著者

村嶋 正幸 成田 有吾 岩崎 英一 橋爪 永子 出口 晃 西川 政勝 出口 克巳 白川 茂

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.3, no.6, pp.392-398, 1992-08-01 (Released:2010-08-05)

参考文献数

13

被引用文献数

2 2

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The effect of a novel compound, 3-isobutyryl-2-isopropylpyrazolo [1, 5-a] pyridine (ibudilast, KC-404), on human platelet aggregation and its mechanism of action were investigated.In vitro, KC-404 inhibited human platelet aggregation induced by ADP, collagen, adrenalin, platelet activating factor and arachidonic acid but not by ristocetin. Together, KC-404 and agents which increased cAMP (prostaglandin I2, prostaglandin E1 (PGE1), forskolin) or cGMP (3-morpholinosydnonimine (SIN-1)) produced synergistic inhibitory effects on platelet aggregation.KC-404 inhibited human platelet cAMP phosphodiesterase (PDE) (IC50: 50μM) and cGMP-PDE (IC50: 5.2μM) activities. cAMP and cGMP concentration of human platelets were not increased by KC-404 itself. PGE1, an adenylate cyclase stimulator, increased cAMP content; KC-404 enhanced the effect of PGE1 on cAMP accumulation. SIN-1, which stimulates guanylate cyclase, increased cGMP content; KC-404 enhanced the effect of SIN-1 on cGMP accumulation.These results suggest that effects of KC-404 on accumulation of cyclic nucleotides and inhibition of platelet aggregation are mediated via inhibition of platelet cyclic nucleotide phosphodiesterase activities.

著者

寺田 裕樹 成田 有吾 久田 雅紀子 種田 ゆかり 今井 奈妙 Terada Yuki Narita Yugo Hisada Akiko Taneda Yukari Imai Nami

出版者

三重大学医学部看護学科

雑誌

三重看護学誌 (ISSN:13446983)

巻号頁・発行日

vol.13, pp.73-81, 2011-03-15

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目的:看護大学生の感じているストレスと学習意欲・態度への影響を検討. 対象:看護学科4年生82名. 方法:学習意欲尺度(加曽利,2008)を含む調査票で検討した. 結果:1)[集中力・持続力因子]の10項目中7項目で「はい」回答者群のストレス度が有意に高かった.2)[自己向上因子]では,5項目中2項目で「いいえ」回答者群はストレス度が有意に高かった.3)ストレス度による学習意欲の変化は,4因子すべてにおいて有意差は認められなかった.4)各因子の項目間では,「遅刻・欠席が多い」ことは[授業に対する積極性因子]以外の負の3因子の項目との関連が示唆された.5)学習意欲尺度の各項目間では,7組の項目で遅刻や欠席の少なさとの関係が示唆された. 結論:1)~5)の結果より,本対象では,[集中力・持続力因子],[自己向上因子]および[授業に対する真面目さ因子]においてストレスとの関係が示唆された.This study surveyed effects of stress on learning motivation of 82 student-nurses at 4 th grade by a questionnaire including a learning motivation scale(Kasori T, 2009). The result suggested following 5 points;1)Positive respondents(who said Yes)on 7 out of 10 items concerning concentration and its endurance showed higher stress level than negative respondents(who said No)did.2)Negative respondents on 2 out of 5 items concerning self-efficacy and its improving motivation showed higher stress level than positive respondents did.3)No relationship between learning motivation and stress levels appeared in 4 stress factors.4)Students who answered as they had tended to be late or absent seemed to have much stress and negative responses at 3 items concerning active factors on learning at a class.5)Tendency of less late or absence seemed to relate each item of learning desire scales significant relation between seven items. In conclusion, 〔concentration and its endurance〕 and 〔self-efficacy and its improving motivation〕 may concern the stress of the student nurses.

著者

服部 純子 今井 奈妙 成田 有吾 Hattori Junko Imai Nami Narita Yugo

出版者

三重大学大学院医学系研究科看護学専攻

雑誌

三重看護学誌 = Mie Nursing Journal (ISSN:13446983)

巻号頁・発行日

vol.20, pp.25-32, 2018-03-26

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The purpose of this study was to clarify the difficulty with respect to family relationships experienced by Multiple Chemical Sensitivity (MCS) patients, by analyzing the contents of illness which MCS patients described.We conducted and analyzed qualitatively a semi-structured interview on "The pain of living" with respect to family relationships for five female MCS patients in their 40s to 50s.The difficulty of living with respect to family relationships reported by MCS patients consisted of six categories: " Confusion about families who do not understand ", "embarrassment about living with family", "give up on family’s understand ", "being hurt by family’s behavior", " anger against family" and "collapse of family relationships".The results of this study revealed psychological conflicts related to the family relationship of MCS patients on the characteristic care of MCS such as to avoid exposure to chemical substances. These psychological conflicts were the cause of social distress in MCS patients, and they were the core of these patients’ painfulness of living.