著者

山辺 晋吾 片山 和明 望月 眞人

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.65, no.5, pp.497-511, 1989-05-20 (Released:2012-09-24)

参考文献数

21

被引用文献数

1 1

---

In order to investigate the role of progesterone in the maintenance of pregnancy, an anti-progesterone agent, RU486 (RU) was injected subcutaneously into pregnant rats on day12 (D12), and morphological changes of the uterus as well as endocrinological changes were observed.In all rats injected with RU, abortion occurred with macroscopic and microscopic intrauterine hemorrhage and degeneration or delivery of conceptuses. Endocrinologically, the levels of progesterone decreased rapidly 48 hours after the injection, while the levels of estradiol showed a tendency to increase.As progesterone is mainly produced by the corpus luteum but not by the placenta in rats, the decrease in progesterone is suspected to be due to luteolysis. Then in order to clarify the mechanism of luteolysis induced by RU and the effects of progesterone on this phenomenon, the dynamics of the luteotrophic factors (estradiol, LH, PRL) and specific binding capacity of the ovaries to LH/hCG were investigated in D7 pregnant rats treated with RU 1 mg/kg alone (RU group) or with both RU 1mg/kg and progesterone 50mg/kg (RU+P group).The serum levels of progesterone in the RU group decreased significantly after 72 hours of administration, while those in the RU+P group remained within the levels of the control group. However, serum levels of luteotrophic factors in the RU group did not de-crease, and some of them were even higher than those in the control group. In the RU+P group, luteotrophic factors remained within control levels.On the other hand, the specific bindings of LH/hCG to ovarian homogenates decreased significantly after 72 hours in the RU group. But in the RU+P group, the specific bindings were kept at the same levels as the controls. Scatchard analysis of these results disclosed that in the RU group, both affinity and numbers of receptors decreased compared to the controls, and that in the RU+P group only affinity decreased transiently and afterwards recovered quickly.From these results, it is concluded that deterioration of affinity and numbers of ovarian LH/hCG receptors seems to be one of the factors which induce luteolysis in pregnant rats treated with RU, and that progesterone can spare the effect of RU on the corpus luteum during pregnancy.

著者

奥 久人 平井 光三 浅原 彩子 川又 靖貴 峯 眞紀子 山中 美樹子 山辺 晋吾 出田 和久

出版者

日本産科婦人科学会

雑誌

日本産科婦人科學會雜誌

巻号頁・発行日

vol.67, no.2, 2015

著者

本山 覚望 望月 愼介 竹内 聡 赤山 由起 山辺 晋吾 丸尾 猛

出版者

Japanese College of Surgeons

雑誌

日本外科系連合学会誌 (ISSN:03857883)

巻号頁・発行日

vol.25, no.1, pp.61-65, 2000-02-29 (Released:2009-08-13)

参考文献数

20

---

目的 : 人工造腟術として, 酸化セルロース製の組織代用人工繊維布 (TC7) を新腟腔へ添付し, 腟本来の扁平上皮粘膜の新生誘導を検討した。方法 : 6例の先天性腟欠損症に対し, 腟前庭粘膜の十字切開により解剖学的腟経に沿い子宮下部に達する新腟腔を形成した。切開で生じた4点の腟前庭粘膜縁を新腟腔内壁へ縫合後, TC7で包まれた膣型を新腟腔へ充填し手術を終了した。成績 : 平均手術時間は25.8分, 平均出血量は14.2ml, 入院期間は2日, 合併症発生率は0%であった。全例において, 術後2~5カ月で添付TC7膜下で腟前庭粘膜縁より新生した重層扁平上皮で新腟腔全域は被覆された。また, 新生腟扁平上皮粘膜は正常腟粘膜と同様に卵巣周期に呼応した分泌能と形態の変化を示した。結論 : 本法は現行造腟法と比較して低侵襲性でDay Surgeryも可能であり, また, 本法の腟粘膜は腟本来の自然性を示すため, 患者QOLの向上に役立つものと思われる。