著者

池田 克巳 引間 徹 楠 公仁 渡辺 幸男 藤橋 弘 日吉 貴一郎 菅沼 信夫 岩崎 浩一郎

出版者

特定非営利活動法人 日本歯周病学会

雑誌

日本歯周病学会会誌 (ISSN:03850110)

巻号頁・発行日

vol.23, no.3, pp.437-450, 1981-09-28 (Released:2010-07-16)

参考文献数

32

被引用文献数

3 3

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In order to prevent the periodontal disease, it would be a matter of important fact to apply cleaning the teeth and giving massage on marginal gingiva by means of brushing and using dentifrices including effective ingredients.The aim of this study was to investigate on the effects of the dentifrice including tranexamic acid (T dentifrice) comparing with placebo (P dentifrice).Subjects were 242 students of Josai Dental University who had no serious oral disease.P-M-A index, redness, bleeding and dental plaque were selected as indices for clinical evaluation of periodontal disease. This study was conducted with double blind method.The results obtained were as follows:1) Subjects used for statistical analysis were 207 students. (104: T dentifrice group, 103: P dentifrice group).2) T dentifrice was significantly more superior in recovery of P-M-A index (p<0.01), redness (p<0.01) and bleeding (p<0.05). On the other hand, there was no significant difference in recovery of dental plaque between T dentifrice and P dentifrice.3) The mean reduction rates of T dentifrice and P dentifrice were 31.0% and 14.3% in P-M-A index, 36.3% and 19.6% in redness, 66.7% and 42.9% in bleeding, respectively.4) Significant difference was observed in the general improvement (p<0.01). The rates of the general improvement of T dentifrice and P dentifrice were 71.0% and 48.5%, respectively.5) No particular side effect was observed through this study.

著者

中尾 俊一 森田 十誉子 安井 利一 田中 園治 小野沢 裕彦 田中 入 大高 義文 菅沼 信夫 徳光 史彦 山本 瑞哉

出版者

一般社団法人 口腔衛生学会

雑誌

口腔衛生学会雑誌 (ISSN:00232831)

巻号頁・発行日

vol.41, no.5, pp.643-653, 1991

被引用文献数

6 4

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The purpose of this study was to investigate the clinical effect of dentifrice R containing 0.05% tranexamic acid and 0.05% dipotassium glycyrrhizinate on the improvement of periodontal disease compared with dentifrice T containing 0.05% tranexamic acid.<BR>Subjects were 148 adults who had no serious oral or systemic diseases. They were divided into two groups equally and performed toothbrushing twice a day for four weeks with dentifrice R or T.<BR>The PMA index, redness, swelling, and plaque score were selected as indices for clinical evaluation of periodontal condition.<BR>The results obtained were as follows.<BR>1) Dentifrice R was significantly superior to dentifrice T in the improvement of PMA index (p<0.01), redness (p<0.01) and swelling (p<0.05). There was no significant difference in the improvement of plaque score between dentifrices R and T.<BR>2) The mean improvement rates of dentifrice R and dentifrice T were 37.0% and 26.3% in PMA index, 40.7% and 25.2% in redness, and 36.7% and 29.9% in swelling, respectively.<BR>3) No particular side effects were observed during this clinical study.