著者
松田 保 小河原 緑 平林 直子 関 俊子 横内 正利 村上 元孝 島田 馨 三船 順一郎
出版者
一般社団法人 日本血栓止血学会
雑誌
血液と脈管 (ISSN:03869717)
巻号頁・発行日
vol.9, no.2, pp.208-212, 1978

Recently, growing interests had been devoted largely to disseminated intravascular coagulation (DIC), because of its frequency and clinical importance. It has been known that shock is a frequent complication of DIC, although it has not been elucidated whether shock is a cause of DIC rather than a result. This study was made to clarify relationship between DIC and shock in 699 consecutive autopsied cases, almost all of whom was over age sixty, in Tokyo Metropolitan Geriatric Hospital.<br>The diagnosis of DIC was established when coagulation analysis revealed presence of consumption coagulopathy. Among these cases, 106 had evidences of DIC and 30 had clinical and pathological findings highly suggestive of DIC although the coagulation findings were not specific. Shock was complicated in 38 of the former and 10 of the latter.<br>Eight of these 48 patients with DIC complicated with shock revealed consumption coagulopathy simultaneously with the development of shock. 24 cases had not clea r-cut evidences of DIC immediately after the development of shock in coagulation findings, although they showed marked coagulation abnormalities indicating DIC after the shock developed. 44% of conditions associated with the shock in these patients was gram-negative septicaemia. The other underlying pathologic conditons in these cases consisted of cancer, peptic ulcer, acute myocardial infarction and pneumonia.<br>Onset of shock was observed in 16 cases in whom diagnosis of DIC had been already established by coagulation analysis. 11 cases of these had cancer with metastases, primary organs of which were stomach, colon or biliary tracts. 70% of these patients were febrile.<br>Acute renal failure, purpura, petechiae, melena, coma, epileptic seizure, systemic peripheral gangrene and/or red cell fragmentation in peripheral blood smear were main symptoms in DIC with shock. Four cases, excluding two cases in whom DIC developed following development of acute myocardial infarction, showed ECG findings indicating development of acute myocardial infartion, although myocardial infarction was evident in only one cases by postmortem examination.<br>Presence of fibrin thrombi was confirmed in 36 cases out of the 48 autopsied cases with DIC accompained with shock. Terminal hemorrhagic necrotizing enteropathy was observed in 15 of those cases. Hemorrhage from adrenal was observed in 4 cases.<br>From these results, it is concluded that shock does frequently cause DIC and that shock in gram-negative septicaemia is especially important because of its high incidence to result DIC.
著者
蔵本 築 松下 哲 三船 順一郎 坂井 誠 村上 元孝
出版者
一般社団法人 日本老年医学会
雑誌
日本老年医学会雑誌 (ISSN:03009173)
巻号頁・発行日
vol.14, no.2, pp.115-120, 1977-03-30 (Released:2009-11-24)
参考文献数
12
被引用文献数
1

老年者肺炎12例に於て肺炎と同時または稍遅れて前壁中隔硬塞を思わせる心電図変化を認めた. すなわちV1-V3, V4のQSまたはrの減高, ST上昇, 冠性Tが出現し, 肺炎の軽快と共に異常Qは約一週間, 陰性Tは1カ月以内に正常化し, その後剖検し得た8例にはいずれも前壁中隔硬塞を認めなかった. 臨床所見では狭心痛はなく, 呼吸困難, 咳痰, チアノーゼ, 意識障害等が見られ, 肺炎は2葉以上にわたる広範な病巣を示し, 胸膜癒着または胸水を伴った. 検査所見ではGOTの軽度上昇を4例に認めたにすぎず, BUNの一過性上昇, CRP強陽性, PO2低下と共にヘマトクリットは全例4~9%の著明な上昇を示した.剖検し得た8例では肺気腫を6例, 気管支炎を7例に, 剖検時肺炎を6例に認めた. 陳旧性後壁硬塞及び後壁心外膜下出血を各1例に認めた. 左冠動脈前下行枝の50%以上狭窄を7例に認め, 心筋小胼胝を5例に認めた.急性心筋硬塞様心電図の発現機序として慢性肺疾患によるQRS軸の後方偏位, 肺炎に伴う急性右心負荷, hypoxia, 中等度の冠硬化などの上にヘマトクリット, 血液粘度の上昇等が加わって心筋に広範な一過性虚血性変化を来たすものと考えた.