1 0 0 0 OA 十字路
- 著者
- 関 雅彦 周東 智 竹内 義雄 石井 昭彦
- 出版者
- 社団法人 有機合成化学協会
- 雑誌
- 有機合成化学協会誌 (ISSN:00379980)
- 巻号頁・発行日
- vol.55, no.10, pp.928-928, 1997 (Released:2009-11-16)
1 0 0 0 OA ピラノースの配座制御に基づく立体選択的グリコシル化反応
- 著者
- 周東 智 市川 聡 阿部 洋 松田 彰
- 出版者
- The Society of Synthetic Organic Chemistry, Japan
- 雑誌
- 有機合成化学協会誌 (ISSN:00379980)
- 巻号頁・発行日
- vol.66, no.1, pp.50-60, 2008-01-01 (Released:2010-06-28)
- 参考文献数
- 22
- 被引用文献数
- 2 4
Despite considerable progress and extensive effort, a general method for highly stereoselective glycosylation particularly for the 1, 2-cis-glycosylation has not yet been developed and therefore is required. The α/β-stereoselectivity in glycosylation can be affected by the steric and stereoelectronic (anomeric) effects around the anomeric center, which depend on the conformation of the glycosyl donor substrates. Therefore, we hypothesized that highly α- and β-selective glycosylation can be realized by employing conformationally restricted substrates. We showed that the α/β-stereoselectivity was significantly increased by the conformational restriction and was completely inverted by changing the substrate conformation from the 4C1-form into the 1C4-form in radical and nucleophilic C-glycosylation reactions as well as in O-glycosylation reactions. The conformational restriction of substrates also effectively facilitates the α- and β-selective radical cyclization reaction at the anomeric position. Using the method, C-glucoside trisphosphates designed as Ca2+-mobilizing agents were successfully synthesized.
1 0 0 0 IR 国語科教員養成課程で出会う『枕草子』
- 著者
- 坂東 智子
- 出版者
- 山口大学教育学部附属教育実践総合センター
- 雑誌
- 教育実践総合センター研究紀要 (ISSN:13468294)
- 巻号頁・発行日
- no.37, pp.37-45, 2014