著者

清水 利彦 柴田 護 鈴木 則宏

出版者

日本神経学会

雑誌

臨床神経学 (ISSN:0009918X)

巻号頁・発行日

vol.51, no.2, pp.103-109, 2011 (Released:2011-02-17)

参考文献数

43

被引用文献数

4 4

---

Cortical spreading depressionは片頭痛の前兆への関与に加え三叉神経血管系を活性化させ頭痛発生のtriggerとなる可能性が示されている.脳硬膜および三叉神経節にはcalcitonin gene-related peptide(CGRP)に加え,侵害刺激受容体transient receptor potential cation channel, subfamily V, member 1(TRPV1)の存在が明らかにされ片頭痛の病態への関与が考えられている.本稿では片頭痛における基礎研究の進歩およびCGRP受容体アンタゴニストをふくむ最近の治療について概説する.

著者

清水 利彦

出版者

日本神経治療学会

雑誌

神経治療学 (ISSN:09168443)

巻号頁・発行日

vol.35, no.3, pp.295-297, 2018 (Released:2018-12-25)

参考文献数

15

---

Migraine is a most common neurological disease that affects nearly 10% of the general population. However, the pathophysiology of migraine is obscure. Previously, it was believed that the pathophysiology of migraine could be explained entirely by the vascular theory, which is that all symptoms including aura of migraine and headache are caused by abnormal vascular responses. However, many subsequent researches have revealed that it is not possible to explain the symptoms of migraine only by abnormal vascular responses. Instead, functional abnormalities of the neuronal activities observed in the cortical spreading depression are thought to be also involved in the pathophysiology of migraine. Furthermore, it is reported the changes of functional connectivity in cerebral pain matrix system and functional abnormality of descending pain inhibitory system in migraine patients. In addition, it is also believed that the sensitization of the trigeminovascular neurons play an important roles in migraine pathophysiology. The present review discusses the recent findings of migraine pathophysiology.

著者

柴田 護 清水 利彦

出版者

慶應義塾大学

雑誌

基盤研究(C)

巻号頁・発行日

2014-04-01

---

マウスのwhisker padに10 mMカプサイシンを30分間作用させてTRPV1刺激を6日間行った。刺激と同側の三叉神経節の切片を作成して電子顕微鏡でミトコンドリアの観察を行った。なお、三叉神経節採取のタイミングは2, 4, 6日間投与完了の24時間後とした。2日投与では特に形態異常は認めなかったが、4日投与では主として小型の三叉神経ニューロンで内部構造の破壊を呈したミトコンドリアが確認された。しかし、6日間投与後にはニューロン内のミトコンドリア形態はほぼ正常であった。以上のことから、何らかの修復機構が作動するものと考えられた。細胞実験からミトファジーの機能が重要であることがわかった。

著者

森田 陽子 福内 靖男 厚東 篤生 鈴木 則宏 五十棲 一男 後藤 淳 清水 利彦 高尾 昌樹 青山 正洋

出版者

The Keio Journal of Medicine

雑誌

The Keio Journal of Medicine (ISSN:00229717)

巻号頁・発行日

vol.46, no.3, pp.120-127, 1997 (Released:2009-03-27)

参考文献数

25

被引用文献数

10 15

---

We investigated rapid changes in pial arterial diameter and in cerebral blood flow (CBF) caused by transient ipsilateral common carotid artery occlusion (CCA-O) in anesthetized rats in order to elucidate how the cerebral circulation reacts to acute stem artery occlusion. In separate groups of rats, pial arterial diameter was recorded through a dosed cranial window and CBF was recorded by laser-Doppler flowmetry. CCA-O was performed for 5 minutes under normotension and normocapnia (control) and under graded hypotension, hypercapnia and hypocapnia. In the control condition, pial arterial diameter increased rapidly, triggered by CCA-O. It took 12±3 s to reach the maximum of 204±42% of the value before CCA-O, and 60±24 s to become stable at 131±11%. CBF decreased rapidly to 66±11%, then increased reactively to 135±9%, and again decreased to 91±3%. The reactive increase in CBF caused by CCA-O decreased in parallel with the degree of hypotension, and also became barely detectable under hypercapnia. Our data suggest that active vascular dilation in the territory of the occluded artery is important for inducing collateral circulation.

著者

清水 利彦

出版者

日本神経治療学会

雑誌

神経治療学 (ISSN:09168443)

巻号頁・発行日

vol.36, no.3, pp.238-240, 2019 (Released:2019-11-25)

参考文献数

17

---

Trigeminal autonomic cephalalgias includes cluster headache, paroxysmal hemicrania, short–lasting unilateral neuralgiform headache attacks and hemicrania continua. The trigeminal autonomic cephalalgias share the clinical features of unilateral headache and, usually, prominent cranial parasympathetic autonomic features, which are lateralized and ipsilateral to the headache. However, the responses to the treatment for the headaches are different in each trigeminal autonomic cephalalgias. The present review will discuss the recent findings of the treatments for the trigeminal autonomic cephalalgias.