- 著者
-
山路 昭
藤井 康子
奥田 陽子
青野 真知子
佐藤 健太郎
千葉 幹夫
平岡 栄一
- 出版者
- 一般社団法人 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.4, no.1, pp.7-11, 1978 (Released:2011-08-11)
- 参考文献数
- 7
- 被引用文献数
-
1
1
Photodegradation of vitamin K1 and K2 injections during preservation and in intravenous admixtures was investigated by high-pressure liquid chromatography. When exposed to fluorescent light (500 lux), 50% of commercial product (10mg) of vitamin K1 decomposed in about 15 days, compared with about 10 days for the 50% decomposition of vitamin K2 product. In the intravenous admixtures for drip infusion, the residual rate after sunlight irradiation (2, 000 lux) for 3 hours was 43-63% for K1 and 31-44% for K2. Therefore, intravenous admixtures containing theselight-unstable injections require shading during drip infusion. In Osaka University Hospital, the light-resistant covers of containers for injections are used for this purpose.