著者

熊谷 岳文 楢原 菜穂子 佐藤 英治 木平 孝高 藤村 よしの 小嶋 英二朗 小川 祥二郎 伊達 有子 鶴田 泰人 吉富 博則 井上 裕文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.141, no.4, pp.599-610, 2021-04-01 (Released:2021-04-01)

参考文献数

14

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Elneopa NF No. 1 and No. 2 infusions are total parenteral nutrition solutions packaged in four-chambered infusion bags. They have been used as home parenteral nutrition, with various drugs injected into the infusion bags, for treating patient symptoms. In this study, we investigated the stability of six drugs, including famotidine, scopolamine butylbromide, furosemide, bromhexine hydrochloride, betamethasone sodium phosphate, and metoclopramide hydrochloride in the infusion bags under dark conditions at 4℃ for 7 days. Additionally, we developed a high-performance liquid chromatography method to determine drug concentrations in the infusions. The concentrations of injected famotidine, scopolamine butylbromide, and betamethasone sodium phosphate remained unchanged when the four chambers of Elneopa NF No. 1 and No. 2 were opened and the infusions were mixed. Their respective concentrations in the upper and lower chambers also remained unchanged. The concentration of furosemide in the upper chamber of the No. 1 infusion bag decreased after 5 days, although no change was observed in the other chambers and the mixed infusions with the four chambers opened. The concentration of bromhexine hydrochloride slightly decreased in the upper chambers (approximately 3%) after the co-infusion but decreased significantly in the other chambers and the mixed infusions with the four chambers opened. The concentration of metoclopramide hydrochloride significantly decreased in the upper chambers after the co-infusion; however, no change in concentration was observed in the other chambers and the mixed infusion with the four chambers opened. The results of this study provide useful information on home-based parenteral nutrition.

著者

小川 祥 渡辺 貴志 庄司 さやか 降旗 千惠

出版者

日本環境変異原学会

雑誌

日本環境変異原学会大会プログラム・要旨集

巻号頁・発行日

no.43, 2014

著者

亀田 秀人 小川 祥江 鈴木 勝也 長澤 逸人

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.98, no.10, pp.2506-2511, 2009 (Released:2012-08-02)

参考文献数

9

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シクロスポリン(CsA)とタクロリムス(Tac)は,カルシニューリンの脱リン酸化酵素活性阻害を介したT細胞の活性化制御を主作用とする薬剤である.CsAはシクロフィリン,TacはFKBP12と結合して作用を発揮するという相違もあって,2つの薬剤の副作用や疾患に対する効果に差異が見られる.難治性病態に対しては,従来の核酸代謝拮抗薬との併用療法の有用性が期待されている.