著者

岩井 譲

出版者

公益社団法人 日本農芸化学会

雑誌

化学と生物 (ISSN:0453073X)

巻号頁・発行日

vol.54, no.1, pp.7-9, 2015-12-20 (Released:2016-12-20)

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私が28歳のとき北里研究所(北研)で出会ってから今日までご指導をいただいている大村 智北里大学特別栄誉教授との思い出を含め,エバーメクチンの発見と開発について書かせていただく.

著者

岩井 譲 志水 秀樹 大村 智

出版者

公益社団法人 日本農芸化学会

雑誌

化学と生物 (ISSN:0453073X)

巻号頁・発行日

vol.23, no.6, pp.379-385, 1985

被引用文献数

1

著者

岩井 譲

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.28, no.11, 1992

著者

岩井 譲 大村 智 秦 藤樹

出版者

日本醗酵工学会

雑誌

醗酵工学雑誌 (ISSN:03675963)

巻号頁・発行日

vol.49, no.10, pp.842-846, 1971-10

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In the course of various fermentations for the production of antibiotics by Streptomyces sp., glycerol, as well as glucose, has been found to be a preferred carbon source. In order to determine glycerol in the fermentation broth, a colorimetric method based on the procedures described by West was modified with respect to the condition of oxidation of glycerol by periodic acid. It has been found that, under a mild condition of periodic acid oxidation at 0 ℃ for 30 min, glycerol can be determined even when glucose is present. This method was applied in the practical production of three antibiotics : cycloserine, echinomycin, and streptomycin, and the following results were obtained : (1) The metabolism of glycerol was more active than that of glucose or starch; during each fermentation, the glycerol in the medium was nearly consumed after 45 hours.(2) The peak of antibiotic production in fermented broth appeared after the glycerol consumption was completed.