著者

Toshihiro TAKAMI Takeshi HARA Masahito HARA Toshihiko INUI Kiyoshi ITO Izumi KOYANAGI Junichi MIZUNO Masaki MIZUNO Hiroyuki NAKASE Nobuyuki SHIMOKAWA Taku SUGAWARA Shinsuke SUZUKI Toshiyuki TAKAHASHI Masakazu TAKAYASU Satoshi TANI Kazutoshi HIDA Phyo KIM Hajime ARAI Neurospinal Society of Japan The Japan Neurosurgical Society

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.2022-0148, (Released:2022-10-13)

参考文献数

74

被引用文献数

1

---

Anterior cervical disc replacement (ACDR) using cervical artificial disc (CAD) has the advantage of maintaining the range of motion (ROM) at the surgical level, subsequently reducing the postoperative risk of adjacent disc disease. Following the approval for the clinical use in Japan, a post-marketing surveillance (PMS) study was conducted for two different types of CAD, namely, Mobi-C (metal-on-plastic design) and Prestige LP (metal-on-metal design). The objective of this prospective observational multicenter study was to analyze the first 2-year surgical results of the PMS study of 1-level ACDR in Japan. A total of 54 patients were registered (Mobi-C, n = 24, MC group; Prestige LP, n = 30, PLP group). Preoperative neurological assessment revealed radiculopathy in 31 patients (57.4%) and myelopathy in 15 patients (27.8%). Preoperative radiological assessment classified the disease category as disc herniation in 15 patients (27.8%), osteophyte in 6 patients (11.1%), and both in 33 patients (61.1%). The postoperative follow-up rates at 6 weeks, 6 months, 1 year, and 2 years after ACDR were 92.6%, 87.0%, 83.3%, and 79.6%, respectively. In both groups, patients' neurological condition improved significantly after surgery. Radiographic assessment revealed loss of mobility at the surgical level in 9.5% of patients in the MC group and in 9.1% of patients in the PLP group. No secondary surgeries at the initial surgical level and no serious adverse events were observed in either group. The present results suggest that 1-level ACDR is safe, although medium- to long-term follow-up is mandatory to further verify the validity of ACDR for Japanese patients.

著者

Masaki Mizuno Jere H. Mitchell Scott A. Smith

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.5, no.5, pp.339-347, 2016-11-25 (Released:2016-11-10)

参考文献数

120

被引用文献数

4

---

The cardiovascular response to physical exercise is abnormally exaggerated in hypertension. Since such responses potentially increase the risk for adverse cardiovascular events, it is clinically important to elucidate the cause of this cardiovascular hyper-excitability in this disease. Even if blood pressure is normal at rest, individuals displaying a heightened blood pressure response to exercise are more likely to develop future hypertension. Therefore, early detection of this abnormal circulatory response to physical activity could lead to the early treatment as well as prevention of hypertension. Much evidence suggests that the abnormal exercise pressor reflex (EPR; a reflex originating in exercising skeletal muscle) significantly contributes to the generation of the enhanced circulatory responses in this disease. In addition, it has been demonstrated that the EPR dysfunction is mediated by both mechanically-sensitive fibers associated with the muscle mechanoreflex and chemically-sensitive fibers associated with the muscle metaboreflex. This review focuses on the underlying mechanisms for this overactive EPR function in hypertension. Specifically, updates on our current understanding of the EPR in this disease as well as experimental models used to examine this reflex are presented.

著者

Keita Kuraishi Masaki Mizuno Kazuhiro Furukawa Hidenori Suzuki

出版者

一般社団法人 日本脳神経外科学会

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.3, no.2, pp.45-47, 2016 (Released:2016-04-01)

参考文献数

13

被引用文献数

1

---

A 49-year-old man with cervical spondylosis at the C2–4 level presented with onion-skin hemifacial dysesthesia in addition to the right extremities. C2–4 anterior cervical decompression and fusion were performed. Onion-skin hemifacial pain disappeared after surgery. Although we cannot conclude the etiology of the pain was either referred pain or direct injury to the spinal trigeminal nucleus, cervical spondylosis at the middle cervical level has a possibility to present facial pain.