著者

白水 俊介 岩崎 雄介 畦地 拓哉 安部 智哉 兼平 暖 相良 篤信 里 史明 湯本 哲郎 亀井 淳三

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.46, no.1, pp.1-6, 2020-01-10 (Released:2021-01-11)

参考文献数

10

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Saccharated ferric oxide is an iron preparation for intravenous injection obtained by colloidal particles of ferric hydroxide with sucrose. Although it is necessary to dilute saccharated ferric oxide with a 10-20% glucose injection solution according to the product labeling, it is often diluted with 5% glucose injection solution and/or saline in clinical practice. In the present study, we evaluated the stability of saccharated ferric oxide in various diluted solutions in terms of the abundance of free iron ions. The abundance ratio of free iron ions significantly increased with pH elevation of the diluted solution. Moreover, a marked decrease in the abundance ratio of free iron ions was observed in the sodium chloride solution exceeding the physiological concentration (0.9%). Furthermore, a statistical decrease in the abundance ratio of free iron ions was confirmed in the glucose solution compared to saline, and the degree of liberation of free iron ions in 5% glucose solution was the lowest among various concentrations of glucose solution. These results indicate the possibility that saccharated ferric oxide can be diluted by 5% glucose injection solution with minimal effects on its stability, although its dilution according to the product labeling is basically important.

著者

堀内 正子 相良 篤信 吉田 梨紗 小林 百代 竹ノ谷 文子 琉子 友男 小林 哲郎 仲間 若菜 黄 仁官 里 史明 湯本 哲郎

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.47, no.12, pp.659-666, 2021-12-10 (Released:2022-12-10)

参考文献数

15

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The number of people taking nutritional supplements has increased rapidly due to heightened health consciousness; however, cases of doping through supplement intake have also increased. Therefore, pharmacists need to share not only instructions related to medication, but also anti-doping (AD) directions for supplements with athletes. However, reports on the use of supplements in athletes are limited, and the actual situation is unknown. Then, we conducted a questionnaire survey on 1,249 physical education university students regarding the use of supplements and their awareness on doping. We also examined the steps that need to be taken by pharmacists to facilitate AD.We found that 60% of the respondents had taken supplements, 50% of whom (i.e., 30% of the total respondents) continued to do so. Furthermore, 40% took multiple supplements and were at risk of ‘inadvertent doping.’ Most of the respondents took supplements for improving muscle strength, fatigue recovery, and malnutrition. Furthermore, friends and seniors were often the triggers for supplement intake, suggesting that leaders and teams were also involved. Since many respondents purchased supplements at drug stores, it is important for pharmacists to educate athletes and their leaders about AD. Further, supplements, like pharmaceuticals, are constantly advancing and therefore pharmacists need to expand their knowledge and strive to expand their role.

著者

高木 麻衣 相良 篤信 石澤 歩実 伊藤 文香 宮崎 雅之 千﨑 康司 永井 拓 山田 清文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.139, no.10, pp.1327-1332, 2019-10-01 (Released:2019-10-01)

参考文献数

14

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The dosage of cisplatin is adjusted according to creatinine clearance (Ccr) estimated by the Cockcroft-Gault formula, which is commonly used as a marker for renal function. It is known that different serum creatinine (Scr) levels are reported depending on the analytical methods utilized such as the Scr level by the enzyme method being lower than that by the Jaffe method. Although the enzyme method is used in Japan, most drug dosages, including cisplatin, are adjusted according to the estimated Ccr using the Jaffe method-based Scr level. The purpose of this study was to investigate whether assessment of renal function with or without Scr adjustment affects cisplatin-based chemotherapy in cervical cancer patients. The patients were divided into two groups, normal (Ccr≥60 mL/min with adjusted Scr) and false normal (Ccr<60 mL/min with adjusted Scr, but Ccr≥60 mL/min with non-adjusted Scr). The false normal group had significantly higher rates of cisplatin dose reduction after the second course than the normal group (p<0.05). Leukocytopenia and Grade 2 or higher neutropenia were significantly more common in the false normal group than in the normal group (p<0.05). These results suggest that evaluation of renal function using the adjusted Scr is important for the accurate dosage of cisplatin and that it helps to improve the patient's quality of life. Further investigations may provide useful information for accurate and safe cisplatin-based chemotherapy for cancer patients.

著者

堀内 正子 相良 篤信 吉田 梨紗 小林 百代 竹ノ谷 文子 琉子 友男 小林 哲郎 仲間 若菜 黄 仁官 里 史明 湯本 哲郎

出版者

日本社会薬学会

雑誌

社会薬学 (ISSN:09110585)

巻号頁・発行日

vol.40, no.1, pp.27-35, 2021-06-10 (Released:2021-06-29)

参考文献数

19

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Introduction: Recently, doping among athletes has been on the rise, and pharmacists have an important role in both the promotion of anti-doping (AD) and in providing accurate information and effective support. In this study, we examined various fact-finding surveys that targeted physical education university (PEU) students, and we focused on their use of pharmacies/drugstores, their involvement with pharmacists, and knowledge about AD. We also examined the necessary AD-related professional competencies of pharmacists. Method: Questionnaire surveys were prepared, and the responses of 1,249 students were analyzed. Results : From a survey on what students buy at pharmacies/drug stores it showed that medicines for flu common colds sell the most. Most of the students did not receive any drug consultations at pharmacies/drug stores before purchasing, because they preferred to make their own decisions about drug use. Also, many students were wary of doping with supplements. Although the students who participated in international sports competitions and events possessed a wealth of doping-related knowledge and awareness, PEU students lacked them. Discussion : We determined that it was necessary to gather relevant patient information and explore methods so that intentions could be discussed when purchasing medications from pharmacies/drug stores. We also recognized the need for early doping education programs in light of the inadequate AD-related knowledge and awareness among university student-athletes. Therefore, all pharmacists should strive to acquire a wide range of knowledge to support athletes in this effort. Furthermore, we believe that expanding the professional functions of pharmacists would increase the awareness of AD among athletes.