- 著者
- 藤原 由紀子 町田 治彦 田中 功 福井 利佳 平林 望 白石 くみ子 岸田 弘美 森 恵美子 増川 愛 上野 惠子
- 出版者
- 公益財団法人 日本心臓財団
- 雑誌
- 心臓 (ISSN:05864488)
- 巻号頁・発行日
- vol.42, no.9, pp.1166-1172, 2010 (Released:2012-04-21)
- 参考文献数
- 10
背景および目的: 64列multidetector-row CT(MDCT) 心臓検査は, 非侵襲的に冠動脈の詳細な形態評価が可能であるが, 放射線被曝による発癌リスクの増加が問題視されている. これに対し, 被曝低減技術の活用と画質劣化の回避のため, しばしば, β遮断薬経口投与による心拍数の低減が図られる. 今回, われわれは, 本検査の安全性の評価と合理的なワークフロー確立のため, β遮断薬投与後の心拍数の経時的変化と検査前後の血圧変動について検討した.方法: 対象は, β遮断薬経口投与下に64列MDCT心臓検査前を施行した連続551例. 投与前, 投与後15~90分, 撮影直前の心拍数と投与前と撮影直後の血圧を測定し, 投与前心拍数に応じた最低心拍数到達時間, 心拍数, および血圧低減率, ならびに心拍数40bpm以下の高度徐脈, 急激な血圧低下に伴うショックなどの重篤合併症の出現頻度を検討した.結果: β遮断薬投与後, 心拍数は経時的に低下し, 最低心拍数到達時間は, 投与前心拍数80bpm未満で60分, 80~89bpmで75分, 90bpm以上で90分であり, 心拍数低減率(最低心拍数)は, 投与前心拍数70bpm未満で16.4%(54.9bpm) , 70~79bpmで20.3%(58.2bpm), 80~89bpmで24.4%(62.9bpm), 90bpm以上で27.7%(69.5bpm)であった. 血圧低減率は, 収縮期血圧において, 80bpm未満で4.3%, 80~89bpmで5.0%, 90bpm以上で4.8%, 拡張期血圧においては70bpm未満で0.7%, 70~79bpmで1.5%, 80~89bpmで1.0%, 90bpm以上で2.8%であった. また, 本剤投与による重篤な合併症はなかった.結論: β遮断薬経口投与下MDCT心臓検査は安全に遂行可能であった. また, 投与前心拍数に応じた心拍数の経時的低減効果が判明し, 検査の流れの予測が可能となった. 今後, これらを踏まえ患者の不安の軽減や待機時間の短縮などに生かしていきたい.
1 0 0 0 OA トモシンセシスの臨床応用
- 著者
- 町田 治彦
- 出版者
- 医用画像情報学会
- 雑誌
- 医用画像情報学会雑誌 (ISSN:09101543)
- 巻号頁・発行日
- vol.30, no.4, pp.76-82, 2013 (Released:2013-12-25)
- 参考文献数
- 30
With flat panel detector radiography or x-ray TV systems, digital tomosynthesis (DT) has been recently introduced as limited-angle CT, which can remove overlying structures, enhance local tissue separation, and provide depth information about structures of interest by providing tomographic images of high quality. DT is advantageous in various clinical applications, including chest, head and neck, orthopedic, fluoroscopic, and mammographic studies. Specifically, compared to conventional radiography or fluoroscopy, DT can improve the detection of pulmonary nodules, the diagnosis of paranasal sinusitis, and the delineation of subtle fractures, particularly in complex anatomic structures, and gastrointestinal and breast tumors by less tissue overlap. Compared to CT, DT can reduce radiation exposure by limited sweep angle and improve the assessment of fine bony changes by better in-plane resolution and the postoperative evaluation in patients with metallic prostheses and osteosynthesis materials by less metallic artifact. DT is also useful for functional, weight-bearing and stress tests by more arbitrary patient positioning. To accomplish adequate patient management, a comprehensive understanding of the clinical utilities and limitations of those DT applications is important for the improvement of diagnostic quality, workflow, and cost-effectiveness.
- 著者
- 実吉 峯郎 両角 正海 小玉 健次郎 町田 治彦 国中 明 吉野 宏
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.28, no.10, pp.2915-2923, 1980-10-25 (Released:2008-03-31)
- 参考文献数
- 24
- 被引用文献数
- 16 26
Enzymatic selective dephosphorylation of 1-β-D-arabinofuranosylcytosine 3', 5'-diphosphate (1) with nuclease-3'-nucleotidase P1 at 60° for 24 hr gave 1-β-D-arabinofuranosylcytosine 5'-phosphate (Ara CMP) (2) in good yield. The acylation of both N4- and the 2', 3'-hydroxyl groups of 2 followed by coupling with various alcohols and phenols in the presence of 2, 4, 6-triisopropylbenzenesulfonyl chloride and subsequent alkaline hydrolysis afforded the title compounds (4). The resulting 32 kinds of Ara CMP alkyl or aryl esters were examined to determine their biological activities, such as antiviral activity against herpes simplex type 1 in cultured human embryonic lung fibroblast cells, growth inhibitory activity against mouse leukemic L5178Y cells in culture and antileukemic activity against L-1210 in mice. Ara CMP esters were active in these assay systems.
- 著者
- 松田 彰 篠崎 操 宮坂 貞 町田 治彦 畔蒜 藤一
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.33, no.4, pp.1766-1769, 1985-04-25 (Released:2008-03-31)
- 参考文献数
- 24
- 被引用文献数
- 19 30
Reaction of 2-iodoadenosine (2) with terminal alkynes in the presence of bis (triphenylphosphine) palladium dichloride and cuprous iodide in triethylamine and N, N, -dimethylformamide gave 2-alkynyl-adenosines (3a-h) in excellent yields. Several compounds showed high activity as inhibitors in rat passive cutaneous anaphylaxis (PCA) reaction. Among them, 2-(3-hydroxypropynyl)- and 2-(3-hydroxybutynyl)-adenosines (3d, f) are much more potent than disodium cromoglycate (DSCG).