著者
兼松 顯 内藤 良 下東 康幸 大野 素徳 小笠原 富夫 黒野 昌庸 八木 國夫
出版者
公益社団法人日本薬学会
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.38, no.5, pp.1438-1440, 1990-05-25 (Released:2008-03-31)
参考文献数
6
被引用文献数
7 14

An S-activated sulfhydrylmorphine derivative was synthesized, and its linking to the μ-opioid receptor through a disulfide bond was demonstrated.
著者
Kitano Motoo Hirano Masao Ishihara Takashi YOSHIDA Aichi HATTORI Shosaku UEDA Naoko CHIJIWA Takahito OHNO Motonori キタノ モトオ ヒラノ マサト イシハラ タカシ ヨシダ アイチ ハットリ ショウサク ウエダ ナオコ チヂワ タカヒト オオノ モトノリ 北野 元生 平野 真人 石原 尚 吉田 愛知 服部 正策 上田 直子 千々岩 崇仁 大野 素徳
出版者
鹿児島大学
雑誌
南太平洋研究 (ISSN:09160752)
巻号頁・発行日
vol.23, no.1, pp.11-18, 2002

Trimeresurus flavoviridis (Tf) serum proteins were fractionated by anmnonium sulfate precipitation to five portions depending on the differences of its saturation percentages, that is, 0-20%, 20-30%, 30-40%, 40-50%, and 50-70%. The effects of these proteins on Tf venom-induced rat skeletal muscle damage were investigated with closer attention to histopathological features of impairment, necrosis, and regeneration ofmuscle fibers. The knowledges which portion of Tf serum proteins is effective for prevention of local lesions caused by Tf venom should shed light on the effective medical treatment after bitten by Tf snake. In consequence, it was found that the necrotic change of the rats inoculated with Tf crude venom together with the serum protein fraction of ammonium sulfate saturation percentage 40-50% was the smallest compared to those of the rats tested with other Tf serum protein fractions.