- 著者
-
Kitano Motoo
Hirano Masao
Ishihara Takashi
YOSHIDA Aichi
HATTORI Shosaku
UEDA Naoko
CHIJIWA Takahito
OHNO Motonori
キタノ モトオ
ヒラノ マサト
イシハラ タカシ
ヨシダ アイチ
ハットリ ショウサク
ウエダ ナオコ
チヂワ タカヒト
オオノ モトノリ
北野 元生
平野 真人
石原 尚
吉田 愛知
服部 正策
上田 直子
千々岩 崇仁
大野 素徳
- 出版者
- 鹿児島大学
- 雑誌
- 南太平洋研究 (ISSN:09160752)
- 巻号頁・発行日
- vol.23, no.1, pp.11-18, 2002
Trimeresurus flavoviridis (Tf) serum proteins were fractionated by anmnonium sulfate precipitation to five portions depending on the differences of its saturation percentages, that is, 0-20%, 20-30%, 30-40%, 40-50%, and 50-70%. The effects of these proteins on Tf venom-induced rat skeletal muscle damage were investigated with closer attention to histopathological features of impairment, necrosis, and regeneration ofmuscle fibers. The knowledges which portion of Tf serum proteins is effective for prevention of local lesions caused by Tf venom should shed light on the effective medical treatment after bitten by Tf snake. In consequence, it was found that the necrotic change of the rats inoculated with Tf crude venom together with the serum protein fraction of ammonium sulfate saturation percentage 40-50% was the smallest compared to those of the rats tested with other Tf serum protein fractions.