著者

Ayumu Fujioka Kenji Yanishi Arito Yukawa Kojiro Imai Isao Yokota Kei Fujikawa Ayumu Yamada Akari Naito Keisuke Shoji Hirofumi Kawamata Yukihito Higashi Tomoaki Ishigami Ken-ichiro Sasaki Syuhei Tara Koichiro Kuwahara Satoshi Teramukai Satoaki Matoba

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0046, (Released:2023-03-10)

参考文献数

24

被引用文献数

4

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Background: Thromboangiitis obliterans (TAO) can lead to the development of critical limb-threatening ischemia (CLTI). Despite conventional treatments, such as smoking cessation or revascularization, young patients (<50 years) still require limb amputation. Therapeutic angiogenesis using bone marrow-derived mononuclear cell (BM-MNC) implantation has been tested and shown to have reasonable efficacy in CLTI. In this multicenter prospective clinical trial, we evaluated the safety and efficacy of BM-MNC implantation in CLTI patients with TAO.Methods and Results: We enrolled 22 CLTI patients with skin perfusion pressure (SPP) <30 mmHg. The primary endpoint of this trial is the recovery of SPP in the treated limb after a 180-day follow-up period. Secondary endpoints include the pain scale score and transcutaneous oxygen pressure (TcPO2). One patient dropped out during follow-up, leaving 21 patients (mean age 48 years, 90.5% male, Fontaine Class IV) for analysis. BM-MNC implantation caused no serious adverse events and increased SPP by 1.5-fold compared with baseline. Surprisingly, this effect was sustained over the longer term at 180 days. Secondary endpoints also supported the efficacy of this novel therapy in relieving pain and increasing TcPO2. Major amputation-free and overall survival probabilities at 3 years among all enrolled patients were high (95.5% and 89.5%, respectively).Conclusions: BM-MNC implantation showed safety and significant efficacy in CLTI patients with TAO.

著者

Satoshi Kobayashi Toshiya Osanai Taku Sugiyama Noriyuki Fujima Ryo Takagi Isao Yokota Akiyoshi Hamaguchi Toshitaka Nakamura Kazutoshi Hida Miki Fujimura

出版者

The Japanese Society for Neuroendovascular Therapy

雑誌

Journal of Neuroendovascular Therapy (ISSN:18824072)

巻号頁・発行日

pp.oa.2023-0001, (Released:2023-05-17)

参考文献数

20

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Objective: In endovascular treatment, it is important to evaluate the access route for placing a catheter into the common carotid artery (CCA) promptly and safely prior to the procedure. We examined whether non-contrast MRA using time-spatial labeling inversion pulse (Time-SLIP) can be used in patients prior to endovascular thrombectomy for acute ischemic stroke. We compared Time-SLIP MRA to contrast-enhanced (CE) MRA and evaluated the efficacy in the evaluation of access routes.Methods: We retrospectively reviewed 31 patients admitted between October 2018 and December 2018 for cerebral infarction at our hospital. Blood vessels were imaged from the aortic arch to the CCA. A radiologist blindly evaluated quality score, stenosis, shape of the aorta, and degree of tortuosity.Results: There were no “non-diagnostic” images. The sensitivity, specificity, positive predictive value, and negative predictive value for stenosis were 83%, 96%, 83%, and 96%, respectively. The sensitivity for the aorta type classification was 100%. The sensitivity for mild tortuosity was 93%, for moderate was 100%, and for severe was 100%.Conclusion: Time-SLIP MRA can be an alternative to CE MRA in access route assessment for patients with cerebral infarction who are not eligible for acute thrombectomy therapy.

著者

Emi Ushigome Chikako Oyabu Keiko Iwai Nobuko Kitagawa Aya Kitae Tomonori Kimura Isao Yokota Hidetaka Ushigome Masahide Hamaguchi Mai Asano Masahiro Yamazaki Michiaki Fukui

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.65, no.3, pp.252-257, 2019 (Released:2019-11-01)

参考文献数

24

被引用文献数

6

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The aim of the present study was to examine whether dietary salt restriction guidance is beneficial for dietary salt restriction and lowering of home blood pressure in patients with diabetes with excessive salt intake. We performed an intervention trial of 37 people with type 2 diabetes and excessive salt intake. National registered dietitians provided dietary salt restriction guidance to each patient at the start of the study. All participants were instructed to perform triplicate morning and evening home blood pressure measurements using home blood pressure telemonitoring system. Daily salt intake at 2 months and 6 months was significantly lower than that at baseline; the difference was 0.8 [95% confidence interval (CI): 0.2–1.4, p = 0.009] g and 0.7 (95% CI: 0.1–1.3, p = 0.009) g, respectively. Morning systolic blood pressure at 2 months and 6 months was significantly lower than that at baseline; the difference was 2.7 (95% CI: 0.2–5.1, p = 0.034) mmHg and 5.8 (95% CI: 0.5–11.1, p = 0.034) mmHg, respectively. This intervention study revealed, for the first time, that dietary salt restriction guidance provided by a national registered dietitian is beneficial for reducing daily salt intake and home blood pressure in people with diabetes with excessive salt intake.

著者

Yuto Tashiro Yuichi Nishida Ayaka Yamaoka Yusuke Suzuki Takayoshi Horii Hiroaki Arai Yutaka Yamaguchi Naoya Wada Isao Yokota Tomoki Aoyama

出版者

Japanese Association of Occupational Therapists

雑誌

Asian Journal of Occupational Therapy (ISSN:13473476)

巻号頁・発行日

vol.16, no.1, pp.87-93, 2020 (Released:2020-12-15)

参考文献数

31

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Objectives: There are only a few functional evaluations that non-medical personnel can perform and interpret without guidance. Here, we have created a questionnaire that focused on eating activities, which can be used to evaluate motor function easily because most people could relate to eating activities. This study aimed to verify the reliability and validity of the developed questionnaire by comparing it with clinical evaluations for upper extremity function.Methods: This was a cross-sectional study. Patients who have cerebrovascular disease history with disabilities in the upper limb were included in the study. The questionnaire on eating activities was answered by the patients themselves. Upper extremity function was evaluated with the Fugl-Meyer Assessment (FMA). Work efficiency was evaluated with the General Aptitude Test Battery. Reliability of the questionnaire was assessed by test-retest reliability. Validity was evaluated using a correlation analysis.Results: The study included 16 participants. The results indicated that all items had sufficient reliability. The correlation between the questionnaire score of the hand and the FMA score of the wrist, hand, and arm was statistically significant.Conclusions: The developed questionnaire was reliable and significantly related to clinical evaluation of upper extremity functions. This questionnaire is of great value to patients with stroke to understand their functions.