著者

久保 道徳 山崎 美保 松田 秀秋 我藤 伸樹 小谷 竜也

出版者

日本生薬学会

雑誌

生薬學雜誌 (ISSN:13403443)

巻号頁・発行日

vol.59, no.1, pp.22-27, 2005-02-20

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The effect of a fruit-juice concentrate of Japanese apricot (Japanese apricot concentrate, Ume-ekisu) on improving blood fluidity was examined. Whole blood passage time measured by a micro channel array flow analyzer (MC-FAN) of the Japanese apricot concentrate (200 mg/kg, p.o.)-treated rats was shorter than that of the non-treated control rats. Thus Japanese apricot concentrate showed an improving effect on rat blood fluidity. Furthermore, it was found that the Japanese apricot concentrate showed inhibitory effects on the collagen-, arachidonic acid- and ADP-induced platelet aggregations and on the thrombin-induced conversion of fibrinogen to fibrin. Citric acid and mumefural were identified as the main platelet aggregation inhibitory principles of Japanese apricot concentrate.