著者

下元 幸夫 山路 昭彦 内田 洋平 大西 健二 上原 謙太郎

出版者

公益社団法人 土木学会

雑誌

海岸工学論文集 (ISSN:09167897)

巻号頁・発行日

vol.53, pp.211-215, 2006-10-10 (Released:2010-06-04)

参考文献数

4

被引用文献数

2 2

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2004年に西日本に相次いで来襲した台風は, 瀬戸内海沿岸各地において広範囲にわたる高潮災害をもたらした. これらの台風のうち, 台風0416号では, 潮位偏差のピーク値が台風の最接近時刻から遅れて出現するケースがみられた. 台風の最接近時刻と潮位偏差のピーク時刻に差がみられる現象は, 波浪と高潮の出現時刻においても同様に時間差が生じる可能性を示唆していると考えられる. 一方, 瀬戸内海において波浪と高潮の同時生起特性について研究された例は少ない. 本研究は, あらゆるコースを想定したモデル台風の数値シミュレーションにより, 瀬戸内海沿岸における高潮・波浪の出現特性および同時生起特性について検討を行った.

著者

山路 昭雄 沼田 茂生 斉藤 鉄夫

出版者

一般社団法人 日本原子力学会

雑誌

日本原子力学会誌 (ISSN:00047120)

巻号頁・発行日

vol.29, no.6, pp.555-563, 1987

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A design method is described for the Fe compensational shield which is located around a straight duct in concrete shield wall against γ radiation to compensate the lowering of shielding efficiency caused by the duct. The method has been applied to the configuration, where the source area is not viewed through the duct from the detector point at the duct exit. The form of the compensational shield was determined depending on the wall thickness, the duct diameter, the incident angle of γ-ray beam to the wall, and the densities of the concrete and Fe. An experiment for the compensational shield was performed in the Dry Shielding Facility at JRR-4. The measured dose rates behind the wall were reduced effectively by the compensational shield, so that the maximum dose rates became only slightly higher than that of the bulk shield wall and the dose rates higher than the maximum dose rate for bulk shield wall were restricted only in the area near the duct exit. The experimental results have been analyzed using a multigroup γ-ray single scattering code G33YSN.

著者

山路 昭雄 宮越 淳一 岩男 義明 壺阪 晃 斉藤 鉄夫 藤井 孝良 奥村 芳弘 鈴置 善郎 河北 孝司

出版者

一般社団法人 日本原子力学会

雑誌

日本原子力学会誌 (ISSN:00047120)

巻号頁・発行日

vol.26, no.2, pp.139-156, 1984

被引用文献数

2

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Procedures of shielding analysis are described which were used for the shielding modification design of the Nuclear Ship "MUTSU". The calculations of the radiation distribution on board were made using Sn codes ANISN and TWOTRAN, a point kernel code QAD and a Monte Carlo code MORSE.<BR>The accuracies of these calculations were investigated through the analysis of various shielding experiments: the shield tank experiment of the Nuclear Ship "Otto Hahn", the shielding mock-up experiment for "MUTSU" performed in JRR-4, the shielding benchmark experiment using the <SUP>16</SUP>N radiation facility of AERE Harwell and the shielding effect experiment of the ship structure performed in the training ship "Shintoku-Maru". The values calculated by the ANISN agree with the data measured at "Otto Hahn" within a factor of 2 for fast neutrons and within a factor of 3 for epithermal and thermal neutrons. The &gamma;-ray dose rates calculated by the QAD agree with the measured values within 30% for the analysis of the experiment in JRR-4. The design values for "MUTSU" were determined in consequence of these experimental analyses.

著者

山路 昭

出版者

明治大学教養論集刊行会

雑誌

明治大学教養論集 (ISSN:03896005)

巻号頁・発行日

no.56, pp.1-24, 1970-03

著者

三輪 芳弘 山路 昭 中浜 肇 折田 義正 福原 吉典 鎌田 武信 石橋 道男 市川 靖二 高原 史郎 園田 孝夫

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.108, no.11, pp.1087-1092, 1988-11-25 (Released:2008-05-30)

参考文献数

15

被引用文献数

1 1

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A method of high performance liquid chromatography for the determination of unchanged furosemide and its metabolites in the plasma and urine of human subjects is reported. A reversed phase Hibar Lichrosorb RP-8 column was applied to the present method. Furosemide from samples was extracted with diethylether. Beta-glucronidate of furosemide was determined after the addition of beta-glucronidase. 4-Chloro-5-sulfamoyl-anthranilic acid (CSA) was determined by the supernatant obtained from ten minutes centrifugation of the urine with ethanol. In the plasma and urine concentrations of unchanged furosemide of healthy volunteers, there were recognized differences among individuals. In patients with chronic renal failure, urine concentration of beta-glucronidate of furosemide increased in response to impairment of creatinine clearance. CSA could be detected only in the urine of patients receiving renal transplantation under a large dose administration of furosemide (above 200mg/d during rejection). And CSA does not seem to be an artifact product by the procedures of extraction. No interference could be observed by the drugs co-administered with furosemide. The present method can be utilized for a routine drug monitoring system of furosemide. Mechanism of formation of metabolites of furosemide should be further studied.

著者

山路 昭 藤井 康子 奥田 陽子 青野 真知子 佐藤 健太郎 千葉 幹夫 平岡 栄一

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.4, no.1, pp.7-11, 1978 (Released:2011-08-11)

参考文献数

7

被引用文献数

1 1

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Photodegradation of vitamin K1 and K2 injections during preservation and in intravenous admixtures was investigated by high-pressure liquid chromatography. When exposed to fluorescent light (500 lux), 50% of commercial product (10mg) of vitamin K1 decomposed in about 15 days, compared with about 10 days for the 50% decomposition of vitamin K2 product. In the intravenous admixtures for drip infusion, the residual rate after sunlight irradiation (2, 000 lux) for 3 hours was 43-63% for K1 and 31-44% for K2. Therefore, intravenous admixtures containing theselight-unstable injections require shading during drip infusion. In Osaka University Hospital, the light-resistant covers of containers for injections are used for this purpose.

著者

山路 昭雄

出版者

運輸省船舶技術研究所

雑誌

船舶技術研究所報告 (ISSN:0495775X)

巻号頁・発行日

vol.37, no.6, 2000

著者

丸田 栄一 但馬 重俊 廣谷 芳彦 前田 義美 西井 諭司 東 敏夫 山路 昭 紀氏 汎恵 平岡 栄一 三牧 孝至 田川 哲三 藪内 百治

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.11, no.5, pp.398-402, 1985-10-20 (Released:2011-08-11)

参考文献数

15

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Phenytoin (PHT) fine granule, which has the same bioavailability as the tablet, has recently been marketed. We projected a change of PHT dosage form from usual powder to fine granule. In view of the fact that 97% of PHT products prescribed and marketed are available in fine granules, 50% PHT preparations were produced in hospital pharmacy. 5 kinds of preparations using various lactoses as diluents were prepared and tested for their quality. Among them, the preparation from Aleviatin fine granule passing through a 42-mesh sieve and EFC lactose showed the best results in the mixing property and various sense tests. The change to this dosage form and its bioavailability tests were carried out by a cooperation of doctors and pharmacists. Serum PHT levels of all patients, assayed by EMIT method, showed a 20% to 30% increase after the administration of the new preparation (50% PHT fine granule with EFC lactose).

著者

兵藤 知典 竹内 清 中田 正也 宮坂 駿一 金森 善彦 東原 義治 梅田 巌 木村 逸郎 山越 寿夫 高橋 善昭 古田 悠 内田 俊介 田中 義久 片岡 巌 播磨 良子 布施 卓嘉 中井 優 島村 光 大久保 正紀 田中 俊一 三浦 俊正 伊藤 泰義 西村 達雄 中村 尚司 金井 康二 山路 昭雄 植木 紘太郎 木邨 祐二 竹村 守雄

出版者

一般社団法人 日本原子力学会

雑誌

日本原子力学会誌 (ISSN:00047120)

巻号頁・発行日

vol.15, no.5, pp.312-321, 1973-05-30 (Released:2010-04-19)

参考文献数

74

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This is a report on the activities of the Research Committee on Neutron Shielding (Apr. 1970-Mar. 1973), Atomic Energy Society of Japan. The Committee studied the present status and problems in Japan and the trends in foreign countries in such fields as neutron reactor shielding, including transport calculations, duct streaming, spectroscopy, shielding optimization and cross sections for shielding calculations. Three working groups established in the Committee-Neutron Transport, Duct Streaming and Cross Section for Shielding-undertook such activities as (a) calculations of the five benchmark problems for testing computational methods in neutron transport, (b) a survey of theoretical and experimental approaches to duct streaming, and (c) intercomparison of nuclear data for particular nuclides related to shielding in data libraries such as ENDF/B-I, III, KFK-120 and -750.