- 著者
- Hidenori Kato Hiroki Watanabe Akira Koike Longmei Wu Kosuke Hayashi Hirotomo Konno Takeshi Machino Isao Nishi Akira Sato Hiroaki Kawamoto Kazutaka Aonuma Yoshiyuki Sankai Masaki Ieda
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- vol.86, no.1, pp.60-67, 2021-12-24 (Released:2021-12-24)
- 参考文献数
- 29
- 被引用文献数
- 1 5
Background:Aiming to establish an effective tool in new cardiac rehabilitation programs, we investigated the use of a lumbar-type hybrid assistive limb (HAL) in patients with heart failure (HF) who had difficulty in walking at the usual speed of healthy subjects (≈80 m/min).Methods and Results:We randomly assigned 28 HF patients (age, 73.1±13.8 years) to perform a sit-to-stand exercise with or without HAL. The sit-to-stand exercise was repeated as many times as possible as cardiac rehabilitation therapy over a period of 6–10 days. We measured 5 parameters before and after the completion of cardiac rehabilitation: B-type natriuretic peptide, Short Physical Performance Battery (SPPB), 6-min walking distance (6MWD), 30-s chair-stand test (CS-30), and isometric knee extensor muscle strength. The SPPB and 6MWD were significantly improved, and the CS-30 score was somewhat improved, after the exercise therapy in both the HAL and non-HAL groups. The knee extensor muscle strength improved significantly in the HAL group (0.29±0.11 to 0.35±0.11 kgf/kg, P<0.01), but showed no change in the non-HAL group (0.35±0.11 to 0.35±0.13 kgf/kg, P=0.40).Conclusions:The improved knee extensor muscle strength in the HAL group suggests that the lumbar-type HAL may be an effective tool for cardiac rehabilitation in HF patients with frailty, which is a predictor of poor prognosis in HF.
- 著者
- Hidenori Kato Hiroki Watanabe Akira Koike Longmei Wu Kosuke Hayashi Hirotomo Konno Takeshi Machino Isao Nishi Akira Sato Hiroaki Kawamoto Kazutaka Aonuma Yoshiyuki Sankai Masaki Ieda
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-21-0381, (Released:2021-09-11)
- 参考文献数
- 29
- 被引用文献数
- 5
Background:Aiming to establish an effective tool in new cardiac rehabilitation programs, we investigated the use of a lumbar-type hybrid assistive limb (HAL) in patients with heart failure (HF) who had difficulty in walking at the usual speed of healthy subjects (≈80 m/min).Methods and Results:We randomly assigned 28 HF patients (age, 73.1±13.8 years) to perform a sit-to-stand exercise with or without HAL. The sit-to-stand exercise was repeated as many times as possible as cardiac rehabilitation therapy over a period of 6–10 days. We measured 5 parameters before and after the completion of cardiac rehabilitation: B-type natriuretic peptide, Short Physical Performance Battery (SPPB), 6-min walking distance (6MWD), 30-s chair-stand test (CS-30), and isometric knee extensor muscle strength. The SPPB and 6MWD were significantly improved, and the CS-30 score was somewhat improved, after the exercise therapy in both the HAL and non-HAL groups. The knee extensor muscle strength improved significantly in the HAL group (0.29±0.11 to 0.35±0.11 kgf/kg, P<0.01), but showed no change in the non-HAL group (0.35±0.11 to 0.35±0.13 kgf/kg, P=0.40).Conclusions:The improved knee extensor muscle strength in the HAL group suggests that the lumbar-type HAL may be an effective tool for cardiac rehabilitation in HF patients with frailty, which is a predictor of poor prognosis in HF.
- 著者
- Sogo Nishio Shingo Terakami Toshimi Matsumoto Toshiya Yamamoto Norio Takada Hidenori Kato Yuichi Katayose Toshihiro Saito
- 出版者
- 一般社団法人 園芸学会
- 雑誌
- The Horticulture Journal (ISSN:21890102)
- 巻号頁・発行日
- pp.OKD-093, (Released:2017-07-21)
- 被引用文献数
- 16
The chestnut (genus Castanea) has a long juvenile phase, and breeders have to wait three years or more to evaluate nut traits. Therefore, molecular markers associated with genes of interest are required to speed the selection process in chestnut breeding programs. Genetic linkage maps of the Japanese chestnut were constructed using two breeding populations derived from crosses between ‘Kunimi’ and breeding line ‘709-034’ (Kx709), and between ‘Porotan’ and ‘Tsukuba-43’ (Px43). Maps of the four parents and two integrated maps (one representing each cross) were constructed using 443 simple sequence repeat markers (SSRs) and 554 single-nucleotide polymorphism markers. In the Kx709 integrated map, which was the most saturated of the six maps, 12 linkage groups were identified that covered 668.1 cM with an average distance of 0.8 cM between loci. Using anchor SSRs, these six maps were successfully aligned to the Chinese chestnut consensus map. We evaluated eight important traits, including several nut traits, to identify molecular markers associated with these traits. At least one significant quantitative trait locus (QTL) was detected for each of the eight traits (21 in total). Logarithm of odds (LOD) values and phenotypic variance explained by these QTLs ranged from 2.60 to 7.90 and from 11.6% to 29.1%, respectively. In the Kx709 population analysis, several QTLs for nut harvesting date (HARVEST) and pericarp splitting (SPLIT) were detected. Under the assumption that the effects of these QTLs are additive, the percentage of total phenotypic variance explained by the combination of QTLs was high for both HARVEST (47.5%–60.8%) and SPLIT (33.4%–41.7%). Because these mapping populations and their parents are essential materials for Japanese chestnut breeding programs, these QTLs will soon be used for marker-assisted selection to improve breeding efficiency.