1 0 0 0 OA 皮膚筋炎に併発する急速進行性間質性肺炎の病態解明と新規治療法開発の試み
皮膚筋炎(Dermatomyositis: DM)に見出された抗CADM-140/MDA5抗体(抗MDA-5抗体)は,治療抵抗性で予後不良の急速進行性間質性肺炎(rapidly progressive interstitial lung disease: RP-ILD)と密接に関連することがあきらかになっている.本研究での同病態における各種サイトカインレベルの検討でIL-6がより重要な役割を果たしている可能性が示唆された.また,臨床的には抗MDA5抗体価がRP-ILDを併発したDMの短期的な予後予測や長期的な再発予測に有用である可能性が示唆された.
- 著者
- 河野 南雄 佐々木 則子 棚橋 豊子 村岡 祝子 東 ちえ子
- 出版者
- 社団法人 日本泌尿器科学会
- 雑誌
- 日本泌尿器科学会雑誌 (ISSN:00215287)
- 巻号頁・発行日
- vol.66, no.11, pp.742-752, 1975
There are many reports on the relationship among malignant tumors, blood clotting and fibrinolytic enzyme system. The present report describes the fibrinolytic enzyme system in plasma of rats with experimental urinary bladder tumor. The plasma was separated into three fractions with lysinesepharose affinity chromatography. The materials were Wistar-Imamichi strain male rats which had been administered a dose of 0.02mg/head/day of N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) from 8 weeks old to 16 weeks old and then sacrified at 28 weeks old. Fraction-I did not contain either plasmin (PL) or plasminogen activator (PLg-act). Though the normal rat plasma sometimes has a slight antiplasmic action, the plasma of rats which had been administered BBN had a marked antiplasmic action. However, the action did not correspond with bladder tumor and hyperplasia. The rat plasma had an antiurokinase activity irrespective of BBN-administration. Sometimes fraction-II had also PLg-act irrespective of BBN-administration. On the rats which had been administered BBN, the activity of PLg-act in the bladder tumor-group and in the hyperplasia-group had an increasing tendency which was more marked than that in the unchanged group. Fraction-III revealed mainly the PL-activity. Normal rats had no activated PL, but the animals administered BBN revealed PL-activity. The PL-activity in the unchanged group had a more marked increasing tendency that in the bladder tumor group and hyperplasia group.
1 0 0 0 尿中血小板(予報)
- 著者
- 河野 南雄 佐々木 則子 溝上 隆
- 出版者
- Japanese Society of Nephrology
- 雑誌
- 日本腎臓学会誌 (ISSN:03852385)
- 巻号頁・発行日
- vol.17, no.3, pp.171-189, 1975
Small bodies with suspicion of a platelet by its size and appearance with granules contained were found in the human urine. In this study, a comparison has been made between the small body and normal platelets in the blood and also between platelets suspended in normal urine supernatant by the Giemsa staining method, the phase microscopy and the scanning electron microscopy. By Giemsa staining and the phase microscopy, the small bodies and platelets suspended in urine supernatant were showed similar to that in blood. Through scanning electron microscope, the majority of platelets suspended in urine were spherical form with smooth surface, or dendritic form with pitted and irregular surface similar to that in blood, but some remained as discs which were swelling than that in blood. Moreover the surface of these various platelets in urine were like that of platelets in blood. The small bodies in urine were similar to platelets suspended in urine. Although further investigations are required, we would like to consider that these small bodies are platelets and platelets could be found in urine.
- 著者
- 河野 南雄 佐々木 則子 棚橋 豊子 村岡 祝子 東 ちえ子
- 出版者
- 社団法人日本泌尿器科学会
- 雑誌
- 日本泌尿器科學會雜誌 (ISSN:00215287)
- 巻号頁・発行日
- vol.66, no.11, pp.742-752, 1975-11-20
There are many reports on the relationship among malignant tumors, blood clotting and fibrinolytic enzyme system. The present report describes the fibrinolytic enzyme system in plasma of rats with experimental urinary bladder tumor. The plasma was separated into three fractions with lysine-sepharose affinity chromatography. The materials were Wistar-Imamichi strain male rats which had been administered a dose of 0.02 mg/head/day of N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) from 8 weeks old to 16 weeks old and then sacrified at 28 weeks old. Fraction-I did not contain either plasmin (PL) or plasminogen activator (PLg-act). Though the normal rat plasma sometimes has a slight antiplasmic action, the plasma of rats which had been administered BBN had a marked antiplasmic action. However, the action did not correspond with bladder tumor and hyperplasia. The rat plasma had an antiurokinase activity irrespective of BBN-administration. Sometimes fraction-II had also PLg-act irrespective of BBN-administration. On the rats which had been administered BBN, the activity of PLg-act in the bladder tumor-group and in the hyperplasia-group had an increasing tendency which was more marked than that in the unchanged group. Fraction-III revealed mainly the PL-activity. Normal rats had no activated PL, but the animals administered BBN revealed PL-activity. The PL-activity in the unchanged group had a more marked increasing tendency that in the bladder tumor group and hyperplasia group.