著者

高木 省治郎 須田 啓一 小松 則夫 大田 雅嗣 加納 康彦 北川 誠一 坪山 明寛 雨宮 洋一 元吉 和夫 武藤 良知 坂本 忍 高久 史麿 三浦 恭定

出版者

The Japanese Society of Hematology

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.27, no.12, pp.2274-2280, 1986

---

Five patients with malignant lymphoma in whom primary chemotherapy had failed were treated with high-dose chemotherapy using AAABC regimen, total body irradiation, and transplantation of cryopreserved autologous marrow. Complete remission was achieved in all five patients. In these patients, the recurrence of malignant lymphoma did not occur during the follow up time of 2 to 59 months after autologous bone marrow transplantation. Three of them are alive in continuous remission for 33, 49, and 59 months, respectively. In one of these three patients, acute lymphoblastic leukemia developed 44 months after bone marrow transplantation. However, successful chemotherapy resulted in a complete remission of leukemia, he is alive in remission. The remaining two patients died of pneumonia and respiratory failure 72 days and 82 days after bone marrow transplantation, respectively. Our results show that intensive chemoradiotherapy and autologous-marrow transplantation can produce a prolonged remission in patients with malignant lymphoma in whom conventional chemotherapy has failed.