著者
Takayuki Ishihara Isamu Mizote Daisuke Nakamura Naotaka Okamoto Tatsuya Shiraki Naoki Itaya Takuya Tsujimura Mitsuyoshi Takahara Takaharu Nakayoshi Osamu Iida Yosuke Hata Masami Nishino Takafumi Ueno Daisaku Nakatani Shungo Hikoso Shinsuke Nanto Toshiaki Mano Yasushi Sakata The COLLABORATION Investigators
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-22-0098, (Released:2022-06-04)
参考文献数
31
被引用文献数
4

Background: A polymer-free biolimus A9-coated stent (PF-BCS) may achieve better arterial healing than a durable polymer drug-eluting stent owing to its polymer-free feature.Methods and Results: This multicenter, prospective, observational study enrolled 105 patients (132 lesions) who underwent PF-BCS (51 patients, 71 lesions) or durable polymer everolimus-eluting stent (DP-EES, 54 patients, 61 lesions) implantation. Serial coronary angioscopy (CAS) and optical coherence tomography (OCT) examinations were performed at 1 and 12 months, and the serial vessel responses were compared between PF-BCS and DP-EES. The primary outcome measure was the incidence of subclinical intrastent thrombus on CAS. The secondary outcome measures were: adequate strut coverage (≥40 μm) on OCT and maximum yellow color grade on CAS. The incidence of thrombus was high at 1 month (100% vs. 93%, P=0.091), but decreased at 12 months (18% vs. 25%, P=0.56), without a significant difference between PF-BCS and DP-EES. The adequate strut coverage rate was significantly higher (84±14% vs. 69±22%, P<0.001) and yellow color was significantly less intense (P=0.012) at 12 months in PF-BCS than in DP-EES; however, they were not significantly different at 1 month (adequate strut coverage: 47±21% vs. 50±17%, P=0.40; yellow color: P=0.99).Conclusions: Although the thrombogenicity of PF-BCS was similar to that of DP-EES, the adequate coverage and plaque stabilization rates of PF-BCS were superior to those of DP-EES at 12 months.
著者
中村 大介 Daisuke Nakamura
雑誌
関西学院哲学研究年報 (ISSN:02892928)
巻号頁・発行日
vol.41, pp.41-59, 2008-03-10
著者
Yu ITAMI Daisuke NAKAMURA Atsushi YASUMOTO Takao HIRAJIMA Martin SVOJTKA
出版者
Japan Association of Mineralogical Sciences
雑誌
Journal of Mineralogical and Petrological Sciences (ISSN:13456296)
巻号頁・発行日
vol.117, no.1, pp.220221, 2022 (Released:2022-10-28)
参考文献数
52
被引用文献数
1

The origins of eclogite associated with garnet peridotite in continent–continent collision belts are still debated. We performed petrological studies of eclogites collected from a garnet peridotite block from Nové Dvory in the Gföhl Unit of the Moldanubian Zone in the Variscan orogenic belt, Czech Republic. The eclogite was divided into three types: one kyanite (Ky)–bearing and two Ky–free types. Garnet and omphacite in the Ky–bearing eclogite have lower Fe contents than those in the Ky–free eclogite. Furthermore, the Ky–free eclogite was divided into two types on the basis of Ca content in garnet: Ca–rich (Xgrs > 0.32) and Ca–poor (Xgrs < 0.32) types, except for Ca–poor rim compositions. Application of conventional geothermobarometers to the Ky–bearing type and the Ky–free type with Ca–rich garnet yielded similar pressure–temperature (P–T) conditions (3.2–4.8 GPa and 920–1160 °C) to those of previous studies, whereas the Ky–free type with Ca–poor garnet yielded slightly lower P–T conditions (3.1–3.4 GPa and 950–990 °C) than the other two types. The observed chemical variation of garnet is probably due to the difference in origins, whereby, according to our new results and previous findings, the Ky–bearing eclogite was derived from plagioclase–bearing crustal gabbro, whereas the Ky–free eclogite with Ca–rich garnet was derived from a crystal cumulate possibly in the mantle wedge. In the Ky–free eclogite samples with Ca–poor garnet, chemical compositions of garnet and omphacite are different from those in the other Ky–free samples, and those samples with Ca–poor garnet would have a different origin from the others. One of the Ky–free type with Ca–poor garnet retains garnet grains with chemical zonings probably created during the prograde history, although the eclogite underwent the extremely high temperature (~ 1000 °C) metamorphism. Calculated diffusion distances in garnet reach 0.5 mm during 2 million years, even if we adopted a low value of diffusion coefficient data. Thus, the residence time of the eclogite at the peak meatamorphic conditions would have been shorter than at least 2 million years. The subsequent decompression and cooling after the peak metamorphism were also probably very fast to avoid the chemical homogenization of garnet.
著者
Daisuke Nakamura Keisuke Yasumura Hitoshi Nakamura Yutaka Matsuhiro Koji Yasumoto Akihiro Tanaka Yasuharu Matsunaga-Lee Masamichi Yano Masaki Yamato Yasuyuki Egami Ryu Shutta Yasushi Sakata Jun Tanouchi Masami Nishino
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.83, no.2, pp.313-319, 2019-01-25 (Released:2019-01-25)
参考文献数
24
被引用文献数
2 19

Background: There are few reports about the differences between drug-eluting stents (DES) and bare metal stents (BMS) in neoatherosclerosis associated with in-stent restenosis (ISR), so we compared the frequency and characteristics of neoatherosclerosis with ISR evaluated by optical coherence tomography (OCT) in the present study. Methods and Results: Between March 2009 and November 2016, 98 consecutive patients with ISR who underwent diagnostic OCT were enrolled: 34 patients had a BMS, 34 had a 1st-generation DES, and 30 had a 2nd-generation DES. Neoatherosclerosis was defined as a lipid neointima (including a thin-cap fibroatheroma [TCFA] neointima, defined as a fibroatheroma with a fibrous cap <65 µm) or calcified neointima. As a result, lipid neointima, TCFA neointima and calcified neointima were detected in 39.8%, 14.3%, and 5.1%, respectively, of all patients. The frequency of neoatherosclerosis was significantly greater with DES than BMS (48.4% vs. 23.5%, P=0.018). The minimum fibrous cap thickness was significantly thicker with DES than BMS (110.3±41.1 µm vs. 62.5±17.1 µm, P<0.001). In addition, longitudinal extension of neoatherosclerosis in the stented segment was less with DES than BMS (20.2±15.1% vs. 71.8±27.1%, respectively, P=0.001). Conclusions: OCT imaging demonstrated that neoatherosclerosis with ISR was more frequent with DES than BMS and its pattern exhibited a more focal and thick fibrous cap as compared with BMS.