BNT162b2 (Pfizer/BioNTech) is a coronavirus disease 2019 (COVID-19) vaccine containing nucleoside-modified messenger RNA encoding the severe acute respiratory syndrome coronavirus 2 spike glycoprotein. Recently, ocular complications of mRNA vaccines have been reported increasingly frequently. However, immunological adverse events due to mRNA vaccines in real-world settings are not fully known. We herein report the novel development of sarcoidosis manifested as uveitis, bilateral hilar lymphadenopathy, angiotensin-converting enzyme elevation, and epithelioid and giant cell granuloma formation in the lung soon after the first BNT162b2 injection and review the current literature, including three reported cases of sarcoid-like reaction following COVID-19 vaccination.
An 85-year-old man underwent emergency right trepanation and drainage for a symptomatic chronic subdural hematoma. Pseudohypoxic brain swelling (PHBS) was suspected because magnetic resonance imaging revealed diffuse brain swelling. Although cerebrospinal fluid (CSF) leakage was not obvious during or after surgery, most of the reported PHBS cases have leaked CSF during craniotomy or spine surgery. PHBS has not been previously reported in patients without obvious CSF leakage or after unilateral burr hole drainage. Herein, we report an extremely rare case with a literature review investigating its pathogenesis and clinical features.
本研究では、地域づくりの優良事例の内容をミクロに分析し「住民主導」の内実を明らかにすることを目的とした。本事例からは、地区住民から出された要望を地域リーダーが具体化し、それを自治会役員会が承認し、地区全体の活動として実施するという、活動における地域リーダー層の役割を明らかにすることができた。こうした地域リーダー層以外の一般住民の意識と活動に対する関与の実態を明らかにすることを目的としたアンケート調査を行った。その結果、地区住民の中には「地域づくりを支持はするが、自ら積極的にかかわりたいとまでは思わない」といういわば「消極的支持層」が存在することが明らかになった。In J area in Murone village, Iwate Prefecture, several community activities have been found to contribute to revitalization of the rural community and people's exchange with visitors. This study is to analyze the involvement of local people in the development process of those activities, to discuss how the activities became possible and to analyze the consciousness of local people about those activities. The result of the questionnaire are summarized as follows : 1) a half or more local people agreed to do those activities, 2) though some of them had intention of leaving up those activities to someone else.