- 著者
- 
             
             Gen Inoue
             
             Takashi Kaito
             
             Yukihiro Matsuyama
             
             Toshihiko Yamashita
             
             Mamoru Kawakami
             
             Kazuhisa Takahashi
             
             Munehito Yoshida
             
             Shiro Imagama
             
             Seiji Ohtori
             
             Toshihiko Taguchi
             
             Hirotaka Haro
             
             Hiroshi Taneichi
             
             Masashi Yamazaki
             
             Kotaro Nishida
             
             Hiroshi Yamada
             
             Daijiro Kabata
             
             Ayumi Shintani
             
             Motoki Iwasaki
             
             Manabu Ito
             
             Naohisa Miyakoshi
             
             Hideki Murakami
             
             Kazuo Yonenobu
             
             Tomoyuki Takura
             
             Joji Mochida
             
          
- 出版者
- The Japanese Society for Spine Surgery and Related Research
- 雑誌
- Spine Surgery and Related Research (ISSN:2432261X)
- 巻号頁・発行日
- pp.2020-0083,  (Released:2020-11-20)
- 被引用文献数
- 
             
             
             2
             
             
          
        
        Introduction: Chronic low back pain (CLBP) is a leading cause of disability, yet there is limited high-quality evidence to identify the most suitable pharmacological therapy. The purpose of this Japanese nationwide, multicenter, prospective study was to compare the effectiveness of four representative drug therapies—acetaminophen, celecoxib, loxoprofen, and a tramadol and acetaminophen (T+A) combination drug—to establish evidence for a drug of choice for CLBP.Methods: Patients with CLBP (N = 471) received one of the four treatments and were evaluated, prospectively and comprehensively, once every month for six months using a visual analog scale (VAS) for LBP, the Japanese Orthopedic Association (JOA) score, the JOA Back Pain Evaluation Questionnaire (JOABPEQ), the Roland–Morris Disability Questionnaire (RDQ), the EuroQol five-dimensions three-levels (EQ-5D-3L), and the Short Form-8 item health survey (SF-8). We conducted multivariable linear regression analyses of the four drugs at 1 and 6 months after drug allocation. Differences with P < 0.05 were considered statistically significant.Results: Patients who received acetaminophen showed a significant improvement from baseline in the mental health subscale of the JOABPEQ at one month (P = 0.02) and the JOA score at six months (P < 0.01). None of the other outcome measures among the four drugs differed significantly. Across groups, all outcome measures, except the mental component summary (MCS) score of the SF-8, improved equivalently, although most measurements showed no obvious cumulative effect over six months. The MCS score of the SF-8 decreased gradually over six months in all groups.Conclusions: Most of the outcome measures among the treated groups were not significantly different, indicating similar treatment effects of the four drugs for CLBP. Our study indicated the limit of each outcome measure for evaluating the patient status, suggesting that a single outcome measure is insufficient to reflect treatment effectiveness.