著者
松原 絵里子 小杉 裕一郎 加納 公子 松本 有右 下平 秀夫 内田 寛 湯浅 宏 金谷 芳雄
出版者
一般社団法人 日本医療薬学会
雑誌
病院薬学 (ISSN:03899098)
巻号頁・発行日
vol.19, no.2, pp.129-135, 1993-03-20 (Released:2011-08-11)
参考文献数
16

Accuracy of dividing weight of 11 drugs (5 powders, 3 fine glanules and 3 glanules) were tested on a automatic pre-packing machine, TOSHO BL-4W. The mean coefficient of variation (C. V.) was 3.9% for 30 subpacks of 1g in theoretical weight and sufficient accuracy of dividing weight was obtained. However, fine lactose, corn starch, and precipitated calcium carbonate showed relatively large C. V. values. The mean C. V. of 3 drugs (Gastropylore, heavy magnesium oxide and Marzulene S) were 3.0 and 5.5% obtained on 0.3 and 0.6g in theoretical weight, respectively, and these mean C.V. were regarded as sufficient. However, on 0.3g in theoretical weight, Gastropylore gave relatively large C. V., 8.5%. Gastropylore also gave relatively large C. V. on total weight of 30 subpacks. Angles of fall were highly correlated to C. V. values. It is suggested that angles of fall are especially useful for predict accuracy of dividing weight on a pre-packing machine.
著者
松永 康志 大田 涼子 坂東 信行 山田 博章 湯浅 宏 金谷 芳雄
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.41, no.4, pp.720-724, 1993-04-15 (Released:2008-03-31)
参考文献数
10
被引用文献数
6 13

(E)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-(4-isopropyl)phenyl]-1-butenyl]phenyl monophosphate (TAT-59) is a new drug for the treatment of breast cancer. Physical and chemical stability of a tablet consisting of TAT-59 powder and a few excipients (Formulated tablet), a tablet consisting of only TAT-59 power (TAT-59 tablet) and TAT-59 powder itself itself was evaluated based on water content, tensile strenght, porosity, the amount of TAT-59 and its hydrolysis product, DP-TAT-59.The water content of Formulated tablet increased with relative humidity (RH), whereas that of TAT-59 tablet and TAT-59 powder scarcely changed. The equilibrium water content of Formulated tablet was much greater than that of the TAT-59 tablet or TAT-59 powder due to adsorbed moisture by the excipients. The tensile strength and porosity of Formulated tablet decreased and increased linearly, respectively, with increasing water content. The degradation rate of TAT-59 decreased in the following order : Formulated tablet>TAT-59 tablet>TAT-59 powder. The relationship between equilibrium water content and degradation rate of the Formulated tablet was determined by the Carstensen equation, in which the interaction order between the durg and water content was 1.9, and the degration of TAT-59 in Formulated tablet was related to water content. Thus, it was found that the degradation of TAT-59 was accelerated by compression and addition of excipients.