo, 5 patients (17%) had floating dizziness and 4 patients (13%) had both. Twenty six patients (87%) reported tinnitus and/or aural fullness unilaterally or bilaterally. Their vertigo or dizziness lasted under 60 minutes in 10 patients (34%), 1 hour to 24 hours in 14 patients (46%), and over one day in 5 patients (17%). Canal paresis in the caloric test was observed in 5 patients (17%). Concerning cVEMP, 4 of the 30 patients (13%) showed absent cVEMPs bilaterally, 2 patients (7%) showed absent cVEMPs reflexes unilaterally, and one (3%) demonstrated decreased cVEMP amplitudes unilaterally. Only one patient showed prolonged cVEMP latencies. Concerning oVEMP, 6 of the 30 patients (20%) had absent oVEMP reflexes bilaterally, 2 (7%) had absent oVEMP reflexes unilaterally, and one (3%) had decreased oVEMP amplitudes unilaterally. In 2 patients prolonged oVEMP latencies were observed. No significant correlation was observed among cVEMP, oVEMP and the caloric test. This study showed abnormal vestibular reflexes could be shown by oVEMP as well as the caloric test and cVEMP. It was suggested that a portion of those patients with MAV have abnormal otolith-ocular reflexes.

著者

小宮山 櫻子 中原 はるか 津田 幸子 吉村 恵理子 室伏 利久

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.72, no.6, pp.493-500, 2013-12-31 (Released:2014-02-01)

参考文献数

17

被引用文献数

2 2

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The purposes of this study was to elucidate the clinical characteristics of patients suffering from migraine-associated vertigo (MAV) including results of cervical vestibular evoked myogenic potential (cVEMP) and ocular VEMP (oVEMP). Thirty patients diagnosed as having MAV based on the diagnostic criteria by Sakata et al. were enrolled. We performed a retrospective chart review. These patients underwent medical history taking and examinations including cVEMP, oVEMP and a caloric test. All examinations were performed during a symptom-free interval. Twenty one patients (70%) experienced rotatory vertigo, 5 patients (17%) had floating dizziness and 4 patients (13%) had both. Twenty six patients (87%) reported tinnitus and/or aural fullness unilaterally or bilaterally. Their vertigo or dizziness lasted under 60 minutes in 10 patients (34%), 1 hour to 24 hours in 14 patients (46%), and over one day in 5 patients (17%). Canal paresis in the caloric test was observed in 5 patients (17%). Concerning cVEMP, 4 of the 30 patients (13%) showed absent cVEMPs bilaterally, 2 patients (7%) showed absent cVEMPs reflexes unilaterally, and one (3%) demonstrated decreased cVEMP amplitudes unilaterally. Only one patient showed prolonged cVEMP latencies. Concerning oVEMP, 6 of the 30 patients (20%) had absent oVEMP reflexes bilaterally, 2 (7%) had absent oVEMP reflexes unilaterally, and one (3%) had decreased oVEMP amplitudes unilaterally. In 2 patients prolonged oVEMP latencies were observed. No significant correlation was observed among cVEMP, oVEMP and the caloric test. This study showed abnormal vestibular reflexes could be shown by oVEMP as well as the caloric test and cVEMP. It was suggested that a portion of those patients with MAV have abnormal otolith-ocular reflexes.

著者

吉村 恵

出版者

平安女学院大学

雑誌

平安女学院短期大学教育研究所年報 (ISSN:13403532)

巻号頁・発行日

vol.5, pp.1-17, 1998-03