著者

山路 昭 藤井 康子 奥田 陽子 青野 真知子 佐藤 健太郎 千葉 幹夫 平岡 栄一

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.4, no.1, pp.7-11, 1978 (Released:2011-08-11)

参考文献数

7

被引用文献数

1 1

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Photodegradation of vitamin K1 and K2 injections during preservation and in intravenous admixtures was investigated by high-pressure liquid chromatography. When exposed to fluorescent light (500 lux), 50% of commercial product (10mg) of vitamin K1 decomposed in about 15 days, compared with about 10 days for the 50% decomposition of vitamin K2 product. In the intravenous admixtures for drip infusion, the residual rate after sunlight irradiation (2, 000 lux) for 3 hours was 43-63% for K1 and 31-44% for K2. Therefore, intravenous admixtures containing theselight-unstable injections require shading during drip infusion. In Osaka University Hospital, the light-resistant covers of containers for injections are used for this purpose.

著者

丸田 栄一 但馬 重俊 廣谷 芳彦 前田 義美 西井 諭司 東 敏夫 山路 昭 紀氏 汎恵 平岡 栄一 三牧 孝至 田川 哲三 藪内 百治

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.11, no.5, pp.398-402, 1985-10-20 (Released:2011-08-11)

参考文献数

15

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Phenytoin (PHT) fine granule, which has the same bioavailability as the tablet, has recently been marketed. We projected a change of PHT dosage form from usual powder to fine granule. In view of the fact that 97% of PHT products prescribed and marketed are available in fine granules, 50% PHT preparations were produced in hospital pharmacy. 5 kinds of preparations using various lactoses as diluents were prepared and tested for their quality. Among them, the preparation from Aleviatin fine granule passing through a 42-mesh sieve and EFC lactose showed the best results in the mixing property and various sense tests. The change to this dosage form and its bioavailability tests were carried out by a cooperation of doctors and pharmacists. Serum PHT levels of all patients, assayed by EMIT method, showed a 20% to 30% increase after the administration of the new preparation (50% PHT fine granule with EFC lactose).