- 著者
- 若杉 隆志
- 出版者
- 教育史料出版会
- 雑誌
- みんなの図書館 (ISSN:03860914)
- 巻号頁・発行日
- no.429, pp.17-20, 2013-01
1 0 0 0 OA トログリタゾンの代謝と肝細胞障害性の検討
- 著者
- 横井 毅 山本 優衣 柴田 文佳 鈴木 美紀恵 島田 典招 若杉 隆伸 山木 光男 山守 育雄 中島 美紀 山崎 浩史
- 出版者
- The Japanese Society for the Study of Xenobiotics
- 雑誌
- 薬物動態 (ISSN:09161139)
- 巻号頁・発行日
- vol.15, no.supplement, pp.126-127, 2000 (Released:2007-03-29)
- 参考文献数
- 3
Troglitazone, a new oral antidiabetic drug, has been reported to cause idiosyncratic hapatitis in certain individuals. The mechanism for hepatic failure was investigated with comparison between troglitazone and its metabolites and other thiazolidinedions. Oxidation pathway of troglitazone to a qunone-type metabolite was catalyzed mainly by CYP2C8 and CYP3A4 in human liver microsomes. Inhibitory effects of troglitazone and its metabolites on drug oxidation activities of human CYPs were not potent. Autoimmune antigen was identified in patients with idiosyncratic hepatitis. Hepatic toxicity did not appear in troglitazone treated rats after modifications of sulfotransferase, gluclonosyl-trasferase, or glutathione S-transferase activities. Treatment of HepG2 cell lines with troglitazone and a quinone type-metabolite showed time- and concentration-dependent cytotoxicity. Troglitazone induced apoptotic cell death in HepG2 cells. Taking these results into consideration, the causal factor(s) for idiosyncratic hepatitis in human remained unclear.
1 0 0 0 OA トログリタゾンの代謝と肝細胞障害性の検討
- 著者
- 横井 毅 山本 優衣 柴田 文佳 鈴木 美紀恵 島田 典招 山木 光男 若杉 隆伸 山守 育雄 中島 美紀 山崎 浩史
- 出版者
- The Japanese Society for the Study of Xenobiotics
- 雑誌
- 薬物動態 (ISSN:09161139)
- 巻号頁・発行日
- vol.16, no.2, pp.145-150, 2001 (Released:2007-03-29)
- 参考文献数
- 9
- 被引用文献数
- 1
Troglitazone, a new oral antidiabetic drug, has been reported to cause idiosyncratic hepatitis in certain individuals. The mechanism for the hepatic failure was investigated with comparison between troglitazone and its metabolites and other thiazolidinediones, pioglitazone and rosiglitazone. Hepatic toxicity did not appear in rats in troglitazone-administered study after modifications of sulfotransferase and glucuronosyltrasferase activities and glutathione concentration. Oxidation pathway of troglitazone to a quinine-type metabolite was catalyzed mainly by CYP2C8 and CYP3A4 in human liver microsomes. Inhibitory effects of troglitazone and its metabolites on drug oxidation activities of human P450s would not be potent, based on its low blood concentrations and high protein binding ratio. An autoimmune antibody against aldolase B was identified in two patients with troglitazone-induced idiosyncratic hepatitis. However, this antibody was also detected in some other hepatic diseases, in spite of no cases in health control subjects. Treatment of HepG2 cell lines with troglitazone and a quinone type-metabolite showed time and concentration-dependent cytotoxicity. Troglitazone induced apoptotic cell death in HepG2 cells characterized by internucleosomal DNA fragmentation and nuclear condensation. Taking these results into consideration, the causal factor (s) for idiosyncratic hepatitis in human remained unclear.
1 0 0 0 OA 企業の国際化と市場特性に関する理論的・実証的研究
この研究は、貿易・直接投資の自由化が貿易・直接投資の拡大・企業の技術水準や生産性の向上に与える影響、地域貿易協定の締結が域外国のアンチダンピング(AD)政策に与える影響等を理論面から明らかにしている。また日中のミクロデータを用いた実証研究によって、中国市場における制度的変化(WTO加盟に伴う市場開放、国有企業改革、知的財産権の保護の強化)が中国企業の輸出・研究開発・イノベーション、日本の労働市場や企業の雇用の変化に与える影響を明らかにしている。さらにTask content(業務)の輸出入の変化によって日本の貿易構造の変化を明らかにしている。
1 0 0 0 糖尿病患者における動脈壁組織中のLp(a)
- 著者
- 中谷 利雄 脇田 崇弘 大田 陸夫 田中 勝久 若杉 隆
- 出版者
- 公益社団法人日本セラミックス協会
- 雑誌
- 日本セラミックス協会学術論文誌 : Nippon Seramikkusu Kyokai gakujutsu ronbunshi (ISSN:18821022)
- 巻号頁・発行日
- vol.111, no.1290, pp.137-141, 2003-02-01
- 被引用文献数
- 8
Powders in the CeO_2-ZrO_2-MO_x system were prepared by coprecipitation method. Influence of adding a third components MO_x of transition metal oxides and rare earth metal oxides on the specific surface area (SA) and oxygen storage capacity (OSC) were investigated. It was found that transition metal oxides decrease drastically both SA and OSC values at 1000℃. On the other hand, rare earth metal oxides slightly decreased OSC values. The OSC values of the 20CeO_2- (80-y) ZrO_2-yMO_x powders with y=0-20 mol% LaO_1.5, showed a maximum at around 6 mol% LaO_1.5. In the CeO_2-ZrO_2-MO_x system, 20CeO_2・74ZrO_2・6LaO_1.5 (mol%) powders exhibited the most efficient performance with a high thermal stability up to 1000℃.