著者
永井 栄一
出版者
保健医療学学会
雑誌
保健医療学雑誌 (ISSN:21850399)
巻号頁・発行日
vol.12, no.1, pp.75-82, 2021-04-01 (Released:2021-04-01)
参考文献数
50

要旨 握力測定において,その測定法と測定条件は測定値に影響を与える.握力測定において測定方法と測定条件が,握力へどのような影響を与えるのか,文献レビューを通して概括する.握力測定における測定方法と測定条件が,測定値に与える影響が明らかになれば,信頼性・妥当性の高い測定が可能となり,評価や治療効果の判定を正確に行うことが可能となる.
著者
佐藤 哲男 細川 正清 渥美 亮 鈴木 亘 伯水 英夫 永井 栄一
出版者
The Pharmaceutical Society of Japan
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.17, no.5, pp.662-664, 1994-05-15 (Released:2008-04-10)
参考文献数
18
被引用文献数
79 135

We measured the plasma concentrations of 7-ethyl-10-[4-(1-piperidino)-1-piperidine] carbonyloxycamptothecin (CPT-11) and the active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), after treatment with CPT-11 to rats pretreated with bis-p-nitrophenylphosphate (BNPP) which is a specific inhibitor of carboxylesterase, and non-pretreated rats. The plasma level of SN-38 was decreased in the BNPP-pretreated group compared with these of non-pretreated group, indicating that the esterase involved in CPT-11 metabolism is a carboxylesterase. We also characterized the molecular species of carboxylesterase involved in CPT-11 metabolism using enzyme preparations purified from liver microsomes. Thirteen carboxylesterase isozyme activities towards CPT-11 were compared and guinea pig GLP1 was found to have the highest activity, while human HU1 isozyme had relatively lower activity than those of animal species. In studies on the kinetic parameters of the hydrolysis of CPT-11 by the purified carboxylesterase isozymes the highest Vmax value of the isozymes was found in human HU1 and the smallest was seen in rat RL1. The Vmax/Km for RL1 showed the largest value of 21.7 nmol/mg protein/mM.