著者

高木 麻衣 相良 篤信 石澤 歩実 伊藤 文香 宮崎 雅之 千﨑 康司 永井 拓 山田 清文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.139, no.10, pp.1327-1332, 2019-10-01 (Released:2019-10-01)

参考文献数

14

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The dosage of cisplatin is adjusted according to creatinine clearance (Ccr) estimated by the Cockcroft-Gault formula, which is commonly used as a marker for renal function. It is known that different serum creatinine (Scr) levels are reported depending on the analytical methods utilized such as the Scr level by the enzyme method being lower than that by the Jaffe method. Although the enzyme method is used in Japan, most drug dosages, including cisplatin, are adjusted according to the estimated Ccr using the Jaffe method-based Scr level. The purpose of this study was to investigate whether assessment of renal function with or without Scr adjustment affects cisplatin-based chemotherapy in cervical cancer patients. The patients were divided into two groups, normal (Ccr≥60 mL/min with adjusted Scr) and false normal (Ccr<60 mL/min with adjusted Scr, but Ccr≥60 mL/min with non-adjusted Scr). The false normal group had significantly higher rates of cisplatin dose reduction after the second course than the normal group (p<0.05). Leukocytopenia and Grade 2 or higher neutropenia were significantly more common in the false normal group than in the normal group (p<0.05). These results suggest that evaluation of renal function using the adjusted Scr is important for the accurate dosage of cisplatin and that it helps to improve the patient's quality of life. Further investigations may provide useful information for accurate and safe cisplatin-based chemotherapy for cancer patients.

著者

高木 麻衣子

出版者

東京福祉大学短期大学部

雑誌

若手研究(B)

巻号頁・発行日

2017-04-01

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筋電計を用い、初心者と熟練者のピアノ奏法の「見える化」を行った。素材として、シャンドールの5つの基本動作(自由落下・スケール・回転・スタッカート・突き)を使用し、初心者30人、熟練者30人の計測を行い、一定の結果を得ることができた。研究以前の予測とは違った結果も見られ、各々の奏法における筋肉の使い方を可視化することに成功し、次の研究に繋がる成果を得ることができた。