著者

Mari Matsumoto Manabu Sakaguchi Shuhei Okazaki Kazuo Hashikawa Tsutomu Takahashi Masayasu Matsumoto Toshiho Ohtsuki Takeshi Shimazu Toshiki Yoshimine Hideki Mochizuki Kazuo Kitagawa

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-0707, (Released:2017-01-31)

参考文献数

18

被引用文献数

1 7

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Background:In Japan, warfarin treatment at prothrombin time-international normalized ratio (PT-INR) of 1.60–2.60 is recommended for elderly patients with nonvalvular atrial fibrillation (NVAF). But it remains unknown whether PT-INR 1.60–1.99 has a similar effect on stroke severity as a value >2.0. The purpose of this study was to clarify the association between infarct volume and PT-INR levels.Methods and Results:The 180 patients (mean age, 76 years [SD, 10 years], 53% male) selected from 429 consecutive ischemic stroke patients admitted within 48 h of onset between 2004 and 2014 with NVAF were included. We classified them into 4 groups according to their PT-INR values on admission: no warfarin (NW), 129 patients; PT-INR <1.60 (poor control: PC), 29 patients; PT-INR 1.60–1.99 (low-intensity control: LC), 14 patients; and PT-INR ≥2.00 (high-intensity control: HC), 8 patients. Median (interquartile range: IQR) of infarct volume was 55 mL (IQR 14–175) in the NW, 42 mL (IQR 27–170) in the PC, 36 mL (IQR 6–130) in the LC, and 11 mL (IQR 0–39) in the HC groups. The infarct volume of the HC group was significantly smaller than in the other 3 groups, but no difference existed between the LC and PC groups or the LC and NW groups.Conclusions:Warfarin control at PT-INR of 1.60–1.99 is not effective for reducing the severity of ischemic stroke in NVAF patients.

著者

Takemasa ISHIKAWA Fumiya SANO Yugo NARITA Seiichi NAGANO Hideki MOCHIZUKI Hisatomo KOWA Kaoru KONISHI

出版者

Japan Society of Kansei Engineering

雑誌

International Symposium on Affective Science and Engineering (ISSN:24335428)

巻号頁・発行日

pp.1-4, 2023 (Released:2023-05-31)

参考文献数

11

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The transparent communication board (TCB) is a communication tool that is commonly employed by individuals with amyotrophic lateral sclerosis (ALS). Both the 50-letters and flick type TCB are prevalent in Japan. The purpose of this case study was to compare and investigate the speed of letter transmission and the subjective user impression associated with the use of the 50-letters and flick type TCB in ALS patients. The study included four ALS patients and four caregivers, who acted as communication partners. Participants used the 50-letters and flick type TCB at intervals ranging from one week to 90 days. They received video instructions on how to use each type of TCB and tried to transmit a total of 18 Japanese letters. We measured the time taken to transmit each word and the number of errors. Additionally, the participants were asked to complete a questionnaire assessing their subjective impressions of the TCB. Compared with the 50-letters type, the ALS patients and their partners tended to make fewer errors and preferred the flick type of TCB. However, the 50-letters type was easier to use to communicate if the patient and partner were not familiar with the flick type sequence. Our data suggest that the age of the patient and their partner, as well as the amount of experience using a smartphone, should be considered when choosing a TCB.

著者

Goichi Beck Rika Yamashita Chizu Saeki Takuya Ogawa Mikito Shimizu Hideki Mochizuki

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.4601-20, (Released:2020-05-26)

参考文献数

23

被引用文献数

1

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We herein report a 56-year-old Japanese woman who had been diagnosed with hereditary angioedema. She experienced progressing muscle weakness and pain in the upper and lower extremities. Blood tests revealed a marked increase in creatine kinase levels; however, myositis-specific autoantibodies were not detected. Serum C1-inhibitor activity and C4 levels were low. A muscle biopsy showed mild muscle fiber necrosis and C5b-9 deposition in the endomysial capillary vessel walls and sarcolemma, mimicking necrotizing myopathy. These results suggest that C1-inhibitor deficiency induces myositis-like symptoms through the activation of the complement pathway and deposition of the membrane attack complex in the muscles.