著者

山本 樹 山田 勝久 鈴木 信孝 許 鳳浩 高橋 正征

出版者

日本補完代替医療学会

雑誌

日本補完代替医療学会誌 (ISSN:13487922)

巻号頁・発行日

vol.15, no.2, pp.67-77, 2018-09-30 (Released:2018-10-12)

参考文献数

84

被引用文献数

1

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海洋深層水(Deep Sea Water: DSW)とは200m以深に存在する海水である.海洋深層水の豊富なミネラル分, 清浄性, 富栄養性といった特性を活かした産業利用では, 日本が最先端を行っている.また, 海洋深層水の資源活用, とくに未病や予防医学への応用についても世界中から注目を集めるようになった.そこで今回, 特に, 生活習慣病である脂質異常症, 高血圧症, 糖尿病, 動脈硬化症をはじめ, アトピー性皮膚炎, 骨粗鬆症, がん, 消化性潰瘍, 白内障, 便秘症における海洋深層水の基礎・臨床医学研究成果をレビューしたので報告する.

著者

内川 幸昭 山田 勝久

出版者

社団法人空気調和・衛生工学会

雑誌

学術講演会論文集

巻号頁・発行日

no.62, pp.325-328, 1987-10-06

著者

堤 竹蔵 今井 俊吾 山田 勝久 山田 武宏 笠師 久美子 小林 正紀 井関 健

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.139, no.7, pp.1055-1061, 2019-07-01 (Released:2019-07-01)

参考文献数

20

被引用文献数

2

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Linezolid (LZD), an antimicrobial agent against methicillin-resistant Staphylococcus aureus, demonstrates good bone and joint penetration, and is used for prosthetic bone and joint infections. Recently, we observed vomiting in several patients administered LZD. However, there are few reports on the incidence rate of, and risk factors for, LZD-induced nausea and vomiting. In this study, we aimed to verify the relationship between LZD administration and vomiting. Patients administered LZD at the Department of Orthopedic Surgery of Hokkaido University Hospital between November 2008 and December 2017 were enrolled in the study. The primary endpoint was the comparison of the vomiting rate between patients administered LZD (LZD group) and those administered other antibiotics (non-LZD group). For the secondary endpoint, to verify the risk factors of vomiting, a univariate logistic regression analysis was performed. In total, 130 patients were included in this study; 77 patients in the LZD group, and 53 in the non-LZD group. Vomiting occurred in 18 patients in the LZD group and 4 patients in the non-LZD group (23.4% and 7.5%, respectively); this was significantly higher in the LZD group. In the univariate logistic regression analysis, LZD administration, gender (female), age ≥65 years, renal impairment (creatinine clearance <60 mL/min) and concomitant use of rifampicin were extracted as potential risk factors of vomiting. The results of this study reveal a possible relationship between LZD administration and vomiting.