著者
洲崎 春海 野村 恭也 水野 正浩 川端 五十鈴 田部 浩生 宮川 晃一 坪井 洋 鳥山 稔 飯野 ゆき子 中井 淳仁 市村 恵一 土田 みね子 中村 直也 山口 宏也 深谷 卓 安部 治彦 井上 都子 杉本 正弘 鈴木 康司 佐藤 恒正 大西 信治郎 小林 恵子 伊藤 依子 井上 憲文 小林 武夫 室伏 利久 水野 信一 鳥山 寧二 飯塚 啓介 市川 朝也 森田 守 石井 哲夫 鍋島 みどり 船井 洋光 浅野 恵美子 矢野 純 吉見 健二郎 横川 友久
出版者
耳鼻咽喉科展望会
雑誌
耳鼻咽喉科展望 (ISSN:03869687)
巻号頁・発行日
vol.34, no.Supplement7, pp.575-581, 1991-10-15 (Released:2011-08-10)
参考文献数
9

12歳以上のスギ花粉症患者118例 (男55例, 女63例) にトラニラスト (リザベン ®) を投与し, 予防効果と治療効果について比較, 検討した。投与方法はトラニラストとして1日300mgを原則としてスギ花粉飛散 (20個/cm2/日以上の飛散) の2週間以前から投与し (予防投与), 飛散後4週間継続投与した (治療投与)。改善度判定は,「効果あり」以上は予防投与群32例 (57%), 治療投与群28例 (45%) で,「やや効果あり」以上は予防投与群42例 (75%), 治療投与群49例 (79%) であった。花粉飛散初期において鼻症状, 鼻鏡所見, 眼症状のいずれの程度も治療投与群に比べて予防投与群の方が有意に改善しており, 自覚症状, 他覚所見のいずれもトラニラストの予防効果が認められた。治療投与群においてはくしゃみ, 鼻汁, 鼻鏡所見, 眼のかゆみの程度が投与終了時に有意に改善した。副作用は予防投与群4例 (7.1%) 治療投与群5例 (8.1%) にみられたがいずれも投与中または投与中止により軽快した。以上より, トラニラストの予防投与は有用でかつ合理的な治療法と考えられる。また, 治療投与も有用であることが確認された
著者
五島 史行 室伏 利久
出版者
一般社団法人 日本めまい平衡医学会
雑誌
Equilibrium Research (ISSN:03855716)
巻号頁・発行日
vol.74, no.4, pp.299-301, 2015-08-31 (Released:2015-10-01)
参考文献数
6
被引用文献数
2
著者
小宮山 櫻子 中原 はるか 津田 幸子 吉村 恵理子 室伏 利久
出版者
一般社団法人 日本めまい平衡医学会
雑誌
Equilibrium Research (ISSN:03855716)
巻号頁・発行日
vol.72, no.6, pp.493-500, 2013
被引用文献数
2

The purposes of this study was to elucidate the clinical characteristics of patients suffering from migraine-associated vertigo (MAV) including results of cervical vestibular evoked myogenic potential (cVEMP) and ocular VEMP (oVEMP). Thirty patients diagnosed as having MAV based on the diagnostic criteria by Sakata et al. were enrolled. We performed a retrospective chart review. These patients underwent medical history taking and examinations including cVEMP, oVEMP and a caloric test. All examinations were performed during a symptom-free interval. Twenty one patients (70%) experienced rotatory vertigo, 5 patients (17%) had floating dizziness and 4 patients (13%) had both. Twenty six patients (87%) reported tinnitus and/or aural fullness unilaterally or bilaterally. Their vertigo or dizziness lasted under 60 minutes in 10 patients (34%), 1 hour to 24 hours in 14 patients (46%), and over one day in 5 patients (17%). Canal paresis in the caloric test was observed in 5 patients (17%). Concerning cVEMP, 4 of the 30 patients (13%) showed absent cVEMPs bilaterally, 2 patients (7%) showed absent cVEMPs reflexes unilaterally, and one (3%) demonstrated decreased cVEMP amplitudes unilaterally. Only one patient showed prolonged cVEMP latencies. Concerning oVEMP, 6 of the 30 patients (20%) had absent oVEMP reflexes bilaterally, 2 (7%) had absent oVEMP reflexes unilaterally, and one (3%) had decreased oVEMP amplitudes unilaterally. In 2 patients prolonged oVEMP latencies were observed. No significant correlation was observed among cVEMP, oVEMP and the caloric test. This study showed abnormal vestibular reflexes could be shown by oVEMP as well as the caloric test and cVEMP. It was suggested that a portion of those patients with MAV have abnormal otolith-ocular reflexes.
著者
室伏 利久
出版者
一般社団法人 日本めまい平衡医学会
雑誌
Equilibrium Research (ISSN:03855716)
巻号頁・発行日
vol.77, no.6, pp.525-531, 2018-12-31 (Released:2019-02-01)
参考文献数
21

The history of clinical studies on vestibular migraine (migraine associated vertigo) was reviewed. Archeological studies suggested that headache itself had already existed in the Neolithic era, because bony defects in the skull which could have arisen from trepanation had been found in the remains of this era. Medical observations on migraine were made by Hippocrates of Kos, and Aretaeus of Kappadocia described migraine-associated vertigo in the 2nd century A.D. Studies on migraine and migraine-associated vertigo (vestibular migraine) began in the modern era. As hypotheses on the pathophysiology of migraine, three theories have been proposed, including the vascular theory, the neural theory, and the trigemino-vascular theory. As important articles concerning the clinical studies, three papers were published. The first was published by Bickerstaff. He reported cases of basilar-type migraine, in which vertigo occurs as an aura of migrainous headache. The second was published by Kayan and Hood. In this paper, the authors described various characteristics of vestibular migraine, which are still valid. The third was published by Neuhauser et al., in which the authors proposed diagnostic criteria for vestibular migraine, which serve as the basis for the current official diagnostic criteria. Finally, the author remarked that clarification of the pathophysiology of vestibular migraine and association with Meniere's disease are the most important issues that need to be resolved.
著者
八木 昌人 尾関 英徳 井上 亜希 中西 重夫 室伏 利久
出版者
一般社団法人 日本聴覚医学会
雑誌
AUDIOLOGY JAPAN (ISSN:03038106)
巻号頁・発行日
vol.54, no.1, pp.56-62, 2011 (Released:2011-04-16)
参考文献数
9
被引用文献数
1

250Hzから4000Hzまでの5周波数聴力閾値の平均が40dB未満 (grade1) の突発性難聴症例について検討した。高度の感音難聴ではないことから, 突発性難聴以外にオージオグラムの型により急性低音障害型感音難聴, 急性感音難聴といった診断がなされており, 担当医の違いにより診断が影響されていた。予後については, 治癒率は66%であったが, 著明回復は1例も見られなかった。これは, 著明回復が30dB以上の改善と定義されているためで, grade1ではこれは治癒と重なってしまうためと考えられた。突発性難聴にgrade1症例を含めるかどうかの是非を含め, 難聴の程度に応じた診断基準, 聴力回復の判定基準の作成が望まれた。
著者
坂田 阿希 中原 はるか 室伏 利久
出版者
一般社団法人 日本めまい平衡医学会
雑誌
Equilibrium Research (ISSN:03855716)
巻号頁・発行日
vol.67, no.1, pp.13-17, 2008 (Released:2008-05-02)
参考文献数
14

Intratympanic instillation of gentamicin is currently a well-established treatment for intractable vertigo in patients with Meniere's disease. There are, however, only a few reports of this therapy in patients with non-Meniere type of vertigo. We report the case of a 68-year-old woman with the lateral semicircular canal type of benign paroxysmal positional vertigo (BPPV) following right idiopathic sudden hearing loss. The patient was annoyed by the positional vertigo for one and a half years and was successfully treated by intratympanic gentamicin instillation. She had profound hearing loss on the right side and direction-changing apogeotropic positional nystagmus. Her caloric response on the right side was severely decreased (canal paresis 80%). Intratympanic gentamicin instillation therapy was undertaken (30mg/ml/day × 5 days), following which her positional vertigo was abolished. We propose that intratympanic instillation of gentamicin may also be applicable to selected patients with long-lasting BPPV.
著者
小宮山 櫻子 中原 はるか 津田 幸子 吉村 恵理子 室伏 利久
出版者
一般社団法人 日本めまい平衡医学会
雑誌
Equilibrium Research (ISSN:03855716)
巻号頁・発行日
vol.72, no.6, pp.493-500, 2013-12-31 (Released:2014-02-01)
参考文献数
17
被引用文献数
2 2

The purposes of this study was to elucidate the clinical characteristics of patients suffering from migraine-associated vertigo (MAV) including results of cervical vestibular evoked myogenic potential (cVEMP) and ocular VEMP (oVEMP). Thirty patients diagnosed as having MAV based on the diagnostic criteria by Sakata et al. were enrolled. We performed a retrospective chart review. These patients underwent medical history taking and examinations including cVEMP, oVEMP and a caloric test. All examinations were performed during a symptom-free interval. Twenty one patients (70%) experienced rotatory vertigo, 5 patients (17%) had floating dizziness and 4 patients (13%) had both. Twenty six patients (87%) reported tinnitus and/or aural fullness unilaterally or bilaterally. Their vertigo or dizziness lasted under 60 minutes in 10 patients (34%), 1 hour to 24 hours in 14 patients (46%), and over one day in 5 patients (17%). Canal paresis in the caloric test was observed in 5 patients (17%). Concerning cVEMP, 4 of the 30 patients (13%) showed absent cVEMPs bilaterally, 2 patients (7%) showed absent cVEMPs reflexes unilaterally, and one (3%) demonstrated decreased cVEMP amplitudes unilaterally. Only one patient showed prolonged cVEMP latencies. Concerning oVEMP, 6 of the 30 patients (20%) had absent oVEMP reflexes bilaterally, 2 (7%) had absent oVEMP reflexes unilaterally, and one (3%) had decreased oVEMP amplitudes unilaterally. In 2 patients prolonged oVEMP latencies were observed. No significant correlation was observed among cVEMP, oVEMP and the caloric test. This study showed abnormal vestibular reflexes could be shown by oVEMP as well as the caloric test and cVEMP. It was suggested that a portion of those patients with MAV have abnormal otolith-ocular reflexes.
著者
加我 君孝 室伏 利久
出版者
東京大学
雑誌
特定領域研究(A)
巻号頁・発行日
1998

聴性脳幹反応(ABR)の難聴乳幼児の早期発見のための臨床応用が広く普及するようになった結果、わが国では0才のうちに難聴児が発見されるようになった。同時に0才のうちに補聴器のフィッティングを行い、超早期教育が行われるようになった。我々はこの難聴乳幼児の早期発見、早期教育に過去20年取り組んできた。その成果は著しく、2才前後での言語獲得がなされ就学後は普通学校に入学し、高等教育を受けるに至る場合も少なくなくなってきた。これらの症例を対象とする乳幼児の喃語や言語に関する研究は極めて少ない。早期発見された難聴乳幼児の始語に至る0〜1才の間の発達と音声の変化の関係について、他覚的に明らかにすべく音響分析を行った。対象:0〜1才の正常乳児3例とABR他の検査で高度難聴の証明された5例方法:ビデオカメラで、喃語を行動の記録とともに録音し、それをサウンドスペクトルグラフで解析した。結果:1)代表的な高度難聴乳幼児の発達と喃語および音声の変化を図1にまとめて記述解説し、サウンドスペクトルグラフによる解析の例を生後11ヶ月の“あー"を図2、生後19ヶ月の“あうーん"を図3に示した。2)対象例も難聴乳児もサウンドスペクトルグラフによる解析では、ほぼ同様のパターンを示した。異なる部分も一部に認めた。