著者

Hiroyuki Tsutsui Tomomi Ide Hiroshi Ito Yasuki Kihara Koichiro Kinugawa Shintaro Kinugawa Miyuki Makaya Toyoaki Murohara Koichi Node Yoshihiko Saito Yasushi Sakata Wataru Shimizu Kazuhiro Yamamoto Yasuko Bando Yu-ki Iwasaki Yoshiharu Kinugasa Isamu Mizote Hitoshi Nakagawa Shogo Oishi Akiko Okada Atsushi Tanaka Takashi Akasaka Minoru Ono Takeshi Kimura Shun Kosaka Masami Kosuge Shin-ichi Momomura on behalf of the Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0431, (Released:2021-09-29)

参考文献数

252

被引用文献数

84

著者

Kazuhiko Hara Takahiro Shinozaki Akiko Okada-Ogawa Yumiko Matsukawa Ko Dezawa Yuka Nakaya Jui-Yen Chen Noboru Noma Shunichi Oka Koichi Iwata Yoshiki Imamura

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.58, no.2, pp.195-204, 2016 (Released:2016-06-25)

参考文献数

44

被引用文献数

7 25

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We investigated the temporal association between temporomandibular disorders (TMD)-related symptoms and headache during TMD treatment for patients who fulfilled the diagnostic criteria for headache attributed to TMD (HATMD) specified in the Diagnostic criteria for TMD (DC/TMD) and International classification of headache disorders (ICHD)-3 beta. The study enrolled 34 patients with HATMD induced by masticatory myofascial pain but not by temporomandibular arthralgia. Facial pain intensity, the pressure pain threshold of pericranial muscles, and maximum unassisted opening of the jaw were assessed at an initial examination and before and after physical therapy. The intensity and frequency of headache episodes and tooth contact ratio were also recorded before and after the intervention. Headache intensity and frequency significantly decreased, and these reductions were temporally related to improvements in facial pain intensity, maximum unassisted opening, and pressure pain threshold during TMD treatment. Linear regression analysis showed significant correlations between facial pain intensity and headache intensity and between tooth contact ratio and pressure pain threshold. Among patients who fulfilled the DC/TMD and ICHD-3 beta diagnostic criteria for HATMD, headache improved during TMD treatment, and the improvement was temporally related to amelioration of TMD symptoms. These findings suggest that sensitization in the central and peripheral nervous systems is responsible for HATMD. (J Oral Sci 58, 195-204, 2016)

著者

Keita Takizawa Souichirou Tadokoro Kana Ozasa Akiko Okada-Ogawa Andrew Young Noboru Noma

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

pp.23-0155, (Released:2023-10-19)

参考文献数

10

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Abstract: Various neuropathies of the cranil nerves can accompany trigeminal neuropathic pain attributed to space-occupying lesions. In this case report, the patient presented with persistent intraoral pain and numbness on the right side of the face. Cranial nerve examination revealed dysfunctional eye movements, diplopia, and mechanical hyposensitivity in the mandibular region. The patient was diagnosed with neuropathy due to intracranial lesions and referred to the Department of Neurosurgery and Otorhinolaryngology. The patient was suspected of having malignant lymphoma and is currently undergoing neurosurgical intervention. This article discusses the importance of the examination of the cranial nerve for patients with persistent pain in the trigeminal nerve distribution.

著者

Naohiko Sekine Akiko Okada-Ogawa Sayaka Asano Daiki Takanezawa Chisa Nishihara Natsuko Tanabe Yoshiki Imamura

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.62, no.4, pp.387-392, 2020 (Released:2020-09-26)

参考文献数

92

被引用文献数

3

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The cause of burning mouth syndrome (BMS) is unknown. Although no effective treatment has been established, BMS patients frequently chew gum to alleviate pain. To identify the cause and new treatments for BMS, this study investigated the psychophysical and pharmacological properties of gum chewing to better understand its pain-relieving effects. In this prospective, blinded study, plasma catecholamine and serotonin levels and Profile of Mood States (POMS) scores were assessed after gum chewing or simulated chewing in 40 women (20 BMS patients and 20 age-matched controls). Visual analogue scale (VAS) scores for pain decreased significantly in BMS patients after gum chewing and simulated chewing. Moreover, resting VAS scores of BMS patients were significantly positively correlated with plasma adrenaline level. Furthermore, gum chewing was significantly correlated with lower plasma adrenaline level, VAS score, and tension-anxiety score. These results suggest that adrenaline is important in the pathogenesis of BMS pain and that the analgesic effect of gum chewing is induced through the potential effects of anxiety reduction, although this effect might not be specific to BMS. In addition, the analgesic effect of gum chewing was not induced solely by chewing motion.

著者

岡田 章子 Akiko Okada

雑誌

英米評論 = English Review (ISSN:09170200)

巻号頁・発行日

no.7, pp.123-138, 1993-01-29

著者

Yoshiki Imamura Akiko Okada-Ogawa Noboru Noma Takahiro Shinozaki Kosuke Watanabe Ryutaro Kohashi Masamichi Shinoda Akihiko Wada Osamu Abe Koichi Iwata

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

pp.19-0459, (Released:2020-03-11)

参考文献数

87

被引用文献数

7

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Burning mouth syndrome (BMS) is one of the most frequently seen idiopathic pain conditions in a dental setting. Peri- and postmenopausal women are most frequently affected, and patients who experience BMS complain of persistent burning pain mainly at the tip and the bilateral border of the tongue. Recent studies have assessed whether BMS is a neuropathic pain condition, based on morphologic changes in biopsied tongue specimens, and whether there are abnormal pain responses in patients with this disease. Somatosensory studies have reported some abnormal findings in sensory and pain detection thresholds with inconsistency; however, the most distinct finding was exaggerated responses to painful stimuli. Imaging and electrophysiologic studies have suggested the possibility of dysregulation of the pain-modulating system in the central nervous system, which may explain the enhanced pain responses despite the lack of typical responses toward quantitative sensory tests. Basic studies have suggested the possible involvement of neuroprotective steroids, although the underlying mechanisms of this condition have not been elucidated. Experimental studies are looking for preferable supportive therapies for BMS patients despite the obscure pathogenesis.

著者

Jui Yen Chen Asako Kubo Masamichi Shinoda Akiko Okada-Ogawa Yoshiki Imamura Koichi Iwata

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.62, no.1, pp.13-17, 2020 (Released:2020-01-29)

参考文献数

22

被引用文献数

7

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Although xerostomia can cause persistent oral pain, the mechanisms underlying such pain are not well understood. To evaluate whether a phosphorylated p38 (pp38)-TRPV4 mechanism in trigeminal ganglion (TG) neurons has a role in mechanical hyperalgesia of dry tongue, a rat model of dry tongue was used to study the nocifensive reflex and pp38 and TRPV4 expression in TG neurons. The head-withdrawal reflex threshold for mechanical stimulation of the tongue was significantly lower in dry-tongue rats than in sham rats. The numbers of TRPV4- and pp38-immunoreactive cells in the TG were significantly higher in dry-tongue rats than in sham rats. Many TRPV4-IR cells were also pp38-immunoreactive. The number of TRPV1-IR cells was unchanged in the TG after induction of tongue dryness. Local injection of a TRPV4 blocker attenuated tongue mechanical hypersensitivity in dry-tongue rats. Intraganglionic injection of a selective p38 MAP kinase inhibitor eliminated tongue hypersensitivity in dry-tongue rats and suppressed TRPV4 expression in TG neurons. The present findings suggest that TRPV4 activation via p38 phosphorylation in TG neurons is involved in mechanical hypersensitivity associated with dry tongue. These mechanisms may have a role in pain associated with xerostomia.

著者

Akiko Okada-Ogawa Naohiko Sekine Kosuke Watanabe Ryutaro Kohashi Sayaka Asano Koich Iwata Yoshiki Imamura

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

pp.17-0453, (Released:2018-12-20)

参考文献数

53

被引用文献数

8

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Assessment and treatment of masticatory myofascial pain syndrome (MPS) are not standardized and remain controversial. We examined whether muscle hardness was useful for evaluating masticatory MPS and analyzed the effectiveness of treatments such as stretching and massage (SM) and trigger point injection (TPI). Twenty healthy volunteers and 20 MPS patients were enrolled. MPS patients were divided into TPI and SM treatment groups. Hardness of masticatory muscle with a taut band (TB) and change in hardness were evaluated after SM and TPI treatments. Hardness values were significantly higher in muscle including a TB (TB point) than in the muscle of healthy controls. Visual analogue scale scores were significantly lower after SM and TPI treatments, and hardness of the TB point was significantly lower after SM but not after TPI. These results suggest that measurement of muscle hardness, including the TB, is useful for evaluating masticatory MPS. However, TPI analgesia might not be caused by change in muscle hardness. The mechanisms underlying the effects of SM and TPI on reducing pain in MPS may differ and thus warrant further research.

著者

岡田 章子 Akiko OKADA 桃山学院大学文学部

雑誌

英米評論 = ENGLISH REVIEW (ISSN:09170200)

巻号頁・発行日

no.9, pp.139-159, 1994-12-20

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Contemporary women novelists are interesting to me as my fellow travellers in the present-day society. Anita Brookner is particularly familiar and attractive because her novels deal with women who work in the universities and libraries. They seem to be my colleagues. Besides, the streets, the parks, and the shops which I saw in my recent visit to London are vividly described in her novels. These things stimulate me to imagine what England is and what British women are. Brookner's attractive appearance in her photograph also draws me into her world. Brookner's biography is not very well known. She withholds talking about herself and has stopped giving interviews because of the misunderstanding and defamation she had suffered. But in her novels, especially the first three, her life and character are living. Brookner's novels are permeated with profound loneliness. The first book, A Start in Life, is the most autobiographical. It opens with the striking sentence: "Dr. Weiss, at forty, knew that her life had been ruined by literature." Then she looks back at her unhappy life from childhood through her professional career. Meanwhile, the loneliness Ruth Weiss suffers is minutely expressed: how she hates to go home, how she sits alone at a coffee bar on the station platform, and how she stays up in the library until nine o'clock. This loneliness makes her devote herself excessively to her lover when she falls in love. She borrows a flat so that she can invite her lover to dinner at home. She prepares an elaborate dinner for him, which turns out to be meaningless, because he arrives hours late for a trivial reason. She marries her father's exmistress's nephew for convenience, but after six months he is killed in a traffic accident. This brief, loveless marriage gives her momentary security, which, Brookner says, all women need. In the end, she gets a position in a college and looks after her old father. The next novel, Providence, has autobiographical overlays and also reveals a lonely heroine. Kitty Maule is a visiting lecturer in a university. She falls in love with Maurice, her colleague. She, like Ruth, devotes herself entirely to him. Though she is an excellent teacher, her job is significant not for its own sake but for Maurice's sake. Staff meetings are great occasions to her, as she can see him there. She knows that "a man gets tired of a woman if she sacrifices everything for him," but she cannot get rid of her obsession because of loneliness. The description of the minutes waiting for her lover's message in a hotel is almost tragic. She has waited so keenly that when he appears, she is absent-minded. This love ends unfruitfully; after the lecture which she has to give to be promoted to a formal staff position, she finds that Maurice is going to marry one of her students, not very bright. Though she succeeds in getting the promotion, she is thrown into deeper solitude. The third novel, Look at Me, shows a slightly different approach. This time Francis Hinton tells her story in the first person. She works at a reference library in a medical research institute. Her daily life is lonely, especially on holidays. To herself, she names the melancholy feeling on holidays as the "Public Holiday Syndrome." To alleviate the feeling, she writes; she has already published two stories in an American journal. Francis is, in a way, a contrast to Ruth and Kitty; she has a lover named James for whom she does not have to wait. She knows when she can see him next time; she spends relaxing time with him. She does not write on these happy days. But the tragedy comes from her girlfriend whom she trusts. Her love is interfered with by the friend, and James falls in love with Maria, a flippant girl. Francis, in her unhappiness, starts to write again; the story ends with "I pick up my pen. I start writing." This is highly autobiographical, as Brookner says in an interview that she writes to remedy her neurosis. To Brookner, women cannot be happy with professional success; rather it is an outlet for frustrated feelings. She skillfully represents the solitude and the intimate thought processes of intellectual women. Generally they are old-fashioned and hardly seem to be the twentieth century's women. Brookner wants to say that women's loneliness, especially that of single women, cannot be changed, however the society changes. She does not write of men's solitude. Probably she writes only through her feelings.