著者
中尾 俊一 森田 十誉子 安井 利一 田中 園治 小野沢 裕彦 田中 入 大高 義文 菅沼 信夫 徳光 史彦 山本 瑞哉
出版者
一般社団法人 口腔衛生学会
雑誌
口腔衛生学会雑誌 (ISSN:00232831)
巻号頁・発行日
vol.41, no.5, pp.643-653, 1991
被引用文献数
6 4

The purpose of this study was to investigate the clinical effect of dentifrice R containing 0.05% tranexamic acid and 0.05% dipotassium glycyrrhizinate on the improvement of periodontal disease compared with dentifrice T containing 0.05% tranexamic acid.<BR>Subjects were 148 adults who had no serious oral or systemic diseases. They were divided into two groups equally and performed toothbrushing twice a day for four weeks with dentifrice R or T.<BR>The PMA index, redness, swelling, and plaque score were selected as indices for clinical evaluation of periodontal condition.<BR>The results obtained were as follows.<BR>1) Dentifrice R was significantly superior to dentifrice T in the improvement of PMA index (p<0.01), redness (p<0.01) and swelling (p<0.05). There was no significant difference in the improvement of plaque score between dentifrices R and T.<BR>2) The mean improvement rates of dentifrice R and dentifrice T were 37.0% and 26.3% in PMA index, 40.7% and 25.2% in redness, and 36.7% and 29.9% in swelling, respectively.<BR>3) No particular side effects were observed during this clinical study.