- 著者
- 
             
             Miwa Yamaguchi
             
             Kokichi Arisawa
             
             Hirokazu Uemura
             
             Sakurako Katsuura-Kamano
             
             Hidenobu Takami
             
             Fusakazu Sawachika
             
             Mariko Nakamoto
             
             Tomoya Juta
             
             Eisaku Toda
             
             Kei Mori
             
             Manabu Hasegawa
             
             Masaharu Tanto
             
             Masayuki Shima
             
             Yoshio Sumiyoshi
             
             Kenji Morinaga
             
             Kazunori Kodama
             
             Takaichiro Suzuki
             
             Masaki Nagai
             
             Hiroshi Satoh
             
          
- 出版者
- (公社)日本産業衛生学会
- 雑誌
- Journal of Occupational Health (ISSN:13419145)
- 巻号頁・発行日
- pp.12-0264-OA,  (Released:2013-04-09)
- 被引用文献数
- 
             
             11
             
             
             54
             
             
          
        
        Objective: Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) have been shown to accumulate in the human body. The purpose of the present study was to examine the factors associated with the blood levels of PFOS and PFOA. Methods: A cross-sectional study was performed on 307 men and 301 women (aged 16-76 years) living in 15 prefectures in Japan. Blood levels of PFOS and PFOA were measured by liquid chromatography-mass spectrometry. Hepatic enzymes (γ-GTP, GOT, and GPT) and ω-3 polyunsaturated fatty acids (DHA and EPA) levels in serum were also measured. Associations between the levels of PFOS and PFOA in blood and the intake frequency of 41 kinds of dishes, foods and beverages and the serum levels of liver enzymes and ω-3 polyunsaturated fatty acids were examined using rank correlations. Results: Frequency of intake of boiled fish in broth, sliced raw fish and coastal fish showed significant positive correlations with PFOS concentrations in blood after adjustments for potential confounders. Serum levels of GOT, GPT, DHA and EPA showed significant positive correlations with PFOS and PFOA in blood. There was also a significant regional difference in the blood levels of PFOS and PFOA, with medians being highest in the Tokai/Hokuriku/Kinki region. Conclusion: These findings suggest that the concentrations of PFOS in blood were mainly associated with fish consumption and that the levels of PFOS and PFOA were mainly associated with the serum levels of liver enzymes in Japanese populations. Further investigations are required to clarify the reason for the regional differences in blood levels of PFOS and PFOA in Japan.