2 0 0 0 OA トルラ酵母脂質成分 (第1報)
- 著者
- 鈴木 康男 宇田 裕 奥井 誠一
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.85, no.1, pp.72-76, 1965-01-25 (Released:2010-02-19)
- 参考文献数
- 15
- 被引用文献数
- 3
Lipid component, extracted from dried cells of Torulopsis utilis was examined by means of chromatography. It was found that lipid content in dried cells was 3% and this lipid consisted mainly of phospholipid (84%), which was largely composed of lecithin, phosphatidylethanolamine and lysolecithin, however neutral lipids are formed mainly of free fatty acid, triglyceride and sterol.Analysis of the fatty acid composition of the isolated lipid fractions by gas-liquid chromatography showed that acid neutral lipids and phospholipids contained mainly linoleic acid, oleic acid and palmitic acid, while free fatty acid fraction had a very low content of linoleic acid. The lysolecithin fraction contained considerably larger amounts of linoleic acid than the other lipid fractions.
1 0 0 0 OA 環境中の変異原性物質
- 著者
- 橋本 嘉幸 鈴木 康男
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- 衛生化学 (ISSN:0013273X)
- 巻号頁・発行日
- vol.26, no.6, pp.275-285, 1980-12-31 (Released:2008-05-30)
- 参考文献数
- 90
- 被引用文献数
- 1 1
This article reviews the present status of knowledges with respect to the chemical mutagens in the environment. Literatures on environmental mutagens were surveyed with positive results noted in natural products, food additives, smoking, food contaminants and chemicals resulted from environmental pollutants. Test systems detecting these chemical mutagens are summarized, and the advantage and limitation of its relevant use for the detection method of chemical carcinogens are discussed.
- 著者
- 水柿道直 大山 良治 木村 勝彦 石橋 正兀 大野 曜吉 内間 栄行 永盛 肇 鈴木 康男
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- 衛生学 (ISSN:0013273X)
- 巻号頁・発行日
- vol.34, pp.359-365, 1988
- 被引用文献数
- 2
A gas chromatography/selected ion monitoring (GC/SIM) method for the simultaneous determination of aconitum alkaloids such as aconitine, mesaconitine and hypaconitine has been developed. Aconitum alkaloids were converted to their TMS ether derivatives by treatment with N, O-bis (trimethylsilyl) trifluoroacetamide in pyridine at room temperature. The gas chromatograms of reaction products showed in each case a well-resolved doublet consisting of a major (>70%) and a minor components, when analyzed using a 5%-phenylmethylsilicone cross-linked fused silica capillary column. These alkaloid derivatives gave simplified mass spectra with a base peak at m/z 698 for aconitine, m/z 684 for mesaconitine and m/z 596 for hypaconitine. When GC/SIM of aconitine was carried out under monitoring of the ion at m/z 698,detection limit was 10 picograms with signal-to-noise ratio of greater than 10. Linearity was obtained over a range from at least 10 to 1000pg. Similar results were obtained with another alkaloids. The use of this method for the measurement of aconitum alkaloids in biological fluids is described.
1 0 0 0 OA Tocopheronolactoneの生理活性について(第1報)
- 著者
- 内山 充 鈴木 康男 福沢 健治
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- 藥學雜誌 (ISSN:00316903)
- 巻号頁・発行日
- vol.88, no.6, pp.678-683, 1968-06-25
- 被引用文献数
- 33
Mechanism of antioxidation of tocopheronolactone, isolated as the quinonoid metabolic product of α-tocopherol, was examined. Tocopheronolactone was as effective as α-tocopherol in inhibiting the increase of TBA value during the in vitro incubation of α-tocopherol-deficient mouse liver homogenate, but the production of peroxide from unsaturated fatty acids irradiated with ultraviolet ray was not depressed by the sole addition of tocopheronolactone. Reduced tocopheronolactone depressed TBA value during the irradiation of unsaturated fatty acid with ultraviolet ray and reacted with the stable free radical α, α-diphenyl-β-picrylhydrazyl, but tocopheronolactone was not active. Reduced tocopheronolactone was oxidized to tocopheronolactone by free radical products of heme-catalyzed decomposition of cumene hydroperoxide. Tocopheronloactone in cytoplasm was reduced in 9000×g supernatant fraction but not in mitochondria, so that mitochondrial peroxidation was not inhibited by tocopheronolactone itself. Antioxidativeeffect of tocopheronolactone seems to appear after the biochemical reduction of the tocopheronolactone in vivo, followed by the reaction with free radicals and peroxides.
1 0 0 0 当院における自閉的傾向児に対する診療システム
- 著者
- 金尾 晃 岡崎 好秀 堀 雅彦 鈴木 康男 下野 勉 中村 由貴子 林 昌司 黒田 耕平
- 雑誌
- 障害者歯科 = JOURNAL OF THE JAPANESE SOIETY FOR DISABILITY AND ORAL HEALTH (ISSN:09131663)
- 巻号頁・発行日
- vol.27, no.3, 2006-09-20