著者

河野 南雄 佐々木 則子 棚橋 豊子 村岡 祝子 東 ちえ子

出版者

社団法人 日本泌尿器科学会

雑誌

日本泌尿器科学会雑誌 (ISSN:00215287)

巻号頁・発行日

vol.66, no.11, pp.742-752, 1975

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There are many reports on the relationship among malignant tumors, blood clotting and fibrinolytic enzyme system. The present report describes the fibrinolytic enzyme system in plasma of rats with experimental urinary bladder tumor. The plasma was separated into three fractions with lysinesepharose affinity chromatography. The materials were Wistar-Imamichi strain male rats which had been administered a dose of 0.02mg/head/day of N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) from 8 weeks old to 16 weeks old and then sacrified at 28 weeks old. Fraction-I did not contain either plasmin (PL) or plasminogen activator (PLg-act). Though the normal rat plasma sometimes has a slight antiplasmic action, the plasma of rats which had been administered BBN had a marked antiplasmic action. However, the action did not correspond with bladder tumor and hyperplasia. The rat plasma had an antiurokinase activity irrespective of BBN-administration. Sometimes fraction-II had also PLg-act irrespective of BBN-administration. On the rats which had been administered BBN, the activity of PLg-act in the bladder tumor-group and in the hyperplasia-group had an increasing tendency which was more marked than that in the unchanged group. Fraction-III revealed mainly the PL-activity. Normal rats had no activated PL, but the animals administered BBN revealed PL-activity. The PL-activity in the unchanged group had a more marked increasing tendency that in the bladder tumor group and hyperplasia group.

著者

河野 南雄 佐々木 則子 溝上 隆

出版者

Japanese Society of Nephrology

雑誌

日本腎臓学会誌 (ISSN:03852385)

巻号頁・発行日

vol.17, no.3, pp.171-189, 1975

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Small bodies with suspicion of a platelet by its size and appearance with granules contained were found in the human urine. In this study, a comparison has been made between the small body and normal platelets in the blood and also between platelets suspended in normal urine supernatant by the Giemsa staining method, the phase microscopy and the scanning electron microscopy. By Giemsa staining and the phase microscopy, the small bodies and platelets suspended in urine supernatant were showed similar to that in blood. Through scanning electron microscope, the majority of platelets suspended in urine were spherical form with smooth surface, or dendritic form with pitted and irregular surface similar to that in blood, but some remained as discs which were swelling than that in blood. Moreover the surface of these various platelets in urine were like that of platelets in blood. The small bodies in urine were similar to platelets suspended in urine. Although further investigations are required, we would like to consider that these small bodies are platelets and platelets could be found in urine.

著者

河野 南雄

出版者

東京女子医科大学学会

雑誌

東京女子医科大学雑誌 (ISSN:00409022)

巻号頁・発行日

vol.41, no.12, pp.939-939, 1971-12-25

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東京女子医科大学学会第171回例会 昭和46年10月22日 東京女子医科大学本部講堂

著者

河野 南雄 橋本 達也 置塩 則彦 藤原 達司 村岡 祝子 溝上 隆

出版者

社団法人日本泌尿器科学会

雑誌

日本泌尿器科學會雜誌 (ISSN:00215287)

巻号頁・発行日

vol.67, no.9, 1976-09-20

著者

河野 南雄 佐々木 則子 棚橋 豊子 村岡 祝子 東 ちえ子

出版者

社団法人日本泌尿器科学会

雑誌

日本泌尿器科學會雜誌 (ISSN:00215287)

巻号頁・発行日

vol.66, no.11, pp.742-752, 1975-11-20

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There are many reports on the relationship among malignant tumors, blood clotting and fibrinolytic enzyme system. The present report describes the fibrinolytic enzyme system in plasma of rats with experimental urinary bladder tumor. The plasma was separated into three fractions with lysine-sepharose affinity chromatography. The materials were Wistar-Imamichi strain male rats which had been administered a dose of 0.02 mg/head/day of N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) from 8 weeks old to 16 weeks old and then sacrified at 28 weeks old. Fraction-I did not contain either plasmin (PL) or plasminogen activator (PLg-act). Though the normal rat plasma sometimes has a slight antiplasmic action, the plasma of rats which had been administered BBN had a marked antiplasmic action. However, the action did not correspond with bladder tumor and hyperplasia. The rat plasma had an antiurokinase activity irrespective of BBN-administration. Sometimes fraction-II had also PLg-act irrespective of BBN-administration. On the rats which had been administered BBN, the activity of PLg-act in the bladder tumor-group and in the hyperplasia-group had an increasing tendency which was more marked than that in the unchanged group. Fraction-III revealed mainly the PL-activity. Normal rats had no activated PL, but the animals administered BBN revealed PL-activity. The PL-activity in the unchanged group had a more marked increasing tendency that in the bladder tumor group and hyperplasia group.