著者

上田 恵子 辻森 めぐみ 小谷 真也 千葉 亜希子 増野 和彦 久保 昌一 長井 薫 関谷 敦 河岸 洋和

出版者

天然有機化合物討論会実行委員会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

vol.50, pp.309-314, 2008

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The importance of the endoplasmic reticulum (ER) in triggering a specific program of cell death has been recently reported. By triggering apoptosis on neural cells, ER-stress is a major cause of neurodegenerating disease such as Alzheimer disease. The demand for new protective substances to the ER-stress-dependent cell death prompted us to screen the protective activity of mushrooms. On the course of the screening, we isolated new hericenones, 3-hydroxy-hericenone F as a protective agent, along with related compounds, hericenone I and J. The structures of hericenones were determined by NMR and MS spectra. The structure of 3-hydroxy hericenone was elucidated as (8-formyl-3-hydroxy-5-methoxy-2-methyl-2-(4'-methyl-2'-oxopent-3'-enyl) chroman-7-yl) methyl palmitate, which had one additional hydroxy group compared to hericenone F. 3-Hydroxy-hericenone F showed the protective activity dose-dependently, however hericenones F, I and J did not have any activity at the concentration of 10μg/mL. Therefore, we suggested that the hydroxy group of 3-hydroxy-hericenone F was important for the protective activity. This is the first report of a new hericenone which has the protective activity against ER stress-dependent cell death. The further study using more hericenones is needed for the understanding of the structure-activity relationship.