著者

岸 玲子 荒木 敦子 宮下 ちひろ 伊藤 佐智子 湊屋 街子 小林 澄貴 山﨑 圭子 アイツバマイ ゆふ 三浦 りゅう 田村 菜穂美

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.73, no.2, pp.164-177, 2018 (Released:2018-05-31)

参考文献数

69

被引用文献数

2

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Since “Our Stolen Future” by Theo Colborn was published in 1996, global interest on the impact of chemical substances, such as the endocrine-disrupting action of chemicals, has increased. In Japan, “The Hokkaido Study on Environment and Children’s Health: Malformation, Development and Allergy” was launched in 2001. It was a model of Japan Environment and Children’s Study of the Ministry of the Environment. In a large-scale, Hokkaido cohort, we obtained the consent of 20,926 mothers at the organogenesis stage with the cooperation of 37 obstetrics clinics in Hokkaido. We tracked the effects of endocrine disruptors on developmental disorders. In a small-scale Sapporo cohort, we observed in detail the neuropsychiatric development of children with the consent of 514 mothers in their late pregnancy. We examined how prenatal exposure to low concentrations of environmental chemicals affect the development of organs and the postnatal development of children. Maternal exposure to POPs, such as PCB/dioxins and perfluorinated alkyl substances, has affected not only children’s birth size, thyroid functions, and sex hormone levels, but also postnatal neurodevelopment, infection, and allergy among others. The associations of short-half-life substances, such as DEHP and BPA, with obesity, ASD, and ADHD have been investigated. Gene-environment interactions have been found for smoking, caffeine, folic acid, and PCB/dioxin. In 2015, our center was officially designated as the WHO Collaborating Centre for Environmental Health and Prevention of Chemical Hazards, and we continue to the contribute to the global perspectives of child health.

著者

小林 澄貴

出版者

北海道大学

雑誌

研究活動スタート支援

巻号頁・発行日

2014-08-29

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研究デザインは、出生前向きコホート内症例対照研究である。2003-2007年に生まれた8歳児のうちADHD-RS得点が得られた3,263名のうち、児の性別と母の出産年齢でマッチングさせ1,491名抽出したところ、非喫煙群552名、受動喫煙群812名、喫煙群127名となった。ロジスティック回帰分析で検討したところ、非喫煙群と比較して、受動喫煙群から生まれた8歳児のADHD疑いになるオッズ比は1.17倍高かったものの有意ではなかった(95%CI; 0.84-1.63)。妊娠中の母の受動喫煙曝露が8歳児のADHDのリスク増加に影響を及ぼさず、そして遺伝環境交互作用も関与しないと考えられた。