著者

杉山 昌秀 青木 悠 篠原 佳祐 宮田 智陽 関口 展貴

出版者

一般社団法人 日本農村医学会

雑誌

日本農村医学会雑誌 (ISSN:04682513)

巻号頁・発行日

vol.67, no.4, pp.512, 2018 (Released:2018-12-18)

参考文献数

4

---

潰瘍性大腸炎に対するタクロリムスの治療は,早期に高トラフ値に保つことの重要性が示唆されている。我々は添付文書より多い初期投与量で開始し,連日TDMによる用量調節を行なった2症例について検討を行なった。2症例とも10~15ng/mLの高トラフ域を維持されることで症状の改善が認められた。高トラフ域に入ったのが開始後9日目であり,添付文書の投与法と同程度の日数を要した。

著者

青木 悠 杉山 昌秀 依田 一美 星野 明子 跡部 治

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.37, no.6, pp.371-376, 2011 (Released:2012-08-25)

参考文献数

14

被引用文献数

1 1

---

When lansoprazole orally dispersing tablets (30 mg) are administered through a tube, a residue often remains in the syringe and tube because the tablets contain fine enteric granules which are nearly insoluble in water. As a solution, we added thickening agents and examined their effectiveness in reducing the residue in syringes.The amount of lansoprazole residue in syringes was 11.4±1.3 mg when the agents were not added (Group A) and 1.3±0.6 mg when the agents were added (Group B). For Group A, the residue from a single injection was approximately 30-40% of the total amount of lansoprazole, while there was almost no lansoprazole residue for Group B. Performed by nurses, tube administration took slightly longer for Group B - 51.4±5.5 sec for Group A and 70.8±6.1 sec for Group B.Our solution of just adding thickening agents improved the dispersivity of the drug in the suspension as well as the mobility of the drug suspension, by getting the particles and solvent traveling at the same speed. It enabled injection to be performed smoothly and decreased the amount of residue in the syringe. The addition of thickening agents is therefore useful in tube administration because avoiding any lansoprazole loss would help ensure that the expected efficacy is achieved, since this is dosedependent.