2 0 0 0 OA 胎児におけるシトクロムP450の発現―肝臓のCYP3A分子種を中心として―
- 著者
- 松永 民秀 丸山 昌孝 大森 栄
- 出版者
- The Shinshu Medical Society
- 雑誌
- 信州医学雑誌 (ISSN:00373826)
- 巻号頁・発行日
- vol.56, no.1, pp.7-16, 2008 (Released:2012-05-28)
- 参考文献数
- 51
2 0 0 0 OA 市販の大麻種子中のカンナビノイドの定量とその薬毒理作用
- 著者
- 松永 民秀 渡辺 和人 吉村 英敏 山本 郁男
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- 藥學雜誌 (ISSN:00316903)
- 巻号頁・発行日
- vol.118, no.9, pp.408-414, 1998-09-01
△^9-Tetrahydrocannabinol (△^9-THC), cannabinol, cannabidiol and cannabichromene were detected in commercially available cannabis seeds by silica gel TLC and gas chromatography. These cannabinoids existed in rather high content (0.10-2.02mg/100g of seeds) in the feed for birds, especially bracts (82.3-441mg/100g). When the suspension prepared from the benzene washing solution of cannabis seeds, BenW, was administered at a dose of 3mg/kg corresponding to △^9-THC into a mouse, i.v., BenW caused hypothermia, catalepsy, pentobarbital-induced sleep prolongation and suppression of locomotor activity. These pharmacological activities of BenW were significantly higher than those of △^9-THC (3mg/kg, i.v.). These results may indicate the necessity to reconsider the present regulations on marihuana.
1 0 0 0 OA 糖尿病薬物療法模擬体験学習の教育効果
- 著者
- 菊池 千草 堀 英生 前田 徹 松永 民秀 鈴木 匡
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.131, no.3, pp.477-483, 2011-03-01 (Released:2011-03-01)
- 参考文献数
- 10
- 被引用文献数
- 2 3
One of the Specific Behavioral Objectives (SBOs) of pharmaceutical education model-core curriculum is as follows: “Understand patient's state of mind and be sensitive to patient's feelings”. We performed learning through simulation of diabetes drug therapy as a means to achieve the objective and evaluated the educational effects of the learning. The simulation was performed and a questionnaire survey was conducted among the 4th-year students of the 6-year curriculum before and after simulation. The score of “level of understanding patient's feelings” was significantly increased after simulation (p<0.001). In addition, the score tended to be associated (R2=0.192) with an increased score in two factors that affect patients' self-care action: “Consciousness of diabetes mellitus” (β=0.251, p=0.062) and “Time and effort for drug therapy” (β=0.248, p=0.065). The main topics of discussion about the simulation included “Lack of sense of critical illness”, “Lifestyle”, “Dose regimen” and “Necessity of support from patients' family and others close to them”. Therefore, the learning through simulation diabetes drug therapy was effective to understand patients' states of mind because students learned the importance of some factors affecting self-care action.
1 0 0 0 OA 実務実習事前学習における服薬並びに患者指導の模擬体験教育プログラムの効果
- 著者
- 菊池 千草 松永 民秀 鈴木 匡
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.135, no.6, pp.809-820, 2015-06-01 (Released:2015-06-01)
- 参考文献数
- 13
- 被引用文献数
- 2 3
Pharmacy school students were trained in a program simulating medication administration and giving adherence instructions. Following the training, the educational effects were evaluated. Students were separated into two groups. One group of students played the role of pharmacists and instructed simulated patients on medication adherence. Another group of students played the role of patients receiving simulated drug therapy; they were instructed on medication adherence by the students playing the role of pharmacists. The educational effects were evaluated using a questionnaire. The scores for “recognition of factors that influence medication adherence” tended to increase after the simulation, and they increased significantly after practical training. The scores for “self-evaluation of technique for instructing patients on medication adherence” increased significantly after the simulation, and they increased even more after practical training. The students' understanding of the effects on patients who were being instructed also increased significantly after the simulation, and these changes were maintained after practical training. In particular, students became more aware of the influence of pharmacists' attitudes. In practical training, the simulation training was helpful for bedside practice at hospital pharmacies and over-the-counter service at community pharmacies. Thus, the use of role play and simulated patients was an effective method for training pharmacy students to instruct patients on medication adherence.