著者
衛藤 光
出版者
公益社団法人 日本皮膚科学会
雑誌
日本皮膚科学会雑誌 (ISSN:0021499X)
巻号頁・発行日
vol.122, no.3, pp.599-605, 2012-03-20 (Released:2014-11-13)

爪に現れる変化には皮膚疾患による限局性のものと,全身性疾患による多くの爪に生じるものがある.代表的な全身性疾患による爪の変化には,爪甲剥離症;甲状腺機能亢進症,白い爪;腎障害・肝障害・炎症性腸炎,黄色い爪;気管支拡張症,黒い爪・爪甲色素線条;アジソン病・抗がん剤,赤い爪;先天性心疾患・多血症・薬剤性,匙状爪;貧血,ヒポクラテスの爪;肺癌・炎症性腸炎・HIV感染症,爪甲萎縮症;扁平苔癬・アミロイドーシス,爪囲紅斑・爪上皮延長・爪上皮出血点;膠原病,爪甲脆弱化を伴う爪囲炎;分子標的薬(EGFRI)がある(表).
著者
二塚 信 衛藤 光明 内野 誠
出版者
一般社団法人日本衛生学会
雑誌
日本衛生学雑誌 (ISSN:00215082)
巻号頁・発行日
vol.78, pp.23002, 2023 (Released:2023-07-14)
参考文献数
21

Even today, more than 60 years after the discovery of Minamata disease, many controversies continue to arise from various viewpoints. Recently, Dr. Shigeru Takaoka has published a book entitled “Minamata Disease and the Responsibility of Medical authorities” as a summary of his and colleagues’ previous works in which he presented their objections to past academic theories. We, who were also engaged in this research at Kumamoto University, would like to address some substantial viewpoints. Drs. Nishimura and Okamoto clarified why a series of cases that were clearly Minamata disease were found only in the Minamata plant from late 1950 to 1975, even though many acetaldehyde plants have been operating in Japan for many years. Dr. Takaoka ignored this very important issue and we point out the lack of reliability of his data from their health examination of “10,000” people. From the pathology perspective, Dr. Takaoka mis­understood the location and plasticity of neurons. From a clinical viewpoint, he mentioned the poor evidence for the characteristics and courses of the patients’ clinical symptoms.