著者

井上 大介 Daisuke INOUE

出版者

創価大学社会学会

雑誌

ソシオロジカ (ISSN:03859754)

巻号頁・発行日

vol.38, no.1, pp.29-55, 2014-03-20

著者

HyungChanKim Daisuke Inoue Masashi Eto JungsukSongKojiNakao

雑誌

コンピュータセキュリティシンポジウム2009 (CSS2009) 論文集

巻号頁・発行日

vol.2009, pp.1-6, 2011-10-12

---

In these days, it is very prevalent to discover many packed malwares caught inany malware collecting systems including honeypots. Thus, the initial step for usual malwareanalysis involves unpacking binary samples. In this paper, we present a yet another methodof generic binary unpacking. A typical packed binary includes stub code that takes chargeof unrolling packed data at the early stage of program execution thereby realizing originalexecution context. Our approach is basically to measure code revelation/concealment based onbyte state model that reflects the behavior of such stub code. We also describe a proof-of-conceptimplementation based on Bochs x86 system emulator.

著者

Rieko Takatani Takuo Kubota Masanori Minagawa Daisuke Inoue Seiji Fukumoto Keiichi Ozono Yosikazu Nakamura

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.33, no.11, pp.569-573, 2023-11-05 (Released:2023-11-05)

参考文献数

18

被引用文献数

2

---

Background: Pseudohypoparathyroidism (PHP) and nonsurgical hypoparathyroidism (NS-HypoPT) are rare diseases with hypocalcemia, hyperphosphatemia, and high and low parathyroid hormone levels, respectively. In Japan, over 20 years have passed since the last survey on these diseases. We carried out a nationwide cross-sectional survey to estimate the prevalence of these diseases in 2018.Methods: We conducted a nationwide mail-based survey targeting hospitals in 2018. From a total of 13,156 departments throughout Japan, including internal medicine, pediatrics, neurology, and psychiatry, 3,501 (27%) departments were selected using a stratified random sampling method. We asked each included department to report the number of patients with PHP and NS-HypoPT in 2017.Results: The overall survey response rate was 52.0% (1,807 departments). The estimated number of patients with PHP and NS-HypoPT was 1,484 (95% confidence interval [CI], 1,143–1,825) and 2,304 (95% CI, 1,189–3,419), respectively; the prevalence per 100,000 population was 1.2 and 1.8, respectively.Conclusion: In this study, we generated estimates of the national prevalence of PHP and NS-HypoPT in Japan during 2017, which were found to be higher than those previously reported.

著者

Ryo Okazaki Keiichi Ozono Seiji Fukumoto Daisuke Inoue Mika Yamauchi Masanori Minagawa Toshimi Michigami Yasuhiro Takeuchi Toshio Matsumoto Toshitsugu Sugimoto

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ16-0548, (Released:2016-12-20)

被引用文献数

36

---

Vitamin D is indispensable for the maintenance of bone and mineral health. Inadequate vitamin D action increases the risk for various musculoskeletal/mineral events including fracture, fall, secondary hyperparathyroidism, diminished response to antiresorptives, rickets/osteomalacia, and hypocalcemia. Its most common cause in recent years is vitamin D deficiency/insufficiency, clinically defined by low serum 25-hydroxyvitamin D [25(OH)D] level. Guidelines for vitamin D insufficiency/deficiency defined by serum 25(OH)D concentrations have been published all over the world. In Japan, however, the information on the associations between serum 25(OH)D and bone and mineral disorders has not been widely shared among healthcare providers, partly because its measurement had not been reimbursed with national medical insurance policy until August 2016. We have set out to collect and analyze Japanese data on the relationship between serum 25(OH)D concentration and bone and mineral events. Integrating these domestic data and published guidelines worldwide, here we present the following assessment criteria for vitamin D sufficiency/insufficiency/deficiency using serum 25(OH)D level in Japan. 1) Serum 25(OH)D level equal to or above 30 ng/ml is considered to be vitamin D sufficient. 2) Serum 25(OH)D level less than 30 ng/ml but not less than 20 ng/ml is considered to be vitamin D insufficient. 3) Serum 25(OH)D level less than 20 ng/ml is considered to be vitamin D deficient. We believe that these criteria will be clinically helpful in the assessment of serum 25(OH)D concentrations and further expect that they will form a basis for the future development of guidelines for the management of vitamin D deficiency/insufficiency.

著者

Yuichiro Tsurusaki Shota Sakai Takao Morita Kenji Miki Daisuke Inoue Sei Haga Shoji Arihiro

出版者

The Japanese Society for Neuroendovascular Therapy

雑誌

Journal of Neuroendovascular Therapy (ISSN:18824072)

巻号頁・発行日

pp.cr.2022-0049, (Released:2022-08-20)

参考文献数

9

---

Objective: We report a case of huge scrotal hematoma during emergency mechanical thrombectomy.Case Presentation: An 85-year-old man presented with sudden aphasia and right-sided hemiplegia. He was diagnosed with cerebral infarction due to left M1 occlusion and underwent an emergency mechanical thrombectomy. The treatment was completed with full recanalization, but when replacing the long sheath in the right femoral artery with a short sheath, the patient flexed his leg. The sheath could not be replaced, resulting in a massive scrotal hematoma. Shortly after, the patient went into cardiopulmonary arrest but recovered spontaneous circulation after cardiopulmonary resuscitation. The puncture site was treated hemostatically with manual compression, and the scrotal hematoma was not enlarged. He was transferred to another hospital with a modified Rankin Scale score of 5.Conclusion: Scrotal hematoma is a rare but potentially fatal puncture site complication that should be considered during neuro-endovascular treatment.

著者

井上 大介 Daisuke INOUE

出版者

創価大学社会学会

雑誌

ソシオロジカ (ISSN:03859754)

巻号頁・発行日

vol.38, no.1・2, pp.29-55, 2014-03-20

著者

Ryo Okazaki Keiichi Ozono Seiji Fukumoto Daisuke Inoue Mika Yamauchi Masanori Minagawa Toshimi Michigami Yasuhiro Takeuchi Toshio Matsumoto Toshitsugu Sugimoto

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.64, no.1, pp.1-6, 2017 (Released:2017-01-30)

参考文献数

31

被引用文献数

12 36

---

Vitamin D is indispensable for the maintenance of bone and mineral health. Inadequate vitamin D action increases the risk for various musculoskeletal/mineral events including fracture, fall, secondary hyperparathyroidism, diminished response to antiresorptives, rickets/osteomalacia, and hypocalcemia. Its most common cause in recent years is vitamin D deficiency/insufficiency, clinically defined by low serum 25-hydroxyvitamin D [25(OH)D] level. Guidelines for vitamin D insufficiency/deficiency defined by serum 25(OH)D concentrations have been published all over the world. In Japan, however, the information on the associations between serum 25(OH)D and bone and mineral disorders has not been widely shared among healthcare providers, partly because its measurement had not been reimbursed with national medical insurance policy until August 2016. We have set out to collect and analyze Japanese data on the relationship between serum 25(OH)D concentration and bone and mineral events. Integrating these domestic data and published guidelines worldwide, here we present the following assessment criteria for vitamin D sufficiency/insufficiency/deficiency using serum 25(OH)D level in Japan. 1) Serum 25(OH)D level equal to or above 30 ng/mL is considered to be vitamin D sufficient. 2) Serum 25(OH)D level less than 30 ng/mL but not less than 20 ng/mL is considered to be vitamin D insufficient. 3) Serum 25(OH)D level less than 20 ng/mL is considered to be vitamin D deficient. We believe that these criteria will be clinically helpful in the assessment of serum 25(OH)D concentrations and further expect that they will form a basis for the future development of guidelines for the management of vitamin D deficiency/insufficiency.

著者

Rajani Ghaju Shrestha Yasuhiro Tanaka Bikash Malla Sarmila Tandukar Dinesh Bhandari Daisuke Inoue Kazunari Sei Jeevan B. Sherchand Eiji Haramoto

出版者

Japanese Society of Microbial Ecology · The Japanese Society of Soil Microbiology

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

pp.ME18052, (Released:2018-09-06)

被引用文献数

12

---

Arcobacter spp. are emerging pathogens associated with gastroenteritis in humans. The objective of this study was to develop a highly sensitive and broadly reactive quantitative PCR (qPCR) assay for Arcobacter spp. and to apply the developed assay to different water sources in the Kathmandu Valley, Nepal. Fifteen samples to be analyzed by next-generation sequencing were collected from 13 shallow dug wells, a deep tube well, and a river in the Kathmandu Valley in August 2015. Among the 86 potential pathogenic bacterial genera identified, Acinetobacter, Pseudomonas, Flavobacterium, and Arcobacter were detected with relatively high abundance in 15, 14, 12, and 8 samples, respectively. A primer pair was designed with maximal nucleotide homologies among Arcobacter spp. by comparing the sequences of 16S rRNA genes. These primers were highly specific to most of the known species of Arcobacter and quantified between 1.0×101 and 6.4×106 copies reaction–1 and sometimes detected as few as 3 copies reaction–1. The qPCR assay was used to quantify Arcobacter spp. in bacterial DNA in not only the above 15 water samples, but also in 33 other samples collected from 15 shallow dug wells, 6 shallow tube wells, 5 stone spouts, 4 deep tube wells, and 3 springs. Thirteen (27%) out of 48 samples tested were positive for Arcobacter spp., with concentrations of 5.3–9.1 log copies 100 mL–1. This qPCR assay represents a powerful new tool to assess the prevalence of Arcobacter spp. in environmental water samples.

著者

Takahiro KASAMA Katsunari YOSHIOKA Daisuke INOUE Tsutomu MATSUMOTO

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Fundamentals of Electronics, Communications and Computer Sciences (ISSN:09168508)

巻号頁・発行日

vol.E96-A, no.1, pp.225-232, 2013-01-01

---

As the number of new malware has increased explosively, traditional malware detection approaches based on pattern matching have been less effective. Therefore, it is important to develop a detection method which relies on not signatures but characteristic behaviors of malware. Recently, malware authors have been embedding functions for countermeasure against malware analyses and detections into malware. Accordingly, modern malware often changes their runtime behaviors in each execution to tolerate against malware analyses and detections. For example, when malware copies itself on a file system, it can randomly determine its file name for avoiding the detections. Another example is that when malware tries to connect its command and control server, it randomly chooses a domain name from a hard-coded domain name list to avoid being blocked by a static blacklist of malicious domain names. We assume that such evasive behaviors are unnecessary for benign software. Therefore the behaviors can be the clues to distinguish malware from benign software. In this paper, we propose a novel behavior-based malware detection method which focuses attention on such characteristics. Our proposed method conducts dynamic analysis on an executable file multiple times in same sandbox environment so as to obtain plural lists of API call sequences and plural traffic logs, and then compares the lists and the logs to find the difference between the multiple executions. In the experiments with 5,697 malware samples and 819 benign software samples, we can detect about 70% malware samples and the false positive rate is about 1%. In addition, we can detect about 50% malware samples which were not detected by each Anti-Virus Software engine. Therefore we confirm the possibility the proposed method may be able to improve the accuracy of malware detection utilizing in combination with other existing methods.